4-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)benzamide | 55635-96-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)benzamide
• 英文别名: 4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzamide
• CAS: 55635-96-6
• 化学式: C₁₀H₇Cl₂N₅O
• 分子量: 284.104
• InChiKey: KSODUXFVELIGJU-UHFFFAOYSA-N

物化性质

• 熔点：
  >250 °C
• 沸点：
  564.8±52.0 °C(Predicted)
• 密度：
  1.598±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  93.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-甲氧基苄胺 、 异丙胺 、 4-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)benzamide 生成 4-[[4-[(4-Methoxyphenyl)methylamino]-6-(propan-2-ylamino)-1,3,5-triazin-2-yl]amino]benzamide
  参考文献：
  名称：

  Facilitated Forward Chemical Genetics Using a Tagged Triazine Library and Zebrafish Embryo Screening

  摘要：

  An improved forward chemical genetics approach was successfully demonstrated using a tagged library concept. A small-molecule triazine library with linkers was used to screen for brain/eye developmental phenotypes in a zebrafish embryo system. This approach enabled the rapid isolation of the target proteins by facile affinity matrix preparation and elucidated the first small-molecule inhibitors for several ribosomal accessory proteins or their complex as the target.

  DOI：

  10.1021/ja035334d
• 作为产物：
  描述：

  三聚氯氰 、 对氨基苯甲酰胺 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 4-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)benzamide
  参考文献：
  名称：

  Facilitated Forward Chemical Genetics Using a Tagged Triazine Library and Zebrafish Embryo Screening

  摘要：

  An improved forward chemical genetics approach was successfully demonstrated using a tagged library concept. A small-molecule triazine library with linkers was used to screen for brain/eye developmental phenotypes in a zebrafish embryo system. This approach enabled the rapid isolation of the target proteins by facile affinity matrix preparation and elucidated the first small-molecule inhibitors for several ribosomal accessory proteins or their complex as the target.

  DOI：

  10.1021/ja035334d

文献信息

• [EN] AFFINITY ADSORBENTS FOR IMMUNOGLOBULINS<br/>[FR] ADSORBANTS A AFFINITE POUR IMMUNOGLOBULINES
  申请人：UNIV CAMBRIDGE TECH

  公开号：WO2004035199A1

  公开（公告）日：2004-04-29

  Use of a compound of formula (I) wherein R1 and R2 are the same or different and are each optionally substituted alkyl or aryl; and R3 is a solid support optionally attached via a spacer; for the affinity binding of an immunoglobulin or fragment thereof.