3,5-Dibromo-4-{2-[hydroxy(3-methylphenyl)methyl]-5-isopropyl-4-methoxy-phenoxy}-phenylacetic acid | 348166-50-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-Dibromo-4-{2-[hydroxy(3-methylphenyl)methyl]-5-isopropyl-4-methoxy-phenoxy}-phenylacetic acid
• 英文别名: 3,5-Dibromo-4-[2-(hydroxy(3-methylphenyl)methyl)-5-isopropyl-4-methoxyphenoxy]-phenylacetic Acid；2-[3,5-dibromo-4-[2-[hydroxy-(3-methylphenyl)methyl]-4-methoxy-5-propan-2-ylphenoxy]phenyl]acetic acid
• CAS: 348166-50-7
• 化学式: C₂₆H₂₆Br₂O₅
• 分子量: 578.297
• InChiKey: KWPBSDSVSAPXRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,5-Dibromo-4-{2-[hydroxy(3-methylphenyl)methyl]-5-isopropyl-4-methoxy-phenoxy}-phenylacetic acid 、 4-{2-[chloro(3-methylphenyl)methyl]-5-isopropyl-4-methoxyphenoxy}3,5-dibromo-phenylacetic acid metyl ester 在 氯化亚砜 作用下， 生成 3,5-Dibromo-4-{2-[(N-{4-methylbenzenesulfonyl}amino)(3-methylphenyl)-methyl]-5-isopropyl-4-methoxyphenoxy}phenylacetic acid
  参考文献：
  名称：

  Compounds active at the glucocorticoid receptor

  摘要：

  这项发明涉及一种新型化合物，它们是肝选择性糖皮质激素受体拮抗剂，涉及制备这种化合物的方法，以及使用这种化合物进行治疗和调节新陈代谢的方法，尤其是降低血糖水平。所提到的化合物是根据式(I)的化合物。

  公开号：

  US20030166725A1
• 作为产物：
  描述：

  (3,5-Dibromo-4-(5-isopropyl-4-methoxy-2-(3-methyl-benzoyl)-phenoxy)-phenyl)-acetic acid 在 sodium tetrahydroborate 、 LiOH 作用下， 以 水 为溶剂， 以77%的产率得到3,5-Dibromo-4-{2-[hydroxy(3-methylphenyl)methyl]-5-isopropyl-4-methoxy-phenoxy}-phenylacetic acid
  参考文献：
  名称：

  Compounds active at the glucocorticoid receptor

  摘要：

  这项发明涉及一种新型化合物，它们是肝选择性糖皮质激素受体拮抗剂，涉及制备这种化合物的方法，以及使用这种化合物进行治疗和调节新陈代谢的方法，尤其是降低血糖水平。所提到的化合物是根据式(I)的化合物。

  公开号：

  US20030166725A1

文献信息

• COMPOUNDS ACTIVE AT THE GLUCOCORTICOID RECEPTOR
  申请人：KARO BIO AB

  公开号：EP1265839A1

  公开（公告）日：2002-12-18
• [EN] COMPOUNDS ACTIVE AT THE GLUCOCORTICOID RECEPTOR<br/>[FR] COMPOSES ACTIFS AU NIVEAU DU RECEPTEUR GLUCOCORTICOIDE
  申请人：KAROBIO AB

  公开号：WO2001047859A1

  公开（公告）日：2001-07-05

  This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in therapy and in the regulation of metabolism, especially lowering blood glucose levels. The compounds referred to are compounds according to the formula (I).
• [EN] COMPOUNDS ACTIVE AT THE GLUCOCORTICOID RECEPTOR III<br/>[FR] COMPOSES AYANT UNE ACTION SUR LE RECEPTEUR GLUCOCORTICOIDE III
  申请人：KAROBIO AB

  公开号：WO2002044120A1

  公开（公告）日：2002-06-06

  This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in therapy and in the regulation of metabolism, especially lowering blood glucose levels. The compounds referred to are compounds according to the formula (I): wherein R1 is selected from: COOH and heteroaryl; R?2 and R3¿ are independently of each other selected from: hydrogen, halogen, and C¿1-6?-alkyl, provided that one of R?2 or R3¿ other than hydrogen; R4 is selected form: C¿1-6?-alkyl, C3-8-alkenyl, and C2-6-alkynyl; R?5¿ is selected form: hydrogen, C¿1-12?-alkyl, C2-6-alkenyl and C2-6-alkynyl; R?6 and R7¿ are independently of each other selected from: aryl, heteroaryl, and C¿3-8?-heterocycloalkyl; or pharmaceutically acceptable salts, stereoisomers or prodrugs thereof.
• Compounds active at the glucocorticoid receptor
  申请人：——

  公开号：US20030166725A1

  公开（公告）日：2003-09-04

  This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in therapy and in the regulation of metabolism, especially lowering blood glucose levels. The compounds referred to are compounds according to the formula (I).

  这项发明涉及一种新型化合物，它们是肝选择性糖皮质激素受体拮抗剂，涉及制备这种化合物的方法，以及使用这种化合物进行治疗和调节新陈代谢的方法，尤其是降低血糖水平。所提到的化合物是根据式(I)的化合物。