N,N'-bis(3-aminopropyl)-N,N'-dicyclohexylhexane-1,6-diamine | 850481-16-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-bis(3-aminopropyl)-N,N'-dicyclohexylhexane-1,6-diamine
• CAS: 850481-16-2
• 化学式: C₂₄H₅₀N₄
• 分子量: 394.688
• InChiKey: JLMFTYWECVXOEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-甲基苯酐 、 N,N'-bis(3-aminopropyl)-N,N'-dicyclohexylhexane-1,6-diamine 以 甲苯 为溶剂， 反应 2.0h， 以68%的产率得到2-[3-[cyclohexyl[6-[cyclohexyl[3-(5-methyl-1,3-dioxo-1,3-dihydroisoindol-2-yl)propyl]amino]hexyl]amino]propyl]-5-methylisoindole-1,3-dione
  参考文献：
  名称：

  Allosteric Modulators of the Tertiary Alkanebisamino-Type. Variation of the Substitution of the Middle Chain Nitrogens

  摘要：

  Synthesis pathways of high flexibility for variously substituted alkanebisamine-type allosteric modulators of musearinic receptors capable of passing the blood-brain barrier were developed starting either from N,N'-(hexane-1,6-diyl)bistosylamide or adipic acid chloride. Pharmacological evaluation of some representative compounds revealed the allosteric potency to fall in a submicromolar range.

  DOI：

  10.1007/s00706-004-0218-2
• 作为产物：
  描述：

  3-[[6-[(2-cyanoethyl)cyclohexylamino]hexyl]cyclohexylamino]propionitrile 在 diborane(6) 、 盐酸 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 以84%的产率得到N,N'-bis(3-aminopropyl)-N,N'-dicyclohexylhexane-1,6-diamine
  参考文献：
  名称：

  Allosteric Modulators of the Tertiary Alkanebisamino-Type. Variation of the Substitution of the Middle Chain Nitrogens

  摘要：

  Synthesis pathways of high flexibility for variously substituted alkanebisamine-type allosteric modulators of musearinic receptors capable of passing the blood-brain barrier were developed starting either from N,N'-(hexane-1,6-diyl)bistosylamide or adipic acid chloride. Pharmacological evaluation of some representative compounds revealed the allosteric potency to fall in a submicromolar range.

  DOI：

  10.1007/s00706-004-0218-2

文献信息

• A photosensitive resin composition
  申请人：Toyo Boseki Kabushiki Kaisha

  公开号：EP0470636A1

  公开（公告）日：1992-02-12

  A photosensitive resin composition which is excellent in flexibility and impact resilience, which is less affected by humidity is provided. This composition comprises a soluble synthetic polymer, a photopolymerizable unsaturated compound, and a photo-polymerization initiator, wherein the soluble synthetic polymer comprises an addition polymer obtained by the reaction between a diamine compound having amino groups selected from primary and secondary amino groups and having no amide bonds in its molecule and a diisocyanate compound; and the addition polymer contains a polyoxyalkylene glycol component in an amount of 20 to 80% by weight.

  本发明提供了一种柔韧性和抗冲击性极佳且受湿度影响较小的光敏树脂组合物。这种组合物由可溶性合成聚合物、可光聚合的不饱和化合物和光聚合引发剂组成，其中可溶性合成聚合物包括由具有选自伯氨基和仲氨基的氨基且分子中没有酰胺键的二胺化合物与二异氰酸酯化合物反应得到的加成聚合物；加成聚合物中含有聚氧亚烷基二醇成分，其含量为 20% 至 80%（按重量计）。
• US4220704A
  申请人：——

  公开号：US4220704A

  公开（公告）日：1980-09-02
• US5204223A
  申请人：——

  公开号：US5204223A

  公开（公告）日：1993-04-20
• Allosteric Modulators of the Tertiary Alkanebisamino-Type. Variation of the Substitution of the Middle Chain Nitrogens
  作者：Rainer Pick、Seraina Duda-Johner、Christian Tr�nkle、Klaus Mohr、Ulrike Holzgrabe

  DOI：10.1007/s00706-004-0218-2

  日期：2004.12

  Synthesis pathways of high flexibility for variously substituted alkanebisamine-type allosteric modulators of musearinic receptors capable of passing the blood-brain barrier were developed starting either from N,N'-(hexane-1,6-diyl)bistosylamide or adipic acid chloride. Pharmacological evaluation of some representative compounds revealed the allosteric potency to fall in a submicromolar range.