7-methyl-1,2,4-triazolo<1,5-a>-pyrimidine | 42399-86-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并嘧啶类
• 英文名称: 7-methyl-1,2,4-triazolo<1,5-a>-pyrimidine
• 英文别名: 5-methyl-1,2,4-triazolo{1,5-a}pyrimidine；7-methyl-[1,2,4]triazolo[1,5-a]pyrimidine；7-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin；7-Methyl-s-triazolo<1,5-a>pyrimidin；7-Methyl-s-triazolo<2,3-a>pyrimidin；7-Methyl-[1,2,4]triazolo[1,5-a]pyrimidine
• CAS: 42399-86-0
• 化学式: C₆H₆N₄
• 分子量: 134.14
• InChiKey: IINPDYKXLROXTC-UHFFFAOYSA-N

物化性质

• 熔点：
  136-138 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• 密度：
  1.39±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  43.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-methyl-1,2,4-triazolo<1,5-a>-pyrimidine 、 copper(II) thiocyanate 以 甲醇 为溶剂， 生成 bis(thiocyanato-N)bis(5-methyl{1,2,4}triazolo{1,5-a}pyrimidine-N3)copper(II)
  参考文献：
  名称：

  Structures and properties of bis(thiocyanato-N)bis(6-methyl[1,2,4]triazolo[1,a]pyrimidine-N3)copper(II), a distorted tetrahedral copper(II) thiocyanate compound, and bis(thiocyanato-N)bis(5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-N3)copper(II), a polynuclear pseudo-layered system

  摘要：

  DOI：

  10.1016/s0277-5387(00)81259-0
• 作为产物：
  描述：

  4-methyl-2-nitroamino-pyrimidine-5-carboxylic acid ethyl ester 在 sodium hydroxide 、 水 、 一水合肼 作用下， 生成 7-methyl-1,2,4-triazolo<1,5-a>-pyrimidine
  参考文献：
  名称：

  Sirakawa, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1959, vol. 79, p. 1487,1491

  摘要：

  DOI：

文献信息

• [EN] HERBICIDAL COMPOUNDS<br/>[FR] COMPOSÉS HERBICIDES
  申请人：SYNGENTA CROP PROTECTION AG

  公开号：WO2021058595A1

  公开（公告）日：2021-04-01

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是除草剂时有用。
• NOVEL FAP INHIBITORS
  申请人：UNIVERSITEIT ANTWERPEN

  公开号：US20140357650A1

  公开（公告）日：2014-12-04

  The present invention relates to novel inhibitors having high selectivity and specificity for FAP (fibroblast activation protein). Said inhibitors are useful as a human and/or veterinary medicine, in particular for the treatment and/or prevention of FAP-related disorders such as but not limited to proliferative disorders.

  本发明涉及具有高选择性和特异性的新型抑制剂，用于FAP（成纤维细胞激活蛋白）。所述抑制剂可用作人类和/或兽医药物，特别用于治疗和/或预防与FAP相关的疾病，如但不限于增殖性疾病。
• 5,6-Cycloalkyl-7-Aminotriazolopyrimidines, their Preparation and their Use for Controlling Harmful Fungi, and Compositions Comprising these Compounds
  申请人：Tormo i Blasco Jordi

  公开号：US20080058208A1

  公开（公告）日：2008-03-06

  The invention relates to 5,6-cycloalkyl-7-aminotriazolopyrimidines of formula (I), where X=alkylene or alkenylene, whereby the carbon chain can be interrupted by one or two heteroatoms selected from S, O or NR 1 , R 1 ═H, alkyl or C(═O)alkyl, L=halogen, cyano, nitro, alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkinyl or NR 2 R 3 ; R 2 ,R 3 =each one of the groups given for R 1 and m=a whole number from 0 to 5, whereby the aliphatic groups can be substituted by one to three of the following groups: halogen, cyano, nitro, hydroxy, alkoxy, alkylthio, or NR a R b , where R a , R b ═H or alkyl in which the carbon chains can be halogenated. The invention further relates to methods for production of said compounds, agents comprising the same and use thereof for the prevention of fungal pests harmful to plants.

  本发明涉及式(I)的5,6-环烷基-7-氨基三唑嘧啶，其中X=烷基或烯基，碳链可以被S、O或NR1中选择的一个或两个杂原子中断，其中R1=H、烷基或C(═O)烷基，L=卤素、氰基、硝基、烷基、卤代烷基、烷氧基、卤代烷氧基、烯基、炔基或NR2R3；R2、R3=给定为R1的各个基团之一；m=0到5的整数，其中脂肪族基团可以被以下一到三个基团之一取代：卤素、氰基、硝基、羟基、烷氧基、烷基硫醚或NRaRb，其中Ra、Rb=可以是H或碳链可以卤代的烷基。本发明还涉及所述化合物的制备方法、包含它们的制剂以及它们在预防对植物有害的真菌害虫方面的用途。
• PIPERIDINE DERIVATIVES AS JAK3 INHIBITORS
  申请人：Babu Yarlagadda S.

  公开号：US20110165183A1

  公开（公告）日：2011-07-07

  The invention provides a compound of formula (I): wherein W is a bicyclic heteroaromatic group; or a salt thereof. The compounds and salts thereof have beneficial therapeutic properties (e.g. immunosuppressant properties).

  该发明提供了一个式子为(I)的化合物：其中W是一个双环杂芳基团；或其盐。该化合物及其盐具有有益的治疗特性（例如免疫抑制特性）。
• Heterocyclic compounds that inhibit the kinase activity of Mnk useful for treating various cancers
  申请人：eFFECTOR Therapeutics, Inc.

  公开号：US10000487B2

  公开（公告）日：2018-06-19

  The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula IA or Formula IB, as well as stereoisomers, tautomers or pharmaceutically acceptable salts thereof. For Formula IA and Formula IB compounds A1, A2, A3, A4, W1, W2, Y, X, R1, R2, R3, R4a, R4b, R5a, R5b, R6, R7, R8, R9, R9a, R9b, R10 and subscript n are as defined in the specification. The inventive Formula IA and Formula IB compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

  本发明提供了符合式 IA 或式 IB 的化合物及其立体异构体、同系物或药学上可接受的盐的合成、药学上可接受的制剂和用途。 对于式 IA 和式 IB 化合物 A1、A2、A3、A4、W1、W2、Y、X、R1、R2、R3、R4a、R4b、R5a、R5b、R6、R7、R8、R9、R9a、R9b、R10 和下标 n 如说明书中所定义。本发明的式IA和式IB化合物是Mnk的抑制剂，可用于各种治疗应用，包括但不限于炎症和各种癌症的治疗。