4-Acetamino-naphthalsaeure-butylimid | 3353-99-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 4-Acetamino-naphthalsaeure-butylimid
• 英文别名: N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-benz[de]isoquinolin-6-yl)-acetamide；N-(2-Butyl-1,3-dioxo-2,3-dihydro-1H-benz[de]isochinolin-6-yl)-acetamid；N-(2-Butyl-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-6-yl)acetamide；N-(2-butyl-1,3-dioxobenzo[de]isoquinolin-6-yl)acetamide
• CAS: 3353-99-9
• 化学式: C₁₈H₁₈N₂O₃
• 分子量: 310.353
• InChiKey: TXYZROWNGUGODG-UHFFFAOYSA-N

物化性质

• 熔点：
  231-232 °C(Solv: acetic acid (64-19-7))
• 沸点：
  562.6±33.0 °C(Predicted)
• 密度：
  1.291±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  66.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-butyl-4-nitro-1,8-naphthalimide 在 吡啶 作用下， 生成 4-Acetamino-naphthalsaeure-butylimid
  参考文献：
  名称：

  Alexiou, Michael S.; Tychopoulos, Vasiliki; Ghorbanian, Shohreh, Journal of the Chemical Society. Perkin transactions II, 1990, # 5, p. 837 - 842

  摘要：

  DOI：

文献信息

• A Facile, Versatile, and Highly Efficient Strategy for Peroxynitrite Bioimaging Enabled by Formamide Deformylation
  作者：Xilei Xie、Guangzhao Liu、Xingxing Su、Yong Li、Yawen Liu、Xiaoyun Jiao、Xu Wang、Bo Tang

  DOI：10.1021/acs.analchem.9b01175

  日期：2019.5.21

  Peroxynitrite (ONOO–) is attracting increasing attention due to its involvement in multiple facets of pathophysiological processes. However, ONOO– bioimaging is still challenging due to (1) the lack of highly specific reaction triggers, (2) the tedious and low-yielding synthesis of current sophisticated probes, and (3) the lack of availability of a versatile chemical strategy. To address these challenges, on the basis of amine formylation/deformylation chemistry, we have developed a novel strategy for ONOO– bioimaging. As proof of principle, we designed, synthesized, and evaluated four novel fluorescent probes equipped with the formamide functionality. Although they feature distinctly different fluorophore classes, all probes can be synthesized in one step in high yields and exhibit particularly specific, highly sensitive, and rapid responses to ONOO–. The bioimaging capability is well demonstrated by successfully visualizing ONOO– fluctuation in live cells and major organs of mice suffering from paraquat poisoning. The proposed strategy has proved to be a facile, versatile, and highly efficient methodology for ONOO– visualization, which will greatly facilitate ONOO– biochemistry and pathophysiology.

  过氧亚硝酸盐（ONOO–）因其在病理生理过程中的多重作用而越来越受到关注。然而，由于（1）缺乏高特异性的反应触发剂，（2）目前复杂探针的合成过程繁琐且产率低，以及（3）缺乏通用的化学策略，ONOO–生物成像仍然面临挑战。为了解决这些问题，我们基于胺的甲酰化/去甲酰化化学，开发了一种用于ONOO–生物成像的新策略。作为原理的证明，我们设计、合成并评估了四种具有甲酰胺功能的荧光探针。尽管它们具有明显不同的荧光团类别，但所有探针均可在一步内高产率合成，并对ONOO–表现出特别特异、高灵敏和快速的响应。通过成功可视化因巴拉克毒素中毒的小鼠活细胞和主要器官中的ONOO–波动，生物成像能力得到了良好的验证。所提出的策略已证明是一种简单、多功能且高效的ONOO–可视化方法，将极大推动ONOO–生物化学和病理生理学的发展。
• Water-sensitive ratiometric fluorescent probes and application to test strip for rapid and reversible detection of water
  作者：Shin A Yoon、Ju Hyun Oh、Sung Kuk Kim、Min Hee Lee

  DOI：10.1016/j.dyepig.2019.02.052

  日期：2019.6

  in the dual emission and a visual fluorescent color change depending on the water contents in organic solvents, including ethanol, methanol, acetonitrile and DMF solvents. Moreover, the 1-impregnated paper strips showed a rapid and easy-to-visualize fluorescent color change enabling water detection in organic solvents. These simple-to-use paper strips were also found to be reusable over 20 times.

  开发了萘二甲酰亚胺修饰的氟化乙酰胺1和2作为溶剂敏感型双发射荧光探针。特别是，1呈现双发射超过其他各种有机溶剂为水，DMF，DMSO等溶剂中具有大的斯托克斯位移。双重发射可能是由于通过二氟乙酰胺基团与溶剂分子的缔合，萘二甲酰亚胺部分的分子内电荷转移（ICT）的增加。该1可以产生在双发射一个比率的变化和取决于在有机溶剂，包括乙醇，甲醇，乙腈和DMF溶剂中的水含量的可视荧光颜色变化。而且，1浸渍纸条显示出快速且易于观察的荧光色变化，从而能够检测有机溶剂中的水。还发现这些易于使用的纸带可重复使用20次以上。
• A naphthalimide-based probe for phosgene sensing based on the phosgene-induced beckmann rearrangement
  作者：Yue-Lin Huang、Wei Ye、Yue-Ting Su、Zhen-Yi Wu、Hong Zheng

  DOI：10.1016/j.dyepig.2019.107854

  日期：2020.2

  based on the mechanism of the phosgene-induced Beckmann rearrangement of the naphthalimide fluorophore. An electron-withdrawing ketoxime, which was used as the phosgene receptor, was attached to the 4-position on the 1,8-naphthalimide chromophore to constituted a nonfluorescent probe. The reaction of phosgene with ketoxime induced a Beckmann rearrangement, which was followed by conversion of the nonfluorescent

  开发了一种用于乙腈中选择性和灵敏的光气传感的新探针。感测机制是基于光气引起的萘二甲酰亚胺荧光团的贝克曼重排的机制。将用作光气受体的吸电子酮肟连接到1,8-萘二甲酰亚胺生色团的4位上，以构成非荧光探针。光气与酮肟的反应引起贝克曼重排，随后将非荧光探针转换为4-乙酰氨基-1,8-萘二甲酰亚胺荧光团，该荧光团在488 nm处发出明亮的蓝色荧光。该探针对光气的检测极限为6.3 nM。此外，还展示了用于成功监测气态光气的装有探针的滤纸条。
• An organic thin-film el device
  申请人：NEC CORPORATION

  公开号：EP0398764A2

  公开（公告）日：1990-11-22

  An organic thin-film electroluminescence (=EL) device is provided. This device includes as a main constituent of an organic luminescent thin-film layer sandwiched between a couple of electrodes at least one of which is transparent, a naphthalimide derivative represented by the formula (I): wherein R₁, R₂ and R₃ are identical or different from each other and are selected from the group consisting of hydrogen, an alkyl group, an aryl group, a substituted alkyl group, a substituted aryl group, an alkoxyl group, an amino group and an acylamino group.

  提供了一种有机薄膜电致发光（=EL）装置。该装置包括夹在两个电极（其中至少一个是透明的）之间的有机发光薄膜层，其主要成分是由式（I）表示的萘二甲酰亚胺衍生物： 其中 R₁、R₂ 和 R₃ 彼此相同或不同，并且选自由氢、烷基、芳基、取代的烷基、取代的芳基、烷氧基、氨基和酰氨基组成的组。
• INTERLAYER FILM FOR LAMINATED GLASS, AND LAMINATED GLASS
  申请人：Sekisui Chemical Co., Ltd.

  公开号：EP3202737A1

  公开（公告）日：2017-08-09

  The present invention aims to provide an interlayer film for laminated glass which prevents a double image phenomenon in a specific area of laminated glass and enables display of high contrast images at a luminance within a certain range. The present invention also aims to provide a laminated glass including the interlayer film for laminated glass. The present invention relates to an interlayer film for laminated glass, having a multilayer structure including a luminescent layer and a resin layer on at least one surface of the luminescent layer. The luminescent layer contains a thermoplastic resin, a plasticizer, and a luminescent material. The resin layer contains a thermoplastic resin and a plasticizer. The interlayer film for laminated glass has a wedge-shaped cross-sectional shape. The luminescent layer has a difference between the maximum thickness and the minimum thickness of 100 µm or less.

  本发明旨在提供一种夹层玻璃用中间膜，它能防止夹层玻璃特定区域出现重影现象，并能在一定亮度范围内显示高对比度图像。本发明还旨在提供一种夹层玻璃，其中包括用于夹层玻璃的中间膜。本发明涉及一种夹层玻璃用中间膜，它具有多层结构，包括发光层和发光层至少一个表面上的树脂层。发光层包含热塑性树脂、增塑剂和发光材料。树脂层包含热塑性树脂和增塑剂。夹层玻璃用中间膜的横截面形状为楔形。发光层的最大厚度与最小厚度之差不超过 100 微米。