2-[(4-methylphenyl)sulfonylamino]-N-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(4-methylphenyl)sulfonylamino]-N-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
• 化学式: C₂₂H₂₂N₂O₃S₂
• 分子量: 426.56
• InChiKey: LAIGEMHNAVBYQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[(4-methylphenyl)sulfonylamino]-N-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 在 水 作用下， 生成 2-tosylamino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid 、 苯胺
  参考文献：
  名称：

  4,5-（芳基，烷基）-3-取代的2-氨基噻吩磺酰基衍生物的理化性质

  摘要：

  已经研究了4，5-（芳基，烷基）-3-取代的2-磺酰基氨基噻吩的理化性质。研究了噻吩环中取代基的性质对酸碱性质，溶解度和化学稳定性的影响。

  DOI：

  10.1134/s1070363217030094
• 作为产物：
  描述：

  2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid phenyl-amide 、 对甲苯磺酰氯 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 生成 2-[(4-methylphenyl)sulfonylamino]-N-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
  参考文献：
  名称：

  Complexing Properties of 3-Substituted-2-(aryl-, methyl)sulfonylamino-4,5,6,7-tetrahydrobenzo[b]thiophenes with Nonferrous Metal Ions in Ammonia Media

  摘要：

  The complexation of 3-substituted-2-(aryl-,methyl)sulfonylamino-4,5,6,7-tetrahydrobenzo[b]thiophenes with Cu(II), Co(II), and Ni(II) ions in ammonia media was studied. Different types of complexes with Cu(II) ions were found depending on pH: with a ratio of 1:2 at pH of similar to 4-5 and 1:1 at pH of similar to 8-10. For the Co(II) and Ni(II) ions, the formation of 1:1 complexes at pH of similar to 9-10 was established. The Cu(II), Co(II), and Ni(II) complexes [Cu(HL)(2)center dot 2H(2)O] and [ML center dot 2H(2)O] were separated and identified, and their solubility products were calculated. The effect of the nature of the functional group in the third position of the thiophene ring on the properties of the complexes of reagents with nonferrous metal ions was shown.

  DOI：

  10.1134/s003602361807015x

文献信息

• Complexing Properties of 3-Substituted-2-(aryl-, methyl)sulfonylamino-4,5,6,7-tetrahydrobenzo[b]thiophenes with Nonferrous Metal Ions in Ammonia Media
  作者：K. O. Manylova、L. G. Chekanova、P. T. Pavlov、E. V. Baigacheva

  DOI：10.1134/s003602361807015x

  日期：2018.7

  The complexation of 3-substituted-2-(aryl-,methyl)sulfonylamino-4,5,6,7-tetrahydrobenzo[b]thiophenes with Cu(II), Co(II), and Ni(II) ions in ammonia media was studied. Different types of complexes with Cu(II) ions were found depending on pH: with a ratio of 1:2 at pH of similar to 4-5 and 1:1 at pH of similar to 8-10. For the Co(II) and Ni(II) ions, the formation of 1:1 complexes at pH of similar to 9-10 was established. The Cu(II), Co(II), and Ni(II) complexes [Cu(HL)(2)center dot 2H(2)O] and [ML center dot 2H(2)O] were separated and identified, and their solubility products were calculated. The effect of the nature of the functional group in the third position of the thiophene ring on the properties of the complexes of reagents with nonferrous metal ions was shown.
• Physicochemical properties of 4,5-(aryl,alkyl)-3-substituted 2-aminothiophenes sulfonyl derivatives
  作者：L. G. Chekanova、K. O. Manylova、P. T. Pavlov、A. N. Vasyanin、S. N. Shurov、O. A. Maiorova

  DOI：10.1134/s1070363217030094

  日期：2017.3

  Physicochemical properties of 4,5-(aryl, alkyl)-3-substituted 2-sulfonylaminothiophenes have been studied. The effect of the nature of the substituents in the thiophene ring on acid-base properties, solubility, and chemical stability was investigated.

  已经研究了4，5-（芳基，烷基）-3-取代的2-磺酰基氨基噻吩的理化性质。研究了噻吩环中取代基的性质对酸碱性质，溶解度和化学稳定性的影响。