Optimization of triarylimidazoles for Tie2: Influence of conformation on potency
摘要:
In an effort to understand the effect of N-alkylation of triarylimidazoles on Tie2 inhibition, ortho-substituted C-2 aryl analogs were synthesized to investigate the effect of different torsion angles on potency. This exercise resulted in the identification of a potent and selective tetrasubstituted imidazole that was efficacious in an animal model of angiogenesis. (c) 2007 Elsevier Ltd. All rights reserved.
There is provided compounds of formula I,
wherein R
1
to R
7
have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS
申请人:AstraZeneca AB
公开号:EP2049484A1
公开(公告)日:2009-04-22
Isoindoline Derivatives For The Treatment Of Arrhythmias
申请人:Bjore Annika
公开号:US20100298392A1
公开(公告)日:2010-11-25
There is provided compounds of formula I, wherein R
1
to R
7
have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
US9550775B2
申请人:——
公开号:US9550775B2
公开(公告)日:2017-01-24
[EN] ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS<br/>[FR] DÉRIVÉS D'ISOINDOLINE DANS LE TRAITEMENT DES ARYTHMIES
申请人:ASTRAZENECA AB
公开号:WO2008008022A1
公开(公告)日:2008-01-17
[EN] There is provided compounds of formula I, wherein R1 to R7 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias. [FR] La présente invention concerne des composés de formule I, où R1 à R7 ont les valeurs données dans la description, qui peuvent être employés dans le traitement prophylactique et thérapeutique des arythmies, en particulier des arythmies auriculaires et ventriculaires.