N-octadecylbenzene-1,2-diamine | 95745-99-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-octadecylbenzene-1,2-diamine
• 英文别名: N-octadecyl-1,2-benzenediamine；2-N-octadecylbenzene-1,2-diamine
• CAS: 95745-99-6
• 化学式: C₂₄H₄₄N₂
• 分子量: 360.627
• InChiKey: AKKQIZPOXUJJQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  26
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-octadecylbenzene-1,2-diamine 在 palladium on activated charcoal 氢气 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 乙醇 、 乙腈 为溶剂， 生成 N,N'''-Bis-(2-octadecylamino-phenyl)-benzene-1,2,4,5-tetraamine
  参考文献：
  名称：

  四氮杂并五苯分子单分子层的结构

  摘要：

  发现独特的四氮杂并五苯两性离子两亲物的 Langmuir 分子单分子层形成对施加的磁场强烈响应的条状域。这些条纹域作为 Langmuir-Blodgett (LB) 薄膜转移到玻璃基板上，在那里使用五种互补成像技术对它们进行结构表征，包括扫描二次谐波 (SHG) 显微镜和电容力显微镜。四氮杂并五苯单分子层的相邻单条带域的分子取向通过 SHG 偏振测量确定。这些结构在各种成像技术中被证明是一致的。

  DOI：

  10.1021/jp0155415
• 作为产物：
  描述：

  十八胺 在 palladium on activated charcoal 氢气 、 N,N-二异丙基乙胺 、 二乙二醇 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 N-octadecylbenzene-1,2-diamine
  参考文献：
  名称：

  四氮杂并五苯分子单分子层的结构

  摘要：

  发现独特的四氮杂并五苯两性离子两亲物的 Langmuir 分子单分子层形成对施加的磁场强烈响应的条状域。这些条纹域作为 Langmuir-Blodgett (LB) 薄膜转移到玻璃基板上，在那里使用五种互补成像技术对它们进行结构表征，包括扫描二次谐波 (SHG) 显微镜和电容力显微镜。四氮杂并五苯单分子层的相邻单条带域的分子取向通过 SHG 偏振测量确定。这些结构在各种成像技术中被证明是一致的。

  DOI：

  10.1021/jp0155415

文献信息

• Benzimidazole derivative, hair growth promoter and external composition for skin using the same
  申请人：Shiseido Co., Ltd.

  公开号：US06204264B1

  公开（公告）日：2001-03-20

  A benzimidazole derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C10-30 expressed by R1 and the other is —(CH2)n—NR2R3; R2 and R3 individually represent H, lower alkyl, phenyl or benzyl, or —NR2R3 may be a heterocycle having 3-7 members, or —CONR5—(CH2)n—NR2R3 may be the following Group (W): wherein R2 is H, lower alkyl, phenyl or benzyl and ring E is a heterocycle of 6 or 7 members; R4 is selected from the group consisting of H, halogen, cyano, trifluoromethyl, lower alkyl and etc.; R5 is H, lower alkyl, lower acyl or lower alkylcarbamoyl; m is 0 or 1; and n is an integer of 0-5. The benzimidazole derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

  一种苯并咪唑衍生物或其盐，由以下式（I）表示：其中A和B中的一个是由R1表示的C10-30的烃基，另一个是—（CH2）n—NR2R3；R2和R3分别代表H、较低的烷基、苯基或苄基，或者—NR2R3可以是具有3-7个成员的杂环，或者—CONR5—（CH2）n—NR2R3可以是以下的基团（W）：其中R2为H、较低的烷基、苯基或苄基，环E为6或7个成员的杂环；R4选自H、卤素、氰基、三氟甲基、较低的烷基等组成的群；R5为H、较低的烷基、较低的酰基或较低的烷基甲酰基；m为0或1；n为0-5的整数。该苯并咪唑衍生物或其盐具有出色的促进头发生长和再生的效果，可用于哺乳动物的护理、改善或预防脱发，特别是人类。
• A New Discovery of Unique 13-(Benzimidazolylmethyl)berberines as Promising Broad-Spectrum Antibacterial Agents
  作者：Hang Sun、Zhen-Zhen Li、Ponmani Jeyakkumar、Zhong-Lin Zang、Bo Fang、Cheng-He Zhou

  DOI：10.1021/acs.jafc.2c03849

  日期：2022.10.5

  produce 13-(benzimidazolylmethyl)berberines (BMB) as potentially broad-spectrum antibacterial agents with the hope of confronting multidrug-resistant bacterial infections in the livestock industry. Some of the newly prepared hybrids showed obvious antibacterial effects against tested strains. Particularly, 13-((1-octyl-benzimidazolyl)methyl)berberine 6f (OBMB-6f) was found to be the most promising compound

  对小檗碱和苯并咪唑进行了新的杂交，以生产 13-(苯并咪唑基甲基)小檗碱 (BMB) 作为潜在的广谱抗菌剂，有望应对畜牧业中的多重耐药细菌感染。一些新制备的杂种对受试菌株表现出明显的抗菌作用。特别是，发现 13-((1-辛基-苯并咪唑基)甲基)小檗碱6f (OBMB- 6f ) 是最有前途的化合物，它不仅具有强活性 (MIC = 0.25–2 μg/mL) 和低细胞毒性，而且还具有快速杀菌能力和对金黄色葡萄球菌和大肠杆菌产生抗药性的低倾向即使在 26 个连续段落之后。此外，OBMB- 6f显示出在低温和高温下防止细菌生物膜形成的能力。机理探索表明，OBMB- 6f可以显着分解细菌膜，显着促进细胞内ROS的产生，并有效地嵌入DNA中。这些结果为 BMB 在畜牧业中对抗多重耐药细菌感染提供了深刻的见解。
• Novel perfluoropolyether derivatives, and lubricants and magnetic recording medium using the same
  申请人：SONY CORPORATION

  公开号：EP0519406A2

  公开（公告）日：1992-12-23

  Novel perfluoropolyether derivatives are described which are obtained from perfluoropolyethers having a carboxyl group at one or both ends and monoamines or diamines. The derivative is useful as a lubricant owing to its significantly improved lubricity. The lubricity is shown under severe high or low temperature and humidity conditions over a long term. The derivative is especially useful as a lubricant for magnetic recording mediums of the coating and metal thin film types.

  本文描述了新型全氟聚醚衍生物，该衍生物由一端或两端带有羧基的全氟聚醚和单胺或二胺制成。这种衍生物的润滑性能显著提高，可用作润滑剂。这种润滑性可在严酷的高温或低温和潮湿条件下长期保持。该衍生物特别适用于涂层型和金属薄膜型磁记录介质的润滑剂。
• Supramolecular Chemistry-Based One-Pot High-Efficiency Separation of Solubilizer-Free Pure Semiconducting Single-Walled Carbon Nanotubes: Molecular Strategy and Mechanism
  作者：Naotoshi Nakashima、Masashi Fukuzawa、Kanako Nishimura、Tsuyohiko Fujigaya、Yuichi Kato、Aleksandar Staykov

  DOI：10.1021/jacs.0c03994

  日期：2020.7.8

  Single-walled carbon nanotubes (SWCNTs) have the potential to revolutionize nanoscale electronics and power sources; however, their low purity and high separation cost limit their use in practical applications. Here we present a supramolecular chemistry-based one-pot, less expensive, scalable, and highly efficient separation of a solubilizer/adsorbent-free pure semiconducting SWCNT (sc-SWCNT) using flavin/isoalloxazine analogues with different substituents. On the basis of both experimental and computational simulations (DFT study), we have revealed the molecular requirements of the solubilizers as well as provided a possible mechanism for such a highly efficient selective sc-SWCNT separation. The present sorting method is very simple (one-pot) and gives a promising sc-SWCNT separation methodology. Thus, the study provides insight for the molecular design of an sc-SWCNT solubilizer with a high (n,m)-chiral selectivity, which benefits many areas including semiconducting nanoelectronics, thermoelectric, bio and energy materials, and devices using solubilizer-free very pure sc-SWCNTs.
• Magnetic recording media using perfluoropolyether derivatives as lubricants
  申请人：SONY CORPORATION

  公开号：EP0519406B1

  公开（公告）日：2000-10-25