(2-aminophenyl)triphenylphosphonium chloride | 124843-09-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-aminophenyl)triphenylphosphonium chloride
• 英文别名: (2-Aminophenyl)-triphenylphosphanium;chloride
• CAS: 124843-09-0
• 化学式: C₂₄H₂₁NP*Cl
• 分子量: 389.864
• InChiKey: BOQPXMXXFAFOFN-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.89
• 重原子数：
  27.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.02
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (2-aminophenyl)triphenylphosphonium chloride 以 四氢呋喃 为溶剂， 生成 2-(二苯基膦)苯胺
  参考文献：
  名称：

  Synthesis and biological evaluation of vanadium complexes as novel anti-tumor agents

  摘要：

  A class of vanadium complexes were prepared and investigated for their antiproliferative effects by MTT assay. The structure-activity relationship was extensively studied through the ligand variation. The results showed that the synthetic vanadium complexes demonstrated moderate to good antiproliferative activities against the four cancer cell lines including MGC803, EC109, MCF7 and HepG2, respectively. Of note was that most of the complexes showed preferential growth inhibitory activity to some degree toward gastric cancer line MGC803. Among them, complex 19 exhibited the most and broad-spectrum proliferative inhibition against the tested cell lines. In addition, mechanism studies illustrated that complex 19 could prevent the colony formation, migration and EMT process, as well as induce apoptosis of MGC803 cells. Furthermore, Western blot experiments revealed that the expression of apoptosis-related proteins changed, including up-regulation of Bax, PARP and caspase-3/9, as well as down-regulation of Bcl-2.

  DOI：

  10.1016/j.ejmech.2019.04.073
• 作为产物：
  描述：

  邻氯苯胺 、 三苯基膦 在 nickel dichloride 作用下， 反应 4.0h， 以57%的产率得到(2-aminophenyl)triphenylphosphonium chloride
  参考文献：
  名称：

  Cooper, Mervyn K.; Downes, J. Michael; Duckworth, Paul A., Australian Journal of Chemistry, 1992, vol. 45, # 3, p. 595 - 609

  摘要：

  DOI：

文献信息

• Synthesis, structure, and properties of new phosphorus Schiff bases
  作者：L. D. Popov、S. A. Borodkin、I. N. Shcherbakov、Yu. N. Tkachenko、V. A. Kogan

  DOI：10.1134/s1070363208040099

  日期：2008.4

  A series of new Schiff bases has been synthesized on the basis of (2-aminophenyl)triphenyl-phosphonium chloride and substituted salicylaldehydes. The structure of the prepared compounds has been established by means of IR, UV, and H-1 NMR spectroscopy, as well as DFT B3LYP/6-31G(d,p) quantum-chemical simulation. The possible tautomerism and certain properties of the azomethines, including complex formation, have been studied.
• Cooper, Mervyn K.; Downes, J. Michael; Duckworth, Paul A., Australian Journal of Chemistry, 1992, vol. 45, p. 595 - 610
  作者：Cooper, Mervyn K.、Downes, J. Michael、Duckworth, Paul A.、Tiekink, Edward R. T.

  DOI：——

  日期：——
• Synthesis and Resolution of Quinazolinone Atropisomeric Phosphine Ligands^,
  作者：Xuedong Dai、Audrey Wong、Scott C. Virgil

  DOI：10.1021/jo972105z

  日期：1998.4.1

  The syntheses of 2-methyl-3-[2'-(diphenylphosphino)phenyl]-4(3H)-quinazolinone (MPQ, 1a) and methyl-substituted analogues were achieved in good yield by coupling N-acetylanthranilic acid with the corresponding phosphinoanilines. Resolution of ligand 1b was achieved using (-)-di-mu-chlorobis[(S)-dimethyl-( 1-phenylethyl)aminato-C-2,N]dipalladium(II) (5). The resulting crystalline complex (S,R)-6 served to unambiguously assign the absolute configuration of antipode (R)-(-)-1b. A practical resolution of this series of ligands 1a-c was accomplished using the (benzenesulfonyl)hydrazone derivative of camphorsulfonic acid (7) as a resolving agent.
• Synthesis, structure, and properties of a new phosphorus-containing Schiff’s base, a derivative of pyrazole-5-one
  作者：L. D. Popov、S. A. Borodkin、I. N. Scherbakov、Yu. N. Tkachenko、G. G. Aleksandrov、S. S. Beloborodov、A. A. Zubenko、V. A. Kogan、O. V. Maevskii

  DOI：10.1134/s107036321307013x

  日期：2013.7

  A new Schiff's base and its salt have been prepared from 2-aminophenyl(triphenyl)phosphonium chloride and 5-hydroxy-3-methyl-1-phenyl-4-formylpyrazole. The products structures have been proved by IR, H-1 NMR, and UV spectroscopy, mass spectrometry, X-ray diffraction analysis, and quantum-chemical modeling. Possible tautomerism and some properties of the products have been studied.