1,3-bis-[(hydroxymethyl)(pyridine-2-yl)phosphino]propane | 1438430-40-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,3-bis-[(hydroxymethyl)(pyridine-2-yl)phosphino]propane
• 英文别名: 1,3-bis-[hydroxymethyl(pyridine-2-yl)phosphino]propane
• CAS: 1438430-40-0
• 化学式: C₁₅H₂₀N₂O₂P₂
• 分子量: 322.284
• InChiKey: ZJXKGJOFPCARHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.68
• 重原子数：
  21.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.24
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1,3-bis-[(hydroxymethyl)(pyridine-2-yl)phosphino]propane 、 异丙胺 以 甲苯 为溶剂， 反应 15.0h， 以11%的产率得到1,9-diisopropyl-3,7,11,15-tetrapyridyl-1,9-diaza-3,7,11,15-tetraphosphacyclohexadecane
  参考文献：
  名称：

  Synthesis of a 16-Membered P4N2 Macrocycle with Pyridyl-Substituted Phosphorus Atoms

  摘要：

  The first example of 16-membered aminomethylphosphines with pyridyl substituents on the phosphorus atom was synthesized as an RSSR isomer by covalent self-assembly in the system 1,3-bis[(pyridin-2-yl)phosphino]propane-formaldehyde-isopropylamine.

  DOI：

  10.1134/s1070363218110336
• 作为产物：
  描述：

  2-pyridylphosphine 在 potassium hydroxide 作用下， 以 水 、 二甲基亚砜 为溶剂， 生成 1,3-bis-[(hydroxymethyl)(pyridine-2-yl)phosphino]propane
  参考文献：
  名称：

  Synthesis of Bis(2-Pyridylphosphino)Alkanes in Superbasic Medium and Their Hydroxymethyl Derivatives

  摘要：

  Novel P-H-diphosphinoalkanes with pyridyl substituents at the phosphorus atoms have been obtained in good or moderate yields by the interaction of primary 2-pyridyl-phosphine with dichloroalkanes in superbasic medium. The formation of novel 1-(2-pyridyl)-1-phosphacyclopentane together with bis(2-pyridylphosphino)butane was observed as the result of the interaction of 2-pyridylphosphine and 1,4-dichlorobutane under the same reaction conditions. The reaction of the bis(2-pyridylphosphino)alkanes thus obtained with formaldehyde leads to the formation of the corresponding hydroxymethyl derivatives.

  DOI：

  10.1080/10426507.2012.729118