2-Bromo-3-(hydroxymethyl)benzoic acid | 1187238-18-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Bromo-3-(hydroxymethyl)benzoic acid
• CAS: 1187238-18-1
• 化学式: C₈H₇BrO₃
• 分子量: 231.046
• InChiKey: CQNHMBLWYPOGGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Bromo-3-(hydroxymethyl)benzoic acid 在 氯化亚砜 作用下， 以 苯 为溶剂， 生成 2-bromo-3-(chloromethyl)benzoic acid
  参考文献：
  名称：

  Design, synthesis and identification of novel colchicine-derived immunosuppressant

  摘要：

  Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.054
• 作为产物：
  描述：

  2-溴-3-(溴甲基)苯甲酸甲酯 在 水 作用下， 以 甲醇 为溶剂， 生成 2-bromo-3-(bromomethyl)benzoic acid 、 2-Bromo-3-(hydroxymethyl)benzoic acid
  参考文献：
  名称：

  Design, synthesis and identification of novel colchicine-derived immunosuppressant

  摘要：

  Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.054

文献信息

• Optimized liquid-phase oxidation
  申请人：Wonders George Alan

  公开号：US20060047145A1

  公开（公告）日：2006-03-02

  Disclosed is an optimized process and apparatus for more efficiently and economically carrying out the liquid-phase oxidation of an oxidizable compound. Such liquid-phase oxidation is carried out in a bubble column reactor that provides for a highly efficient reaction at relatively low temperatures. When the oxidized compound is para-xylene and the product from the oxidation reaction is crude terephthalic acid (CTA), such CTA product can be purified and separated by more economical techniques than could be employed if the CTA were formed by a conventional high-temperature oxidation process.

  公开了一种优化的工艺和装置，用于更有效和经济地进行可氧化化合物的液相氧化。这种液相氧化是在气泡柱反应器中进行的，可以在相对较低的温度下提供高效的反应。当被氧化的化合物是对二甲苯，氧化反应的产物是粗对苯二甲酸（CTA）时，这种CTA产物可以通过比传统高温氧化工艺更经济的技术进行纯化和分离。
• Esterification of an exchange solvent enriched composition
  申请人：Parker Randolph Kenny

  公开号：US20060264664A1

  公开（公告）日：2006-11-23

  A process is provided for producing an enriched carboxylic acid compositions produced by contacting composition comprising a carboxylic acid with an enrichment feed in an enrichment zone to form an enriched carboxylic acid composition. This invention also relates to a process and the resulting compositions for removing catalyst from a carboxylic acid composition to produce a post catalyst removal composition.

  提供一种生产富集羧酸组分的方法，包括将含有羧酸的组分与富集进料在富集区接触，以形成富集羧酸组分。本发明还涉及一种方法和由此产生的组分，用于从羧酸组分中去除催化剂，以生产催化剂去除后的组分。
• Enriched terephthalic acid composition
  申请人：Gibson Edward Philip

  公开号：US20060264666A1

  公开（公告）日：2006-11-23

  A process is provided for producing an enriched carboxylic acid compositions produced by contacting composition comprising a carboxylic acid with an enrichment feed in an enrichment zone to form an enriched carboxylic acid composition. This invention also relates to a process and the resulting compositions for removing catalyst from a carboxylic acid composition to produce a post catalyst removal composition.

  本发明提供了一种生产富集羧酸组分的方法，该方法通过将含有羧酸的组分与富集进料在富集区接触，形成富集羧酸组分。本发明还涉及一种从羧酸组分中去除催化剂以生产后催化剂去除组分的方法和产生的组分。
• Esterification of an enriched composition
  申请人：Gibson Edward Philip

  公开号：US20060264662A1

  公开（公告）日：2006-11-23

  A process is provided for producing an enriched carboxylic acid compositions produced by contacting composition comprising a carboxylic acid with an enrichment feed in an enrichment zone to form an enriched carboxylic acid composition. This invention also relates to a process and the resulting compositions for removing catalyst from a carboxylic acid composition to produce a post catalyst removal composition.

  提供一种生产富集羧酸组分的方法，该方法通过将含有羧酸的组分与富集进料在富集区接触，形成富集羧酸组分。本发明还涉及一种从羧酸组分中去除催化剂以产生催化剂后去除组分的过程和得到的组分。
• Process to produce an enrichment feed
  申请人：Gibson Edward Philip

  公开号：US20060264661A1

  公开（公告）日：2006-11-23

  A process is provided for producing an enriched carboxylic acid compositions produced by contacting composition comprising a carboxylic acid with an enrichment feed in an enrichment zone to form an enriched carboxylic acid composition. This invention also relates to a process and the resulting compositions for removing catalyst from a carboxylic acid composition to produce a post catalyst removal composition.

  提供了一种生产富集羧酸组分的方法，该方法通过将含有羧酸的组分与富集进料在富集区接触，形成富集羧酸组分。本发明还涉及一种去除催化剂从羧酸组分中生产后催化剂去除组分的方法和所得到的组分。