(S)-2-amino-1,1-di(2-n-butoxy-5-t-butylphenyl)propanol | 54464-77-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-2-amino-1,1-di(2-n-butoxy-5-t-butylphenyl)propanol
• 英文别名: (2S)-2-amino-1,1-di(5-tert-butyl-2-n-butoxyphenyl)-1-propanol；(2S)-2-amino-1,1-bis(2-butoxy-5-tert-butylphenyl)propan-1-ol
• CAS: 54464-77-6
• 化学式: C₃₁H₄₉NO₃
• 分子量: 483.735
• InChiKey: DZOULYFAEJFIDM-QFIPXVFZSA-N

物化性质

• 沸点：
  596.6±50.0 °C(Predicted)
• 密度：
  0.998±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  35
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-硝基水杨醛 、 (S)-2-amino-1,1-di(2-n-butoxy-5-t-butylphenyl)propanol 以 乙醇 为溶剂， 反应 6.0h， 生成 (S)-N-(5-nitro-salicylidene)-2-amino-1,1-di-(5-tert-butyl-2-butoxy-phenyl)-propan-1-ol
  参考文献：
  名称：

  Asymmetric Cyclopropanation of Styrene Catalyzed by Cu–(Chiral Schiff-Base) Complexes

  摘要：

  Asymmetric cyclopropanation of olefins was carried out with chiral copper-Schiff base complexes derived from copper acetate monohydrate, substituted salicylaldehydes and a chiral amino alcohol. Substituents on salicylaldehyde framework demonstrate a significant effect on the steroselectivities. Those with electron-withdrawing properties enhance the selectivities, whereas bulky sustituents in ortho position to the phenol hydroxy group decrease the selectivities. An ee of more than 98% was achieved for the reaction of styrene with diazoacetate. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00623-2
• 作为产物：
  描述：

  2-溴-1-丁氧基-4-叔丁基苯 、 L-丙氨酸甲酯盐酸盐 在 magnesium 作用下， 以 乙二醇二甲醚 为溶剂， 以70%的产率得到(S)-2-amino-1,1-di(2-n-butoxy-5-t-butylphenyl)propanol
  参考文献：
  名称：

  Asymmetric Cyclopropanation of Styrene Catalyzed by Cu–(Chiral Schiff-Base) Complexes

  摘要：

  Asymmetric cyclopropanation of olefins was carried out with chiral copper-Schiff base complexes derived from copper acetate monohydrate, substituted salicylaldehydes and a chiral amino alcohol. Substituents on salicylaldehyde framework demonstrate a significant effect on the steroselectivities. Those with electron-withdrawing properties enhance the selectivities, whereas bulky sustituents in ortho position to the phenol hydroxy group decrease the selectivities. An ee of more than 98% was achieved for the reaction of styrene with diazoacetate. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00623-2

文献信息

• METHOD FOR PRODUCING ASYMMETRIC COPPER COMPLEX CRYSTAL
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2078710A1

  公开（公告）日：2009-07-15

  A method of producing an asymmetric copper complex crystal comprising reacting an optically active salicylidene amino alcohol compound with a copper compound, then, performing a crystallization treatment in the presence of an alcohol solvent.

  一种生产不对称铜络合物晶体的方法，包括使光学活性水杨基氨基醇化合物与铜化合物反应，然后在醇溶剂存在下进行结晶处理。
• EP2078710
  申请人：——

  公开号：——

  公开（公告）日：——
• PRODUCTION METHOD OF ASYMMETRIC COPPER COMPLEX CRYSTAL
  申请人：Hirata Norihiko

  公开号：US20100094036A1

  公开（公告）日：2010-04-15

  A method of producing an asymmetric copper complex crystal comprising reacting an optically active salicylidene amino alcohol compound with a copper compound, then, performing a crystallization treatment in the presence of an alcohol solvent.
• US8153830B2
  申请人：——

  公开号：US8153830B2

  公开（公告）日：2012-04-10