2-(3-Methyl-phenyl)-5-pyridin-4-yl-1.3.4-oxadiazol | 93717-83-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-Methyl-phenyl)-5-pyridin-4-yl-1.3.4-oxadiazol
• 英文别名: 5-m-Tolyl-2-pyridyl-(4)-1.3.4-oxadiazol；4-(5-m-tolyl-[1,3,4]oxadiazol-2-yl)-pyridine；4-(m-tolyl-[1,3,4]oxadiazol-2-yl)-pyridine；4-(m-Tolyl-[1,3,4]oxadiazol-2-yl)-pyridin；Cambridge id 5648546；2-(3-methylphenyl)-5-pyridin-4-yl-1,3,4-oxadiazole
• CAS: 93717-83-0
• 化学式: C₁₄H₁₁N₃O
• 分子量: 237.261
• InChiKey: DIQOEJPUEMTAOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-甲基苯甲醛 在 碘苯二乙酸 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 0.12h， 生成 2-(3-Methyl-phenyl)-5-pyridin-4-yl-1.3.4-oxadiazol
  参考文献：
  名称：

  Iodobenzene Diacetate Mediated Solid‐State Synthesis of Heterocyclyl‐1,3,4‐oxadiazoles

  摘要：

  A simple and efficient method has been developed for the oxidation of various heterocyclyl acylhydrazones 3 with iodobenzene diacetate (IBD) to heterocyclyl-1,3,4-oxadiazoles 4 in solid state. The reaction took place at room temperature within few minutes. The products were isolated by simple aqueous work-up in good yields.

  DOI：

  10.1081/scc-120038493

文献信息

• DE1067439
  申请人：——

  公开号：——

  公开（公告）日：——
• Weidinger,H.; Kranz,J., Chemische Berichte, 1963, vol. 96, p. 1049 - 1058
  作者：Weidinger,H.、Kranz,J.

  DOI：——

  日期：——
• Iodobenzene Diacetate Mediated Solid‐State Synthesis of Heterocyclyl‐1,3,4‐oxadiazoles
  作者：V. S. Rao、K. V. G. Chandra Sekhar

  DOI：10.1081/scc-120038493

  日期：2004.12.31

  A simple and efficient method has been developed for the oxidation of various heterocyclyl acylhydrazones 3 with iodobenzene diacetate (IBD) to heterocyclyl-1,3,4-oxadiazoles 4 in solid state. The reaction took place at room temperature within few minutes. The products were isolated by simple aqueous work-up in good yields.