(+/-)-formic acid-(1-methyl-2-phenyl-ethyl ester) | 42006-80-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+/-)-formic acid-(1-methyl-2-phenyl-ethyl ester)
• 英文别名: (+/-)-Ameisensaeure-(1-methyl-2-phenyl-aethylester)；1-Phenylpropan-2-yl formate
• CAS: 42006-80-4
• 化学式: C₁₀H₁₂O₂
• 分子量: 164.204
• InChiKey: FQRIQDIZNSOSAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  甲酸 、 (+/-)-formic acid-(1-methyl-2-phenyl-ethyl ester) 在 silica gel 作用下， 反应 0.07h， 以92%的产率得到1-苯基-2-丙醇
  参考文献：
  名称：

  Ghorbani-Vaghei, Ramin; Veisi, Hojat; Amiri, Mostafa, South African Journal of Chemistry, 2009, vol. 62, p. 39 - 43

  摘要：

  DOI：
• 作为产物：
  描述：

  在 碳酸氢钠 作用下， 反应 0.25h， 生成 (+/-)-formic acid-(1-methyl-2-phenyl-ethyl ester)
  参考文献：
  名称：

  加合物：用于合成酰亚胺和am的多功能试剂

  摘要：

  由叔和仲脂肪族和芳香族酰胺以及三氟甲磺酸酐（Tf 2 O）生成的Vilsmeier试剂与不同的亲核试剂（ROH，RSH，RNH 2）反应，得到相对的亚胺鎓盐和am鎓盐。前者，在室温下稳定，通过用OH处理很容易转变成相应的酯或O-烷基硫酯-或SH - 。

  DOI：

  10.1016/s0040-4039(97)10642-6

文献信息

• Acetylation and Formylation of Alcohols in the Presence of Silica Sulfuric Acid
  作者：Farhad Shirini、Mohammad Ali Zolfigol、Kamal Mohammadi

  DOI：10.1080/10426500307877

  日期：2003.7

  Alcohols are converted to esters in a mild, clean, and efficient reaction with acetic and formic acids in the presence of silica sulfuric acid. All reactions were performed under mild and completely heterogeneous conditions in refluxing n-hexane.

  在二氧化硅硫酸的存在下，醇与乙酸和甲酸通过温和、清洁和有效的反应转化为酯。所有反应均在温和且完全非均相的回流正己烷条件下进行。
• Silica Triflate as an Efficient Reagent for the Chemoselective Formylation of Alcohols
  作者：Farhad Shirini、Katayoun Marjani、Hossein Taherpour Nahzomi、Mohammad Ali Zolfigol

  DOI：10.1080/10426500601160710

  日期：2007.4.19

  Silica triflate, as a new and stable silica-based reagent, is prepared by a reaction of silica gel with trifluoromethane sulfonyl chloride at room temperature. This reagent can be used for the efficient and selective formylation of alcohols in the presence of phenols in a relatively short reaction time and high yields under heterogeneous reaction conditions.

  三氟甲磺酸二氧化硅是一种新型稳定的二氧化硅基试剂，由硅胶与三氟甲磺酰氯在室温下反应制备。该试剂可用于在酚类存在下，在非均相反应条件下以相对较短的反应时间和高产率对醇进行有效和选择性的甲酰化。
• Method for producing a modified peptide
  申请人：Minamitake Yoshiharu

  公开号：US20050131208A1

  公开（公告）日：2005-06-16

  The present invention is a method for producing a peptide or a protein in which a side chain contains a modified amino acid residue, which comprises chemically producing a peptide fragment containing an amino acid residue having a modified side chain using an weak acid-cleavable resin, producing a peptide fragment containing no amino acid residue having a modified side chain using a genetic recombination method or/and an enzymatic method, and condensing the resulting two kinds of peptide fragments and, according to the present invention, a peptide or a protein containing modification such as acylation, glycosylation and phosphorylation can be obtained effectively and at high quality.

  本发明是一种制备侧链含有修饰氨基酸残基的肽或蛋白质的方法，其包括使用弱酸可裂解树脂化学制备含有修饰侧链氨基酸残基的肽片段，使用基因重组方法和/或酶法制备不含有修饰侧链氨基酸残基的肽片段，将两种肽片段进行缩合。根据本发明，可以有效地高质量地获得包含酰化、糖基化和磷酸化等修饰的肽或蛋白质。
• Pyrimidine derivatives
  申请人：Sato Michitaka

  公开号：US20070197551A1

  公开（公告）日：2007-08-23

  This invention provides pyrimidine derivatives represented by a formula, in the formula, ring A stands for carbocyclic group or heterocyclic group, X 1 stands for hydrogen, lower alkyl, amino, etc., X 2 stands for hydrogen or lower alkyl, Y stands for a direct bond or sulfur or nitrogen, n stands for an integer of 0-4, and Ar stands for a group of the following formula, or a salt thereof, which concurrently exhibit 5-HT 1A agonistic activity and 5-HT 3 antagonistic activity and are useful for therapy and treatments of diseases such as IBS. The invention furthermore provides a therapeutic method of IBS, characterized by having 5-HT 1A agonistic activity and 5-HT 3 antagonistic activity work simultaneously and cooperatively in vivo, which comprises either administering 5-HT 3 antagonistic agent which concurrently exhibits 5-HT 1A agonistic activity, or administering 5-HT 1A agonistic agent and 5-HT 3 antagonistic agent simultaneously, in sequence or at an interval.

  本发明提供了由下式表示的嘧啶衍生物，其中，环A代表碳环基团或杂环基团，X1代表氢、低碳基、氨基等，X2代表氢或低碳基，Y代表直接键或硫或氮，n代表0-4的整数，Ar代表以下式的基团，或其盐，同时表现出5-HT1A激动活性和5-HT3拮抗活性，并且对治疗诸如肠易激综合征等疾病有用。本发明进一步提供了一种IBS治疗方法，其特征在于在体内同时和协同地发挥5-HT1A激动活性和5-HT3拮抗活性，包括给予同时表现出5-HT1A激动活性和5-HT3拮抗活性的5-HT3拮抗剂，或同时给予5-HT1A激动剂和5-HT3拮抗剂，按顺序或间隔给予。
• Methods for preparing anti-hypertensive agents
  申请人：UNIVERSITY OF MIAMI

  公开号：EP0038117A1

  公开（公告）日：1981-10-21

  A plurality of methods are disclosed for preparing compounds having the formula: wherein R is hydrogen, formyl, acetyl, propanoyl, butanoyl, phenylacetyl, phenylpropanoyl, benzoyl, cyclopentanecarbonyl, tert-butyloxycarbonyl, cyclopentanecarbonyl-L-lysyl, pyro-L-glutamyl-L-lysyl, L-lysyl, L-arginyl or pyro-L-glutamyl; A is phenylalanyl, alanyl, tryptophyl, tyrosyl, glycyl isoleucyl, leucyl, histidyl, or valyl, the α-amino group thereof being in amide linkage with R; R1 is hydrogen or methyl, R2 is L-proline, L-3,4-dehydroproline, D,L-3,4-dehydro- proline, L-3-hydroxyproline, L-4-hydroxyproline, L-thiazo- lidine-4-carboxylic acid, or L-5-oxo-proline, the imino group thereof being in imide linkacge with the adiacent and, I n is 0 or 1, such that when n is O, R is methyl, and where n=1, and R1 is methyl the moiety is in the D-configuration. These compounds are inhibitors of angiotensin converting enzyme.

  本发明公开了制备具有以下式子的化合物的多种方法： 其中 R是氢、甲酰基、乙酰基、丙酰基、丁酰基、苯乙酰基、苯丙酰基、苯甲酰基、环戊羰基、叔丁氧羰基、环戊羰基-L-赖氨酰、吡咯-L-谷氨酰-L-赖氨酰、L-赖氨酰、L-精氨酰或吡咯-L-谷氨酰； A 是苯丙氨酰、丙氨酰、色氨酰、酪氨酰、甘氨酰异亮氨酰、亮氨酰、组氨酰或缬氨酰，其 α-氨基与 R 呈酰胺连接； R1 是氢或甲基 R2 是 L-脯氨酸、L-3,4-脱氢脯氨酸、D,L-3,4-脱氢脯氨酸、L-3-羟基脯氨酸、L-4-羟基脯氨酸、L-噻唑-脯氨酸-4-羧酸或 L-5-氧代脯氨酸，其中的亚氨基与邻位的亚氨基连接 和 I n 为 0 或 1，当 n 为 O 时，R 为甲基；当 n=1 时，R1 为甲基。 分子为 D-构型。这些化合物是血管紧张素转换酶的抑制剂。