1,4-bis((4-(2-hydroxyethyl)phenyl)amino)-9,10-anthraquinone | 47772-30-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1,4-bis((4-(2-hydroxyethyl)phenyl)amino)-9,10-anthraquinone
• 英文别名: 1,4-bis((4-(2-hydroxyethyl)phenyl)amino)anthracene-9,10-dione；bis-1,4-(4-hydroxyethylphenylamino)anthraquinone；1,4-bis-(4-(2-hydroxyethyl)phenylamino)-anthraquinone；1,4-bis[4-(2-hydroxyethyl)anilino]anthraquinone；1,4-Bis(4-(2-hydroxyethyl)phenylamino)anthraquinone；1,4-bis[4-(2-hydroxyethyl)anilino]anthracene-9,10-dione
• CAS: 47772-30-5
• 化学式: C₃₀H₂₆N₂O₄
• 分子量: 478.547
• InChiKey: GMJKWGLQXRMWPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  98.7
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,4-bis((4-(2-hydroxyethyl)phenyl)amino)-9,10-anthraquinone 、 4,4'-双甲氧基三苯甲基氯 在 吡啶 作用下， 生成 1-(4-hydroxyethylphenylamino)-4-(DMT-4-hydroxyethylphenylamino)anthraquinone
  参考文献：
  名称：

  [EN] ANTHRAQUINONE QUENCHER DYES, THEIR METHODS OF PREPARATION AND USE
  [FR] COLORANTS EXTINCTEURS DE FLUORESCENCE A BASE D'ANTHRAQUINONE ET PROCEDES DE FABRICATION ET D'UTILISATION

  摘要：

  该发明提供了一种新型蒽醌组合物，可作为广谱荧光猝灭剂，并提供了制备和使用它们的方法。蒽醌猝灭剂可以与各种生物相关化合物结合，包括脂质、核酸、多肽等特异抗原、类固醇、维生素、药物、半抗原、代谢产物、毒素、环境污染物、氨基酸、肽、蛋白质、核苷酸、寡核苷酸、多核苷酸、碳水化合物及其类似物。该发明还提供了包括至少一个本发明的蒽醌猝灭剂染料组合物的工具箱，其中工具箱中包含一个或多个容器，并包含使用该组合物的说明书。

  公开号：

  WO2004026804A1
• 作为产物：
  描述：

  1,4-二羟基蒽醌 在 三乙胺 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 11.0h， 生成 1,4-bis((4-(2-hydroxyethyl)phenyl)amino)-9,10-anthraquinone
  参考文献：
  名称：

  CN116574020

  摘要：

  公开号：

文献信息

• Quencher compositions comprising anthraquinone moieties
  申请人：Lomholt Christian

  公开号：US20050227254A1

  公开（公告）日：2005-10-13

  The present invention provides novel quencher composition comprising anthraquinone quencher moieties. The anthraquinone quencher moieties are useful as quencher labels when attached to biomolecules such as natural or modified polynucleotides, oligonucleotides, nucleosides, nucleotides, carbohydrates and peptides. For example, polynucleotides can be labeled at the 3′ terminus with fluorescence quencher solid support compositions, and polynucleotides can be labeled at internally or at the 5′ terminus. The detectable probes may have a format like molecular beacons, scorpion probes, sunrise probes, conformationally assisted probes and TaqMan probes.

  本发明提供了一种新型猝灭剂组合物，包括蒽醌猝灭剂基团。当连接到生物分子（如天然或改性多聚核苷酸、寡核苷酸、核苷、核苷酸、碳水化合物和肽）时，蒽醌猝灭剂基团可用作猝灭剂标记。例如，多聚核苷酸可在3'端标记荧光猝灭剂固相支持组合物，也可在内部或5'端标记多聚核苷酸。可检测的探针可能具有类似分子信标、蝎子探针、日出探针、构象辅助探针和TaqMan探针的格式。
• Novel methods for quantification of microRNAs and small interfering RNAs
  申请人：Jacobsen Nana

  公开号：US20050272075A1

  公开（公告）日：2005-12-08

  The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.

  本发明涉及核糖核酸、探针和检测、定量以及监测成熟微小RNA和小干扰RNA（siRNA）表达的方法。此外，本发明还涉及监测其他非编码RNA、mRNA剪接变体的表达，以及检测和定量RNA编辑、单个转录本的等位变体、突变、缺失或重复特定外显子的方法，例如与人类疾病如癌症相关的改变。此外，本发明还涉及检测、定量以及监测脱氧核糖核酸的表达的方法。
• Probes, libraries and kits for analysis of mixtures of nucleic acids and methods for constructing the same
  申请人：Ramsing Birger Niels

  公开号：US20060166238A1

  公开（公告）日：2006-07-27

  The invention relates to nucleic acid probes, nucleic acid probe libraries, and kits for detecting, classifying, or quantifying components in a complex mixture of nucleic acids, such as a transcriptome, and methods of using the same. The invention also relates to methods of identifying nucleic acid probes useful in the probe libraries and to methods of identifying a means for detection of a given nucleic acid.

  本发明涉及核酸探针、核酸探针库和用于检测、分类或定量核酸复杂混合物（例如转录组）中的组分的工具箱以及使用它们的方法。本发明还涉及识别有用于探针库的核酸探针的方法，以及识别给定核酸检测手段的方法。
• NOVEL METHODS FOR QUANTIFICATION OF MICRORNAS AND SMALL INTERFERING RNAS
  申请人：Jacobsen Nana

  公开号：US20110076675A1

  公开（公告）日：2011-03-31

  The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.

  本发明涉及到核糖核酸、探针和方法，用于检测、定量以及监测成熟微小RNA和小干扰RNA（siRNA）的表达。此外，本发明还涉及监测其他非编码RNA、mRNA剪接变体的表达，以及检测和定量RNA编辑、单个转录本的等位变体、突变、缺失或转录本中特定外显子的重复等，例如与人类疾病（如癌症）相关的变化。此外，本发明还涉及检测、定量以及监测脱氧核糖核酸的表达方法。
• Anthraquinone quencher dyes, their methods of preparation and use
  申请人：INTEGRATED DNA TECHNOLOGIES, INC.

  公开号：EP2281798A1

  公开（公告）日：2011-02-09

  The invention provides novel anthraquinone compositions that are useful as broad-spectrum quenchers of fluorescence and provides methods for making and using them. The anthraquinone quenchers can be conjugated to a variety of biologically relevant compounds, including lipids, nucleic acids, polypeptides, and more specifically antigens, steroids, vitamins, drugs, haptens, metabolites, toxins, environmental pollutants, amino acids, peptides, proteins, nucleotides, oligonucleotides, polynucleotides, carbohydrates, and their analogs. The invention also provides kits comprising, in one or more containers, at least one anthraquinone quencher dye composition of the present invention, and instructions for using that composition.

  本发明提供了可用作广谱荧光淬灭剂的新型蒽醌组合物，并提供了制造和使用它们的方法。蒽醌淬灭剂可与多种生物相关化合物共轭，包括脂质、核酸、多肽，更具体地说是抗原、类固醇、维生素、药物、催化剂、代谢物、毒素、环境污染物、氨基酸、肽、蛋白质、核苷酸、寡核苷酸、多核苷酸、碳水化合物及其类似物。本发明还提供了包含在一个或多个容器中的至少一种本发明蒽醌淬灭染料组合物的试剂盒，以及该组合物的使用说明。