4-iodo-N-(2-hydroxyethyl)benzamide | 57728-65-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-iodo-N-(2-hydroxyethyl)benzamide
• 英文别名: N-(2-hydroxyethyl)-4-iodobenzamide
• CAS: 57728-65-1
• 化学式: C₉H₁₀INO₂
• mdl: MFCD02218108
• 分子量: 291.088
• InChiKey: TYKLJPGLNHBPSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-iodo-N-(2-hydroxyethyl)benzamide 在 4-二甲氨基吡啶 、 sodium hydroxide 、 正丁基锂 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 二氯甲烷 为溶剂， 反应 17.0h， 生成
  参考文献：
  名称：

  Electrostatically Controlled Hierarchical Arrangement of Monocationic Silver(I) and Dicationic Mercury(II) Ions between Disk-Shaped Template Ligands

  摘要：

  This paper describes hierarchical arrangement of three Ag+ and three Hg2+ ions using two disk-shaped hexa-monodentate template ligands in which three oxazolyl rings are arranged each on the two concentric circles. The hierarchical manner of ligand arrangement allows the selective binding of monocationic Ag+ and dicationic Hg2+ ions to the inner first and the outer second generation coordination sites, respectively. This hierarchically well-balanced metal assembly should arise primarily from a minimized electrostatic repulsion between positively charged six metal ions arranged within the heteronuclear complex.

  DOI：

  10.1021/ja064194f
• 作为产物：
  描述：

  C.I.酸性橙108 、 4-碘苯甲酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 4-iodo-N-(2-hydroxyethyl)benzamide
  参考文献：
  名称：

  [3+2]级联闭环/开环策略：获得N-茚系氨基醇

  摘要：

  完成了前所未有的原子经济氧化还原中性区域选择性 Rh(III) 催化的 2-芳基恶唑啉与 α,β-不饱和硝基烯烃的级联 [3+2] 环化，提供了一组新型硝基官能化茚束缚氨基通过协同闭环/开环策略，在无银温和反应条件下，在广泛的底物范围内形成两个新的 C-C 键，并选择性裂解恶唑啉的 C2-O 键。

  DOI：

  10.1021/acs.orglett.3c02975

文献信息

• Modular Approach to Heterogenous Catalysis. Manipulation of Cross-Coupling Catalyst Activity
  作者：Iva Stibingerova、Svatava Voltrova、Sarka Kocova、Matthew Lindale、Jiri Srogl

  DOI：10.1021/acs.orglett.5b03480

  日期：2016.1.15

  A new type of robust, heterogeneous, modular Pd catalyst with metal embedded in the gel matrix is presented. The regulatory element of its catalytic activity has been introduced via chemical changes in the gel. The concept is illustrated in a series of Suzuki-Miyaura cross-coupling reactions. The demonstrated catalyst activity variations depend on the structure of the gel.
• Electrostatically Controlled Hierarchical Arrangement of Monocationic Silver(I) and Dicationic Mercury(II) Ions between Disk-Shaped Template Ligands
  作者：Shuichi Hiraoka、Takaaki Tanaka、Mitsuhiko Shionoya

  DOI：10.1021/ja064194f

  日期：2006.10.1

  This paper describes hierarchical arrangement of three Ag+ and three Hg2+ ions using two disk-shaped hexa-monodentate template ligands in which three oxazolyl rings are arranged each on the two concentric circles. The hierarchical manner of ligand arrangement allows the selective binding of monocationic Ag+ and dicationic Hg2+ ions to the inner first and the outer second generation coordination sites, respectively. This hierarchically well-balanced metal assembly should arise primarily from a minimized electrostatic repulsion between positively charged six metal ions arranged within the heteronuclear complex.