(-)-6-bromo-2,2'-di(t-butyldimethylsiloxy)-3,3'-dimethylbinaphthyl | 147749-82-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (-)-6-bromo-2,2'-di(t-butyldimethylsiloxy)-3,3'-dimethylbinaphthyl
• CAS: 147749-82-4
• 化学式: C₃₄H₄₅BrO₂Si₂
• 分子量: 621.805
• InChiKey: YGWDYQYMGZRMBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.81
• 重原子数：
  39.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (-)-6-bromo-2,2'-di(t-butyldimethylsiloxy)-3,3'-dimethylbinaphthyl 在 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) 四丁基氟化铵 、 magnesium 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 (-)-2,2'-dihydroxy-3,3'-dimethyl-6-(undec-10-enyl)binaphthyl
  参考文献：
  名称：

  Monofunctional chiral crowns. Part 1

  摘要：

  A siloxane oligomer bearing a chiral crown with high affinity for alpha-amino acids has been synthesised. The host is a modified form of a coronand first prepared by Cram, in which two 1,1'-binaphthol system are linked through the oxygen atoms at the 2,2'-positions to form a 22-membered ring system containing six ether oxygen atoms attached to each other by four ethylene units. This was selectively mono-alkenylated to form an undec-10-en-1-yl derivative, which was bonded to linear siloxanes [HSiMe2O(SiMe2O)nSiMe2H] and [Me3SiO(Me2SiO)x(MeHSiO)ySiMe3] with total chain lengths of ca 4 and 200 Si atoms respectively, via a Pt catalysed hydrosilylation reaction.

  DOI：

  10.1016/s0040-4020(01)86291-8
• 作为产物：
  描述：

  在 咪唑 、 氢溴酸 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 96.0h， 生成 (-)-6-bromo-2,2'-di(t-butyldimethylsiloxy)-3,3'-dimethylbinaphthyl
  参考文献：
  名称：

  Monofunctional chiral crowns. Part 1

  摘要：

  A siloxane oligomer bearing a chiral crown with high affinity for alpha-amino acids has been synthesised. The host is a modified form of a coronand first prepared by Cram, in which two 1,1'-binaphthol system are linked through the oxygen atoms at the 2,2'-positions to form a 22-membered ring system containing six ether oxygen atoms attached to each other by four ethylene units. This was selectively mono-alkenylated to form an undec-10-en-1-yl derivative, which was bonded to linear siloxanes [HSiMe2O(SiMe2O)nSiMe2H] and [Me3SiO(Me2SiO)x(MeHSiO)ySiMe3] with total chain lengths of ca 4 and 200 Si atoms respectively, via a Pt catalysed hydrosilylation reaction.

  DOI：

  10.1016/s0040-4020(01)86291-8