(E)-5-(4-methylstyryl)-2,2'-bithiophene | 1312948-76-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 双噻吩和低聚噻吩
• 英文名称: (E)-5-(4-methylstyryl)-2,2'-bithiophene
• 英文别名: 2-[(E)-2-(4-methylphenyl)ethenyl]-5-thiophen-2-ylthiophene
• CAS: 1312948-76-7
• 化学式: C₁₇H₁₄S₂
• 分子量: 282.43
• InChiKey: RUAFGPTYAQIUFV-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-甲基氯苄 在 sodium methylate 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 6.0h， 生成 (E)-5-(4-methylstyryl)-2,2'-bithiophene
  参考文献：
  名称：

  Novel (E)-5-styryl-2,2′-bithiophene derivatives as ligands for β-amyloid plaques

  摘要：

  In continuation of our investigation on the bithiophene structure as potential beta-amyloid probes, a series of (E)-5-styryl-2,2'-bithiophene (SBTP) derivatives was designed and synthesized. In vitro binding showed that all of them displayed high binding affinities to A beta(1-42) aggregates (K(i) = 0.10-41.05 nM). Moreover, two radio-iodinated probes, [(125)I]-(E)-5-(4-iodostyryl)-2,2'-bithiophene ([(125)I]8) and [(125)I]-(E)-5-iodo-5'-(4-methoxystyryl)-2,2'-bithiophene ([(125)I]31) were prepared. Both of them displayed specific labeling of A beta plaques in the brain sections of AD model mice with low background. In vivo biodistribution in normal mice indicated that [(125)I]8 exhibited high initial brain uptake (2.11% ID/g at 2 min) and rapid clearance (0.41% ID/g at 30 min). These preliminary results suggest that SBTP derivatives may be served as novel beta-amyloid imaging probes. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.04.015

文献信息

• QUINOXALINE-CONTAINING COMPOUNDS AND POLYMERS THEREOF
  申请人：HORIBA Koji

  公开号：US20080306239A1

  公开（公告）日：2008-12-11

  There is provided a quinoxaline-containing compound represented by the following formula (I); wherein Ar 1 represents a substituted or unsubstituted monovalent aromatic group; and R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group.

  提供一种含有喹啉基的化合物，其化学式如下（I）；其中Ar1代表一个取代或未取代的一价芳香基团；而R1代表氢原子、取代或未取代的烷基团、取代或未取代的芳基团，或取代或未取代的芳基烷基团。
• Novel thiophene-containing compound and thiophene-containing compound polymer, organic electroluminescent device, production method thereof, and image display medium
  申请人：Ohba Yoshihiro

  公开号：US20070252519A1

  公开（公告）日：2007-11-01

  Provided are a thiophene-containing compound represented by the following formula (X-1), and an organic electroluminescent device that includes a pair of electrodes and an organic compound layer disposed therebetween. The organic compound layer includes a charge-transporting polyester having a repeating structure containing at least one structure selected from the structures represented by the following formulae (I-1) and (I-2) as its partial structure. In formula (X-1), Ar 1 represents a substituted or unsubstituted monovalent aromatic group; and R 1 to R 4 each independently represent a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group; and n′ is an integer of 1 to 5.
• US7659410B2
  申请人：——

  公开号：US7659410B2

  公开（公告）日：2010-02-09
• US7902382B2
  申请人：——

  公开号：US7902382B2

  公开（公告）日：2011-03-08
• US7910748B2
  申请人：——

  公开号：US7910748B2

  公开（公告）日：2011-03-22