(S)-(2-fluorophenyl)-4-isopropyl-4,5-dihydrothiazole | 790713-91-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-(2-fluorophenyl)-4-isopropyl-4,5-dihydrothiazole
• CAS: 790713-91-6
• 化学式: C₁₂H₁₄FNS
• 分子量: 223.314
• InChiKey: BRDLJKBXVLWZSH-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.34
• 重原子数：
  15.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  12.36
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (S)-(2-fluorophenyl)-4-isopropyl-4,5-dihydrothiazole 、 potassium diphenylphosphine 以 四氢呋喃 为溶剂， 反应 0.33h， 以82%的产率得到(S)-(2-diphenylphosphinophenyl)-4-isopropyl-4,5-dihydrothiazole
  参考文献：
  名称：

  Chiral thiazoline ligands: application in Pd-catalysed allylic substitution

  摘要：

  A series of thiazoline ligands, analogues of well-known oxazolines, easily prepared from chiral aminoalcohols, and appropriate dithioesters, was tested in the Pd-catalysed allylic substitution. A systematic comparison with the corresponding oxazolines (using literature data or our own tests) has been made for each case. Some important differences (between their catalytic activity and enantioselectivity) were noted for the two types of ligands, especially in the case of bis(thiazolines) and bis(oxazolines). (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.07.048
• 作为产物：
  描述：

  2-Fluoro-N-((S)-1-hydroxymethyl-2-methyl-propyl)-thiobenzamide 在 甲基磺酰氯 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以96%的产率得到(S)-(2-fluorophenyl)-4-isopropyl-4,5-dihydrothiazole
  参考文献：
  名称：

  Chiral thiazoline ligands: application in Pd-catalysed allylic substitution

  摘要：

  A series of thiazoline ligands, analogues of well-known oxazolines, easily prepared from chiral aminoalcohols, and appropriate dithioesters, was tested in the Pd-catalysed allylic substitution. A systematic comparison with the corresponding oxazolines (using literature data or our own tests) has been made for each case. Some important differences (between their catalytic activity and enantioselectivity) were noted for the two types of ligands, especially in the case of bis(thiazolines) and bis(oxazolines). (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.07.048