Methyl-[2-phenyl-eth-(E)-ylidene]-amine | 384828-07-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl-[2-phenyl-eth-(E)-ylidene]-amine
• CAS: 384828-07-3
• 化学式: C₉H₁₁N
• 分子量: 133.193
• InChiKey: GDCHZPPWHWLRPX-CSKARUKUSA-N

物化性质

• 沸点：
  233.7±23.0 °C(Predicted)
• 密度：
  0.87±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.93
• 重原子数：
  10.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  12.36
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  N-乙酰基-D-亮氨酸 、 Methyl-[2-phenyl-eth-(E)-ylidene]-amine 、 E,Z-3-(2-isocyanoethen)-indole 以 甲醇 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  One-pot synthesis and biological evaluation of aspergillamides and analogues

  摘要：

  A one-pot total synthesis of aspergillamide and analogues by a solution phase Ugi multi component reaction (MCR) is described. The reaction is easily performed in 96-well plates and offers a facile access to diverse aspergillamide analogue compound libraries. The antibiotic and cytotoxic activity of these compounds is measured. Several of them are more potent than the natural product. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00305-x
• 作为产物：
  描述：

  苯乙醛 、 甲胺 以 二氯甲烷 为溶剂， 生成 Methyl-[2-phenyl-eth-(E)-ylidene]-amine
  参考文献：
  名称：

  One-pot synthesis and biological evaluation of aspergillamides and analogues

  摘要：

  A one-pot total synthesis of aspergillamide and analogues by a solution phase Ugi multi component reaction (MCR) is described. The reaction is easily performed in 96-well plates and offers a facile access to diverse aspergillamide analogue compound libraries. The antibiotic and cytotoxic activity of these compounds is measured. Several of them are more potent than the natural product. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00305-x

文献信息

• Chelation directed C—H activation reactions catalyzed by solid-supported palladium(II) catalysts
  申请人：VIRGINIA COMMONWEALTH UNIVERSITY

  公开号：US10000453B2

  公开（公告）日：2018-06-19

  Chelation directed C—H activation reactions that are catalyzed by Pd(11) on Multi-Walled Carbon Nanotubes (MWCNT), Single-Walled Carbon Nanotubes (SWCNT), or graphene are provided. The reactions are used to directly and regioselectively or regiospecifically functionalize specific C—H bonds, e.g. to build complexity into small molecules. Features and advantages of the present invention will be set forth in the description of invention that follows, and in part will be apparent from the description or may be learned by practice of the invention. The invention will be realized and attained by the compositions and methods particularly pointed out in the written description and claims hereof.

  提供了在多壁碳纳米管 (MWCNT)、单壁碳纳米管 (SWCNT) 或石墨烯上由 Pd(11) 催化的螯合定向 C-H 活化反应。这些反应可用于直接、区域选择性或区域特异性地官能化特定的 C-H 键，例如将复杂性转化为小分子。本发明的特征和优点将在下文的发明描述中阐述，部分特征和优点将从描述中显而易见，或可通过本发明的实践了解到。本发明将通过书面说明和权利要求中特别指出的组合物和方法来实现和达到。
• ADLER B.; BURTZLAFF C.; DUSCHEK C.; OHL J.; SCHMIDT H.; ZECH W., J. PRAKT. CHEM., 1978, 320, NO 6, 904-916
  作者：ADLER B.、 BURTZLAFF C.、 DUSCHEK C.、 OHL J.、 SCHMIDT H.、 ZECH W.

  DOI：——

  日期：——
• ORGANIC ELECTROLUMINESCENCE DEVICE
  申请人：LG Chem, Ltd.

  公开号：EP3214151B1

  公开（公告）日：2020-10-14
• CHELATION DIRECTED C-H ACTIVATION REACTIONS CATALYZED BY SOLID-SUPPORTED PALLADIUM(II) CATALYSTS
  申请人：Virginia Commonwealth University

  公开号：EP3227018B1

  公开（公告）日：2021-06-30
• US8912308B2
  申请人：——

  公开号：US8912308B2

  公开（公告）日：2014-12-16