N-(indazol-5-yl)-5-chloroanthranilic acid amide | 267891-87-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(indazol-5-yl)-5-chloroanthranilic acid amide
• 英文别名: 2-amino-5-chloro-N-(1H-indazol-5-yl)benzamide
• CAS: 267891-87-2
• 化学式: C₁₄H₁₁ClN₄O
• 分子量: 286.721
• InChiKey: MZLPGAONSQAIPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.8
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(indazol-5-yl)-5-chloroanthranilic acid amide 在 盐酸 、 sodium nitrite 作用下， 反应 1.0h， 以64%的产率得到6-Chloro-3-(1H-indazol-5-yl)-3H-benzo[d][1,2,3]triazin-4-one
  参考文献：
  名称：

  Synthesis and antifungal activity of new N-(1-phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides

  摘要：

  N-(1-Phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides 6, with a Benodanil-like structure, were synthesized by refluxing in acetic acid the corresponding benzotriazin ones 5 with potassium iodide for 1 h in order to study the role on the antifungal activity of the N-substitution with an aromatic heterocyclic system on benzamide moiety. Among the tested iododerivatives, compounds 6d,f,g,h possess interesting activities toward some phytopathogenic fungal strains. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

  DOI：

  10.1016/s0014-827x(01)01190-9
• 作为产物：
  描述：

  5-氯-2-硝基苯甲酸 在 盐酸 、 氯化亚砜 、 tin(ll) chloride 作用下， 反应 31.0h， 生成 N-(indazol-5-yl)-5-chloroanthranilic acid amide
  参考文献：
  名称：

  Synthesis and antifungal activity of new N-(1-phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides

  摘要：

  N-(1-Phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides 6, with a Benodanil-like structure, were synthesized by refluxing in acetic acid the corresponding benzotriazin ones 5 with potassium iodide for 1 h in order to study the role on the antifungal activity of the N-substitution with an aromatic heterocyclic system on benzamide moiety. Among the tested iododerivatives, compounds 6d,f,g,h possess interesting activities toward some phytopathogenic fungal strains. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

  DOI：

  10.1016/s0014-827x(01)01190-9

文献信息

• Anthranilic acid amides and the use thereof as medicaments
  申请人：Schering AG

  公开号：US07122547B1

  公开（公告）日：2006-10-17

  The invention relates to anthranilic acid amides and the use thereof as medicaments for the treatment of diseases that are triggered by persistent angiogenesis, in addition to intermediate products in the production of anthranilic acid amides.

  本发明涉及到蒽酰胺及其作为治疗由持续血管生成引起的疾病的药物，以及在蒽酰胺的生产中的中间体产品。
• ANTHRANILSÄUREAMIDE UND DEREN VERWENDUNG ALS ARZNEIMITTEL
  申请人：SCHERING AKTIENGESELLSCHAFT

  公开号：EP1129074A2

  公开（公告）日：2001-09-05
• US7122547B1
  申请人：——

  公开号：US7122547B1

  公开（公告）日：2006-10-17
• [DE] ANTHRANILSÄUREAMIDE UND DEREN VERWENDUNG ALS ARZNEIMITTEL<br/>[EN] ANTRHRANILIC ACID AMIDES AND THE USE THEREOF AS MEDICAMENTS<br/>[FR] AMIDES D'ACIDE ANTHRANILIQUE ET LEUR UTILISATION COMME MEDICAMENT
  申请人：SCHERING AG

  公开号：WO2000027819A2

  公开（公告）日：2000-05-18

  Es werden Anthranilsäureamide und deren Verwendung als Arzneimittel zur Behandlung von Erkrankungen, die durch persistente Angiogenese ausgelöst werden, sowie deren Zwischenprodukte zur Herstellung der Anthranilsäureamide beschrieben.
• Synthesis and antifungal activity of new N-(1-phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides
  作者：Demetrio Raffa、Giuseppe Daidone、Fabiana Plescia、Domenico Schillaci、Benedetta Maggio、Livio Torta

  DOI：10.1016/s0014-827x(01)01190-9

  日期：2002.3

  N-(1-Phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides 6, with a Benodanil-like structure, were synthesized by refluxing in acetic acid the corresponding benzotriazin ones 5 with potassium iodide for 1 h in order to study the role on the antifungal activity of the N-substitution with an aromatic heterocyclic system on benzamide moiety. Among the tested iododerivatives, compounds 6d,f,g,h possess interesting activities toward some phytopathogenic fungal strains. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.