3-hydroxymethyl-pyridine-2-carboxylic acid | 875256-15-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-hydroxymethyl-pyridine-2-carboxylic acid
• 英文别名: 3-Hydroxymethyl-pyridin-2-carbonsaeure；3-Hydroxymethyl-picolinsaeure；3-(Hydroxymethyl)picolinic acid；3-(hydroxymethyl)pyridine-2-carboxylic acid
• CAS: 875256-15-8
• 化学式: C₇H₇NO₃
• 分子量: 153.137
• InChiKey: SKBJYRPOZXOUIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  70.4
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933399090

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 barium dihydroxide 作用下， 生成 3-hydroxymethyl-pyridine-2-carboxylic acid
  参考文献：
  名称：

  Zincke; Winzheimer, Justus Liebigs Annalen der Chemie, 1896, vol. 290, p. 334

  摘要：

  DOI：

文献信息

• [EN] NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS<br/>[FR] NOUVEAUX COMPOSÉS HÉTÉROARYLIQUES ET HÉTÉROCYCLIQUES, COMPOSITIONS ET PROCÉDÉS
  申请人：HUTCHISON MEDIPHARMA LTD

  公开号：WO2016119707A1

  公开（公告）日：2016-08-04

  The invention relates to novel heteroaryl and heterocycle compounds of formula I and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3K and for treating inflammatory and autoimmune diseases and cancer.

  这项发明涉及公式I的新异芳基和杂环化合物，以及包括它们的药物组合物，用途和方法，用于抑制PI3K的活性，并用于治疗炎症性和自身免疫性疾病以及癌症。
• [EN] PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL<br/>[FR] DÉRIVÉS D'ACIDE PICOLINIQUE ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES ASSOCIÉES À UN TAUX ÉLEVÉ DE CHOLESTÉROL
  申请人：MONTREAL HEART INST

  公开号：WO2020237374A1

  公开（公告）日：2020-12-03

  Formula I The present invention relates to compounds of Formula (I), wherein X is as defined above; Y is OR3; Z is H, optionally substituted alkyl or - CH2OR4; L is optionally substituted alkyl or heteroalkyl; R1 is H, -OH, optionally substituted alkyl, heterocycle, aryl or heteroaryl; R2 is NR5R6, or OR5; each of R3 and R4 is H or optionally substituted alkyl, benzyl, phenyl or heterocycle; or R3 and R4 combine to form an optionally substituted heterocycle; R5 is H or optionally substituted alkyl, cycloalkyl, heteroalkyl, alkylaryl or heterocycle; and R6 is H or alkyl, or pharmaceutically acceptable salts, solvates or compositions thereof. Compounds of formula (I) significantly increase low density lipoprotein receptor expression and activity, lower total circulating cholesterol and are useful for treating and delaying the onset of diseases associated with elevated cholesterol, such as atherosclerosis and hypercholesterolemia.

  本发明涉及以下式（I）的化合物，其中X如上所定义；Y为OR3；Z为H，可选择地取代的烷基或-CH2OR4；L为可选择地取代的烷基或杂环烷基；R1为H，-OH，可选择地取代的烷基，杂环烷基，芳基或杂芳基；R2为NR5R6，或OR5；R3和R4中的每一个为H或可选择地取代的烷基，苄基，苯基或杂环烷基；或R3和R4结合形成可选择地取代的杂环烷基；R5为H或可选择地取代的烷基，环烷基，杂环烷基，烷基芳基或杂环烷基；R6为H或烷基，或其药学上可接受的盐，溶剂或组合物。式（I）的化合物显著增加低密度脂蛋白受体的表达和活性，降低总循环胆固醇，并且对于治疗和延缓与胆固醇升高相关的疾病，如动脉粥样硬化和高胆固醇血症，具有用处。
• Continuous Method For Producing Amides Of Aromatic Carboxylic Acids
  申请人：Krull Matthias

  公开号：US20120095238A1

  公开（公告）日：2012-04-19

  The invention relates to a continuous method for producing amides of aromatic carboxylic acids by reacting at least one carbonic acid ester of formula (I) R 3 —OOOR 4 , wherein R 3 represents an optionally substituted aromatic hydrocarbon group with 5 to 100 carbon atoms and R 4 represents a hydrocarbon group with 1 to 30 carbon atoms, with at least one amine of formula (II) HNR 1 R 2 , wherein R 1 and R 2 independently represent hydrogen or a hydrocarbon group with 1 to 100 C atoms, in a reaction tube the longitudinal axis of which extends in the direction of propagation of the microwaves of a monomode microwave applicator, under microwave irradiation to form carboxamide.

  该发明涉及一种连续方法，通过在至少一种具有式(I) R3—OOOR4的碳酸酯中，其中R3代表一个具有5至100个碳原子的可选择取代的芳香烃基，R4代表一个具有1至30个碳原子的碳氢基团，与至少一种具有式(II) HNR1R2的胺反应，其中R1和R2独立地代表氢或具有1至100个C原子的碳氢基团，在一个反应管中，在单模微波应用器的微波传播方向上的纵轴下，通过微波辐射形成羧酰胺。
• Method For Producing Amides In The Presence Of Superheated Water
  申请人：Krull Matthias

  公开号：US20110089021A1

  公开（公告）日：2011-04-21

  The invention relates to a method for producing carboxylic acid amides, according to which at least one carboxylic acid of formula (I) R 3 —COON   (I) wherein R 3 is hydrogen or an optionally substituted hydrocarbon radical comprising between 1 and 50 carbon atoms, is reacted with at least one amine of formula (II) HNR 1 R 2 (II) wherein R 1 and R 2 are independently hydrogen or an optionally substituted hydrocarbon radical comprising between 1 and 100 C atoms, to form an ammonium salt, and said ammonium salt is reacted in the presence of superheated water, under microwave irradiation, to form a carboxylic acid amide.

  该发明涉及一种生产羧酸酰胺的方法，根据该方法，至少一种具有以下结构的羧酸（I）R3—COON（I）其中R3是氢或含有1至50个碳原子的可选择取代的烃基，与至少一种具有以下结构的胺（II）HNR1R2（II）其中R1和R2独立地是氢或含有1至100个碳原子的可选择取代的烃基，反应形成一种铵盐，然后在超热水存在下，在微波辐射下，将该铵盐反应形成一种羧酸酰胺。
• Continuous Method For Producing Amides of Aromatic Carboxylic Acids
  申请人：Krull Matthias

  公开号：US20110089019A1

  公开（公告）日：2011-04-21

  The invention relates to a continuous method for producing amides of aromatic carboxylic acids, according to which at least one aromatic carboxylic acid of formula (I) Ar—COON   (I) wherein Ar is an optionally substituted aryl radical comprising between 5 and 50 atoms, is reacted with at least one amine of formula (II) HNR 1 R 2 (II) wherein R 1 and R 2 are independently hydrogen or a hydrocarbon radical comprising between 1 and 100 C atoms, to form an ammonium salt, and said ammonium salt is then reacted to form a carboxylic acid amide, under microwave irradiation in a reaction pipe, the longitudinal axis of the pipe being oriented in the direction of propagation of the microwaves of a monomode microwave applicator.

  该发明涉及一种连续生产芳香羧酸酰胺的方法，根据该方法，将式(I)Ar—COON中的至少一种芳香羧酸（其中Ar是一个可选择取代的含有5至50个原子的芳基基团）与式(II)HNR1R2中的至少一种胺（其中R1和R2独立地是氢或含有1至100个碳原子的烃基团）反应，形成铵盐，然后将所述铵盐反应形成羧酸酰胺，在一个反应管中通过微波辐射，管的纵轴沿着单模微波应用器的微波传播方向定向。