N-tert-butoxycarbonyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)-2-phenylethylamine | 896729-39-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-tert-butoxycarbonyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)-2-phenylethylamine
• 英文别名: tert-butyl N-[1-(3-methyl-1,2,4-oxadiazol-5-yl)-2-phenylethyl]carbamate
• CAS: 896729-39-8
• 化学式: C₁₆H₂₁N₃O₃
• 分子量: 303.361
• InChiKey: FDLATISINNVXRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  77.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-tert-butoxycarbonyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)-2-phenylethylamine 、 盐酸 在 乙酸乙酯 、 1-(3-methyl-[1,2,4]oxadiazol-5-yl)-2-phenylethylamine hydrochloride 作用下， 以 乙酸乙酯 为溶剂， 反应 5.0h， 以to give 2.05 g of (R) 1-(3-methyl-[1,2,4]oxadiazol-5-yl)-2-phenylethylamine hydrochloride的产率得到1-(3-methyl-[1,2,4]oxadiazol-5-yl)-2-phenylethylamine hydrochloride
  参考文献：
  名称：

  Compounds with growth hormone releasing properties

  摘要：

  本发明公开了一种新型合成肽，其化学式为(I) ##STR1## 其中A、B、D、E、F、G、J、m、n和p在说明书中有定义。化合物(I)促进人类和动物体内生长激素的释放。本发明还公开了包含化合物(I)作为活性成分的促进生长的组合物，刺激生长激素释放的方法以及利用化合物(I)的用途。

  公开号：

  US06013658A1
• 作为产物：
  描述：

  N-叔丁氧羰基-L-苯丙氨酸甲酯 、 N-hydroxyacetamidine 在 potassium carbonate 作用下， 以 甲苯 为溶剂， 反应 6.0h， 以72%的产率得到N-tert-butoxycarbonyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)-2-phenylethylamine
  参考文献：
  名称：

  用碳酸钾一锅法从羧酸酯和a胺肟一锅合成1,2,4-恶二唑

  摘要：

  描述了一种方便的一锅合成1,2,4-恶二唑。在碳酸钾存在下，羧酸酯和and胺肟的缩合反应以中等至极好的收率合成了各种单，双和三恶二唑。

  DOI：

  10.1016/j.tetlet.2006.03.155

文献信息

• Amide compounds and use of the same
  申请人：Japan Tobacco Inc.

  公开号：US06174887B1

  公开（公告）日：2001-01-16

  An amide compound of the formula (I): wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3 and R4 are H, hydroxy and the like, R5 is H, alkyl and the like, m is an integer of 0-6, R6 is an optionally substituted aryl and the like, and R7 is H, an optionally substituted alkyl and the like, a pharmaceutically acceptable acid addition salt thereof and a pharmaceutical containing same as an active ingredient. The amide compounds exhibit superior suppressive effects on cytokines directly or indirectly involved in inflammations, such as IL-8, IL-1, IL-6, TNF-&agr;, GM-CSF and the like, and are useful for the prophylaxis and treatment of rheumatic diseases, arthritis due to gout and the like.

  化合物的结构式（I）如下： 其中R为氨基等，A为烷基等，X为O、S等，M为芳基等，R1、R2、R3和R4为H、羟基等，R5为H、烷基等，m为0-6的整数，R6为可选择取代的芳基等，R7为H、可选择取代的烷基等，其药学上可接受的酸盐和含有其作为活性成分的药物。这些酰胺化合物对直接或间接参与炎症的细胞因子，如IL-8、IL-1、IL-6、TNF-α、GM-CSF等，表现出优越的抑制作用，并可用于预防和治疗风湿病、痛风性关节炎等。
• Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases
  申请人：——

  公开号：US20020119972A1

  公开（公告）日：2002-08-29

  Use of a compound for treating a respiratory disease in a mammal wherein the compound is a cannabinoid receptor modulator is disclosed. Compounds useful as cannabinoid receptor modulators for treating respiratory and non-respiratory leukocyte-activation associated diseases comprise compounds of formula (I), 1 in which A and B are nitrogen or carbon, provided only one of A and B is nitrogen; and R 1 -R 6 are as defined in the specification, wherein R 2 with R 5 may form a ring, and/or two R 4 groups may form a six-membered aryl or heteroaryl ring, optionally having a substituent R 6 forming a ring with R 3 .

  公开了一种用于治疗哺乳动物呼吸道疾病的化合物，其中该化合物是大麻素受体调节剂。用作治疗呼吸道和非呼吸道白细胞活化相关疾病的大麻素受体调节剂的化合物包括式(I)的化合物，其中A和B是氮或碳，只要A和B中的一个是氮；R1-R6如规范中定义，其中R2和R5可以形成一个环，和/或两个R4基团可以形成一个六元芳基或杂环芳基环，可能有一个取代基R6和R3形成一个环。
• Compounds with growth hormone releasing properties
  申请人：Novo Nordisk A/S

  公开号：US06013658A1

  公开（公告）日：2000-01-11

  There are disclosed novel synthetic peptides of formula (I) ##STR1## where A, B, D, E, F, G, J, m, n, and p are defined in the specification. Compounds of formula (I) promote the release of growth hormone in humans and animals. Growth promoting compositions containing such compounds of formula (I) as the active ingredient, methods of stimulating the release of growth hormone, and the use of such compounds of formula (I) are also disclosed.

  本发明公开了一种新型合成肽，其化学式为(I) ##STR1## 其中A、B、D、E、F、G、J、m、n和p在说明书中有定义。化合物(I)促进人类和动物体内生长激素的释放。本发明还公开了包含化合物(I)作为活性成分的促进生长的组合物，刺激生长激素释放的方法以及利用化合物(I)的用途。
• Amide compounds and use thereof
  申请人：Japan Tobacco Inc.

  公开号：US06420561B1

  公开（公告）日：2002-07-16

  An amide compound of the formula (I): wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3 and R4 are H, hydroxy and the like, R5 is H, alkyl and the like, m is an integer of 0-6, R6 is an optionally substituted aryl and the like, and R7 is H, an optionally substituted alkyl and the like, a pharmaceutically acceptable acid addition salt thereof and a pharmaceutical containing same as an active ingredient. The amide compounds exhibit superior suppressive effects on cytokines directly or indirectly involved in inflammations, such as IL-8, IL-1, IL-6, TNF-&agr;, GM-CSF and the like, and are useful for the prophylaxis and treatment of rheumatic diseases, arthritis due to gout and the like.

  式(I)的酰胺化合物：其中R为氨基或类似物，A为亚烷基或类似物，X为O、S或类似物，M为芳烃基或类似物，R1、R2、R3和R4为H、羟基或类似物，R5为H、烷基或类似物，m为0-6的整数，R6为可选取代的芳基或类似物，R7为H、可选取代的烷基或类似物，其药学上可接受的酸盐和含有其作为活性成分的药物。这些酰胺化合物表现出优越的抑制作用，直接或间接地涉及炎症的细胞因子，如IL-8、IL-1、IL-6、TNF-α、GM-CSF等，可用于预防和治疗风湿性疾病、痛风性关节炎等。
• Carboxylic acid compound and use thereof
  申请人：Japan Tobacco Inc.

  公开号：EP1304322A2

  公开（公告）日：2003-04-23

  A carboxylic acid compound of the formula (I-a) wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3 and R4 are H, hydroxy and the like. The carboxylic acid compound of the formula (I-a) can be used for making an amide compound of the formula (I): wherein R, A, X, R1, R2, R3 and R4 are as described above and R5 is H, alkyl and the like, m is an integer of 0-6, R6 is an optionally substituted aryl and the like, and R7 is H, an optionally substituted alkyl and the like, a pharmaceutically acceptable acid addition salt thereof and a pharmaceutical containing same as an active ingredient. The amide compounds exhibit superior suppressive effects on cytokines directly or indirectly involved in inflammations, such as IL-8, IL-1, IL-6, TNF-α, GM-CSF and the like, and are useful for the prophylaxis and treatment of rheumatic diseases, arthritis due to gout and the like.

  式（I-a）的羧酸化合物 其中 R 是氨基等，A 是亚烷基等，X 是 O、S 等，M 是芳基等，R1、R2、R3 和 R4 是 H、羟基等。 式（I-a）的羧酸化合物可用于制造式（I）的酰胺化合物： 其中 R、A、X、R1、R2、R3 和 R4 如上所述，R5 为 H、烷基等，m 为 0-6 的整数，R6 为任选取代的芳基等，R7 为 H、任选取代的烷基等。这些酰胺化合物对直接或间接参与炎症的细胞因子，如 IL-8、IL-1、IL-6、TNF-α、GM-CSF 等具有卓越的抑制作用，可用于预防和治疗风湿性疾病、痛风引起的关节炎等。