(4-(diethylamino)-2-hydroxyphenyl)(p-tolyl)methanone | 1061330-70-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-(diethylamino)-2-hydroxyphenyl)(p-tolyl)methanone
• CAS: 1061330-70-8
• 化学式: C₁₈H₂₁NO₂
• 分子量: 283.37
• InChiKey: XORKJVFXAZIYHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.78
• 重原子数：
  21.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  40.54
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (4-(diethylamino)-2-hydroxyphenyl)(p-tolyl)methanone 、 间苯二酚 在 甲烷磺酸 作用下， 反应 2.5h， 以43%的产率得到
  参考文献：
  名称：

  Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties

  摘要：

  We have demonstrated the synthesis of regioisomerically pure unsymmetrical xanthene derivatives consisting of three units which can be independently modified to control their physical properties. The photochemical properties of the synthetic unsymmetrical xanthene derivatives were investigated in solution by UV-vis absorption and fluorescence measurements, and their cell imaging properties were examined by confocal laser-scanning microscopy. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.065
• 作为产物：
  描述：

  (4-(diethylamino)-2-methoxyphenyl)(p-tolyl)methanone 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以61%的产率得到(4-(diethylamino)-2-hydroxyphenyl)(p-tolyl)methanone
  参考文献：
  名称：

  Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties

  摘要：

  We have demonstrated the synthesis of regioisomerically pure unsymmetrical xanthene derivatives consisting of three units which can be independently modified to control their physical properties. The photochemical properties of the synthetic unsymmetrical xanthene derivatives were investigated in solution by UV-vis absorption and fluorescence measurements, and their cell imaging properties were examined by confocal laser-scanning microscopy. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.065

文献信息

• Iridium- and rhodium-catalyzed C–H activation and formyl arylation of benzaldehydes under chelation-assistance
  作者：Xifa Yang、He Wang、Xukai Zhou、Xingwei Li

  DOI：10.1039/c6ob00825a

  日期：——

  Mild and efficient synthesis of benzophenones via Ir(iii)- and Rh(iii)-catalyzed, directing group-assisted formyl C–H arylation of benzaldehydes has been achieved using diaryliodonium salts, in which Rh(iii) and Ir(iii) catalysts exhibited a complementary substrate scope.

  通过使用二芳基碘鎓盐，已经实现了对苯甲醛进行Rh(iii)和Ir(iii)催化、取向基辅助的甲酰C-H芳基化的温和高效合成苯甲酮，其中Rh(iii)和Ir(iii)催化剂展示出互补的底物范围。