3-hydroxy-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide | 148965-14-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-hydroxy-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide
• 英文别名: 3-hydroxy-5,6,7,8-tetrahydro-[2]naphthoic acid anilide；3-Hydroxy-5,6,7,8-tetrahydro-[2]naphthoesaeure-anilid；Tetralol-(2)-carbonsaeure-(3)-anilid
• CAS: 148965-14-4
• 化学式: C₁₇H₁₇NO₂
• 分子量: 267.327
• InChiKey: CAKHZEARIZQKMN-UHFFFAOYSA-N

物化性质

• 沸点：
  400.4±45.0 °C(Predicted)
• 密度：
  1.251±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.52
• 重原子数：
  20.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  49.33
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  5,6,7,8-四氢-2-萘酚 在 potassium carbonate 、 甲苯 、 三氯化磷 作用下， 160.0~170.0 ℃ 、1.01 MPa 条件下， 生成 3-hydroxy-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide
  参考文献：
  名称：

  Schroeter, Justus Liebigs Annalen der Chemie, 1922, vol. 426, p. 132

  摘要：

  DOI：

文献信息

• Regioselective and Chemoselective Reduction of Naphthols Using Hydrosilane in Methanol: Synthesis of the 5,6,7,8-Tetrahydronaphthol Core
  作者：Yuan He、Jinghua Tang、Meiming Luo、Xiaoming Zeng

  DOI：10.1021/acs.orglett.8b01273

  日期：2018.7.20

  A regioselective and chemoselective method for catalytic synthesis of biologically interesting 5,6,7,8-tetrahydronaphthols by reduction of naphthols was described. The side aromatic hydrocarbons in naphthols were site-selectively reduced, using hydrosilanes in methanol, allowing for retaining functional phenol scaffolds intact. It presents a rare example of using low-cost and air-stable hydrosilane

  描述了一种区域选择性和化学选择性方法，用于通过还原萘酚催化合成生物学上令人感兴趣的5,6,7,8-四氢萘酚。使用甲醇中的氢硅烷可选择性地还原萘酚中的侧链芳香烃，从而使功能性酚骨架保持完整。它提供了一个罕见的示例，该示例使用低成本且空气稳定的氢化硅烷在温和条件下催化还原未活化的芳烃。该反应是可扩展的，并且以高选择性进行，而没有形成1,2,3,4-四氢萘酚副产物，其可耐受敏感的官能团，例如溴化物，氯化物，氟化物，酮，酯和酰胺。
• Hopper; MacGregor; Wilson, Journal of the Society of Dyers and Colourists, 1939, vol. 55, p. 449,451
  作者：Hopper、MacGregor、Wilson

  DOI：——

  日期：——
• DE725279
  申请人：——

  公开号：——

  公开（公告）日：——
• Prevalence of Undernutrition and Vitamin A Deficiency in the Dogon Region, Mali
  作者：Jean-François Schémann、Albert A. Banou、Ando Guindo、Vincent Joret、Lamine Traore、Denis Malvy

  DOI：10.1080/07315724.2002.10719239

  日期：2002.10

  Objectives: A representative sample of 1510 preschool children living in the Bandiagra circle (Mopti Region, Mali) was examined between March and April 1997 to determine the level of vitamin A deficiency.Methods: Using a randomized two level cluster sampling, 20 clusters of 75 children aged six months to six years were selected for evaluating xerophthalmia (XN night blindness and/or X1B Bitot spot). Concurrently stature and weight were determined. A semiquantitative seven-day dietary questionnaire was applied to the mothers of 484 infants to assess consumption of vitamin A rich foodstuffs. The prevalence of biochemical deficiency was attested using the Modified Relative Dose Response test (MRDR) on a sub-sample of 192.Results: Of the studied children, 4.3% (95% Confidence interval [Cl]: 3.2-5.3) reported night blindness and 2% (95% Cl: 1.3-2.7) bad Bitot spots. Prevalence of xerophthalmia attested by at least one of these signs was 5.4% (95% Cl: 4.2-6.5). The prevalence reached 10.5% at three years of age. The MRDR test proved abnormal in 77.1% of the subjects (95% Cl: 70.3-82.7). Serum retinol was lower than 0.35 mumol/L, in 43.8% (95.6% Cl: 36.9-51.3) and less than 0.70 mumol/L in 92.7% of the children (95% Cl: 87.8-95.8). Weekly consumption of vitamin A rich food was rare: 75.8% had not eaten any animal vitamin A rich food, and 22.1% had consumed less than seven times a vitamin A rich food of either vegetable or animal origin.Conclusions: These data define vitamin A deficiency as a severe public health problem in the Bandiagara area of Mali.
• Production of partially hydrogenated hydroxy compounds
  申请人：GEN ANILINE WORKS INC

  公开号：US02132193A1

  公开（公告）日：1938-10-04