(S)-1-(methylamino)propan-2-ol | 70377-76-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (S)-1-(methylamino)propan-2-ol
• 英文别名: (2S)-1-(methylamino)propan-2-ol；(S)-N-Methyl-2-hydroxypropylamine
• CAS: 70377-76-3
• 化学式: C₄H₁₁NO
• mdl: MFCD19217901
• 分子量: 89.1374
• InChiKey: AEKHFLDILSDXBL-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险类别：
  8
• 危险性防范说明：
  P501,P273,P270,P210,P264,P280,P370+P378,P303+P361+P353,P301+P330+P331,P363,P301+P312+P330,P304+P340+P310,P305+P351+P338+P310,P403+P235,P405
• 危险品运输编号：
  2735
• 危险性描述：
  H302+H312,H314,H412,H227
• 包装等级：
  II

反应信息

• 作为反应物：
  描述：

  (S)-1-(methylamino)propan-2-ol 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.5h， 以14%的产率得到N-[(2S)-2-hydroxypropyl]-N,2,3-trimethyl-1',3,3',6,7,9-hexahydrospiro[imidazo[4,5-h]-quinoline-8,2'-indene]-5-carboxamide
  参考文献：
  名称：

  WO2006/134111

  摘要：

  公开号：
• 作为产物：
  描述：

  (S) lactic acid N-methyl amide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 (S)-1-(methylamino)propan-2-ol
  参考文献：
  名称：

  Unusually facile solvolysis of primary tosylates. A case for participation by the N-nitroso group

  摘要：

  DOI：

  10.1021/jo01329a025

文献信息

• [EN] SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME<br/>[FR] COMPOSÉS 1,1'-BIPHÉNYLE SUBSTITUÉS ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ARBUTUS BIOPHARMA INC

  公开号：WO2021158481A1

  公开（公告）日：2021-08-12

  The present invention includes substituted 1,1'-biphenyl compounds, analogues thereof, and compositions comprising the same. In one aspect, the compounds contemplated in the invention can be used to treat, ameliorate, or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. In another aspect, the compounds contemplated in the invention can be used to treat, ameliorate, and/or prevent cancer in a patient.

  本发明包括取代的1,1'-联苯化合物，其类似物，以及包含它们的组合物。在一个方面，本发明中考虑的化合物可用于治疗、改善或预防患者体内的乙型肝炎病毒（HBV）和/或丙型肝炎病毒（HDV）感染。在另一个方面，本发明中考虑的化合物可用于治疗、改善和/或预防患者体内的癌症。
• [EN] NOVEL BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF MAKING AND USING SAME<br/>[FR] NOUVEAUX COMPOSÉS DE MODULATION DE RÉGULATION DE RESPIRATION ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：GALLEON PHARMACEUTICALS INC

  公开号：WO2017003822A1

  公开（公告）日：2017-01-05

  The present invention includes compounds that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound and/or composition of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound and/or composition of the invention.

  本发明涵盖了对需要的受试者预防和/或治疗呼吸控制疾病或紊乱的化合物。本发明还包括一种预防和/或治疗受试者呼吸系统疾病或紊乱的方法，包括向受试者施用本发明的化合物和/或组合物的治疗有效量。本发明还包括一种预防呼吸节律不稳定或稳定的方法，包括向受试者施用本发明的化合物和/或组合物的治疗有效量。
• SUBSTITUTED PYRIDOBENZODIAZEPINONE-DERIVATIVES AND USE THEREOF
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：US20170253602A1

  公开（公告）日：2017-09-07

  The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders in which neovascularization plays a role, for example ophthalmological disorders and cancers and tumours. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.

  本申请涉及新型(3-羟基苯基)氨基取代的吡啶并[2,3-b][1,5]苯二氮杂二环己酮衍生物，以及其制备方法，单独或联合用于治疗和/或预防疾病的用途，以及用于生产用于治疗和/或预防疾病的药物的用途，特别是对血管生成障碍和细胞过度增殖障碍的治疗，其中新生血管化起作用，例如眼科疾病和癌症和肿瘤。这种治疗可以作为单独治疗或与其他药物或进一步治疗措施结合使用。
• New chiral mixed AMPP ligands and their use in asymmetric hydrogenation of activated ketones on rhodium catalysts
  作者：Corinne Hatat、Nicolas Kokel、André Mortreux、Francis Petit

  DOI：10.1016/s0040-4039(00)97563-4

  日期：1990.1

  Chiral bidentate aminophosphinephosphinites (AMPP) ligands bearing different substituents at the aminophosphine and the phosphinite moieties are prepared in a one pot synthesis from aminoalcohols. Their use in asymmetric hydrogenation of activated ketones is described. Upon analysis of these results, it is suggested that the phosphinamido group governs both the activity and the enantioselectivity of

  在氨基醇的一锅法合成中制备在氨基膦和次膦酸酯部分带有不同取代基的手性二齿氨基膦次膦酸酯（AMPP）配体。描述了它们在活化酮的不对称氢化中的用途。根据这些结果的分析，建议膦酰胺基控制该反应的活性和对映选择性。
• 7-SUBSTITUTED 1-ARYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF
  申请人：Bayer Aktiengesellschaft

  公开号：US20190263805A1

  公开（公告）日：2019-08-29

  The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.

  本申请涉及新颖的7-取代的1-芳基喹啉并吡啶-3-羧酰胺，其制备方法，其单独或组合使用，用于治疗和/或预防疾病，以及用于生产药物以治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病和/或肾脏疾病。