tert-butyl N-[(1S,2R)-1-bromo-3-[tert-butyl(dimethyl)silyl]oxy-1-phenylpropan-2-yl]carbamate | 207122-26-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-[(1S,2R)-1-bromo-3-[tert-butyl(dimethyl)silyl]oxy-1-phenylpropan-2-yl]carbamate
• CAS: 207122-26-7
• 化学式: C₂₀H₃₄BrNO₃Si
• 分子量: 444.484
• InChiKey: CNPUEKBSIGGQFA-SJORKVTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.04
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[(1S,2R)-1-bromo-3-[tert-butyl(dimethyl)silyl]oxy-1-phenylpropan-2-yl]carbamate 在 三(三甲基硅基)硅烷 作用下， 生成 (S)-1-叔丁基二甲基硅氧基-3-苯基丙-2-基氨基甲酸叔丁酯
  参考文献：
  名称：

  Highly regioselective opening of optically active N-Boc-2,3-aziridino alcohol derivatives with metal halides

  摘要：

  Chiral 3-substituted N-Boc-2,3-aziridino alcohols are opened in a regio and stereoselective fashion by MgBr2; the obtained 3-bromo derivatives can be reduced and deprotected under mild conditions to the corresponding 1,2-amino alcohols. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00204-4
• 作为产物：
  描述：

  tert-butyl (2S,3S)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-3-phenylaziridine-1-carboxylate 在 magnesium bromide 作用下， 以 乙醚 为溶剂， 反应 4.0h， 生成 tert-butyl N-[(1S,2R)-1-bromo-3-[tert-butyl(dimethyl)silyl]oxy-1-phenylpropan-2-yl]carbamate
  参考文献：
  名称：

  Highly regioselective opening of optically active N-Boc-2,3-aziridino alcohol derivatives with metal halides

  摘要：

  Chiral 3-substituted N-Boc-2,3-aziridino alcohols are opened in a regio and stereoselective fashion by MgBr2; the obtained 3-bromo derivatives can be reduced and deprotected under mild conditions to the corresponding 1,2-amino alcohols. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00204-4

文献信息

• Highly regioselective opening of optically active N-Boc-2,3-aziridino alcohol derivatives with metal halides
  作者：Giuliana Righi、Tiziana Franchini、Carlo Bonini

  DOI：10.1016/s0040-4039(98)00204-4

  日期：1998.4

  Chiral 3-substituted N-Boc-2,3-aziridino alcohols are opened in a regio and stereoselective fashion by MgBr2; the obtained 3-bromo derivatives can be reduced and deprotected under mild conditions to the corresponding 1,2-amino alcohols. (C) 1998 Elsevier Science Ltd. All rights reserved.