acetic acid (S)-4-bromo-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-ylmethyl ester | 1307782-37-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: acetic acid (S)-4-bromo-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-ylmethyl ester
• CAS: 1307782-37-1
• 化学式: C₃₁H₃₅BrO₅Si
• 分子量: 595.605
• InChiKey: SOWVPTBDWDCTTF-JFINJBMXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.84
• 重原子数：
  38.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  61.83
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  acetic acid (S)-4-bromo-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-ylmethyl ester 在 四氧化锇 、 N-甲基吗啉氧化物 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 、 水 、 丙酮 、 甲苯 为溶剂， 反应 49.0h， 生成
  参考文献：
  名称：

  Asymmetric synthesis of aryl cyclitols based on 1,2,3,4-tetrahydronaphthalene scaffolds

  摘要：

  A series of aryl cyclitols based on a 1,2,3,4-tetrahydronaphthalene scaffold have been synthesized in a stereocontrolled manner. These cyclitols possess four contiguous stereocenters amongst which one is a quaternary stereocenter, which has been constructed by applying enzymatic kinetic resolution reaction. The remaining stereocenters have been created by substrate directed asymmetric dihydroxylation reaction and stereoselective keto-reduction process. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.02.009
• 作为产物：
  描述：

  acetic acid (S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-7-methoxy-1-oxo-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl ester 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氯化碳 为溶剂， 反应 1.0h， 生成 acetic acid (S)-4-bromo-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-ylmethyl ester
  参考文献：
  名称：

  Asymmetric synthesis of aryl cyclitols based on 1,2,3,4-tetrahydronaphthalene scaffolds

  摘要：

  A series of aryl cyclitols based on a 1,2,3,4-tetrahydronaphthalene scaffold have been synthesized in a stereocontrolled manner. These cyclitols possess four contiguous stereocenters amongst which one is a quaternary stereocenter, which has been constructed by applying enzymatic kinetic resolution reaction. The remaining stereocenters have been created by substrate directed asymmetric dihydroxylation reaction and stereoselective keto-reduction process. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.02.009