N¹-(metylotio-tiokarbonylo)-pirazynoamidrazon | 154192-37-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N¹-(metylotio-tiokarbonylo)-pirazynoamidrazon
• 英文别名: methyl N-[(Z)-[amino(pyrazin-2-yl)methylidene]amino]carbamodithioate
• CAS: 154192-37-7
• 化学式: C₇H₉N₅S₂
• 分子量: 227.314
• InChiKey: BNUIXLRSVXOLAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  134
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N¹-(metylotio-tiokarbonylo)-pirazynoamidrazon 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 4-(2-hydroxyethyl)-5-methylsulfanyl-3-pyrazinyl[1,2,4]triazole
  参考文献：
  名称：

  Reactivity of N ¹-Dithioester Substituted Pyridinand Pyrazincarboxamidrazones

  摘要：

  The N1-dithioester substituted pyridin- and pyrazincarboxamidrazones underwent cyclocondensation to 5-methylsulfanyl-1,3,4-thiadiazole or 1,2,4-triazole derivatives, depending on the reaction conditions. With an excess of secondary amines, pyrazincarboxamidrazone dithioester gave 5-amino-1,3,4-thiadiazoles and with an ethanoloamine a 1,2,4-triazole derivative. Prepared compounds were evaluated as potential tuberculostatic agents, but the minimum inhibitory concentrations values indicated no significant activity.

  DOI：

  10.1080/10426500500270065
• 作为产物：
  描述：

  2-氰基吡嗪 在 sodium 作用下， 以 乙醇 为溶剂， 反应 0.58h， 生成 N¹-(metylotio-tiokarbonylo)-pirazynoamidrazon
  参考文献：
  名称：

  Foks, Henryk; Orlewska, Czeslawa; Janowiec, Mieczyslaw, Acta Poloniae Pharmaceutica, 1992, vol. 49, # 5, p. 47 - 50

  摘要：

  DOI：

文献信息

• Orlewska; Foks; Janowiec, Pharmazie, 1995, vol. 50, # 8, p. 565 - 566
  作者：Orlewska、Foks、Janowiec、Zwolskakwiek

  DOI：——

  日期：——
• Foks, Henryk; Orlewska, Czeslawa; Janowiec, Mieczyslaw, Acta Poloniae Pharmaceutica, 1992, vol. 49, # 5, p. 47 - 50
  作者：Foks, Henryk、Orlewska, Czeslawa、Janowiec, Mieczyslaw

  DOI：——

  日期：——
• Reactivity of <i>N</i> ¹-Dithioester Substituted Pyridinand Pyrazincarboxamidrazones
  作者：Czeslawa Orlewska、Danuta Pancechowska-Ksepko、Henryk Foks、Zofia Zwolska、Ewa Augustynowicz-Kopec

  DOI：10.1080/10426500500270065

  日期：2006.4.1

  The N1-dithioester substituted pyridin- and pyrazincarboxamidrazones underwent cyclocondensation to 5-methylsulfanyl-1,3,4-thiadiazole or 1,2,4-triazole derivatives, depending on the reaction conditions. With an excess of secondary amines, pyrazincarboxamidrazone dithioester gave 5-amino-1,3,4-thiadiazoles and with an ethanoloamine a 1,2,4-triazole derivative. Prepared compounds were evaluated as potential tuberculostatic agents, but the minimum inhibitory concentrations values indicated no significant activity.