carbonic acid 5-ethynyl-2-triisopropylsilanyloxy-benzyl ester 2-oxo-2H-chromen-7-yl ester | 1145732-50-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: carbonic acid 5-ethynyl-2-triisopropylsilanyloxy-benzyl ester 2-oxo-2H-chromen-7-yl ester
• 英文别名: [5-Ethynyl-2-tri(propan-2-yl)silyloxyphenyl]methyl (2-oxochromen-7-yl) carbonate；[5-ethynyl-2-tri(propan-2-yl)silyloxyphenyl]methyl (2-oxochromen-7-yl) carbonate
• CAS: 1145732-50-8
• 化学式: C₂₈H₃₂O₆Si
• 分子量: 492.644
• InChiKey: IXCWPXBXMAJRKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.04
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  carbonic acid 5-ethynyl-2-triisopropylsilanyloxy-benzyl ester 2-oxo-2H-chromen-7-yl ester 在 四丁基氟化铵 作用下， 以 二氯甲烷 为溶剂， 以100%的产率得到Umbelliferone
  参考文献：
  名称：

  Kinetics of Self-Immolation: Faster Signal Relay over a Longer Linear Distance?

  摘要：

  A counterintuitive observation of a faster signal relay over a longer linear distance prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient "shortcut" that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination.

  DOI：

  10.1021/ol900433g
• 作为产物：
  描述：

  、 (5-ethynyl-2-(triisopropylsilyloxy)phenyl)methanol 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以0.074 g的产率得到carbonic acid 5-ethynyl-2-triisopropylsilanyloxy-benzyl ester 2-oxo-2H-chromen-7-yl ester
  参考文献：
  名称：

  Kinetics of Self-Immolation: Faster Signal Relay over a Longer Linear Distance?

  摘要：

  A counterintuitive observation of a faster signal relay over a longer linear distance prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient "shortcut" that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination.

  DOI：

  10.1021/ol900433g

文献信息

• Kinetics of Self-Immolation: Faster Signal Relay over a Longer Linear Distance?
  作者：Ho Yong Lee、Xuan Jiang、Dongwhan Lee

  DOI：10.1021/ol900433g

  日期：2009.5.21

  A counterintuitive observation of a faster signal relay over a longer linear distance prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient "shortcut" that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination.