2-(1-benzyl-1H-tetrazol-5-yl)-ethylamine | 103392-28-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(1-benzyl-1H-tetrazol-5-yl)-ethylamine
• 英文别名: 2-(1-Benzyl-1H-tetrazol-5-yl)-aethylamin；2-(1-Benzyltetrazol-5-yl)ethanamine
• CAS: 103392-28-5
• 化学式: C₁₀H₁₃N₅
• 分子量: 203.247
• InChiKey: DPRKEZYMDCIQNQ-UHFFFAOYSA-N

物化性质

• 沸点：
  442.8±34.0 °C(Predicted)
• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(1-benzyl-1H-tetrazol-5-yl)-ethylamine 在 palladium on activated charcoal 、 乙醇 作用下， 生成 2-(5-四唑基)乙胺
  参考文献：
  名称：

  Tetrazole Analogs of Amino Acids¹

  摘要：

  DOI：

  10.1021/jo01093a006
• 作为产物：
  描述：

  2-(1-benzyltetrazol-5-yl)-N-tritylethanamine 在 2,2,2-三氟乙醇 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 2-(1-benzyl-1H-tetrazol-5-yl)-ethylamine
  参考文献：
  名称：

  Efficient Syntheses of 5-Aminoalkyl-1H-tetrazoles and of Polyamines Incorporating Tetrazole Rings

  摘要：

  Linear N-omega-tritylated omega-amino th iobenzylam ides and N-alpha,N-omega-ditritylated polyamino mono- or bisthioamides were efficiently converted to the corresponding tetrazole derivatives upon treatment with azidotrimethylsilane under Mitsunobu reaction conditions.

  DOI：

  10.1021/ol0477069

文献信息

• Synthesis and antioxidative/anti-inflammatory activity of novel fullerene–polyamine conjugates
  作者：George E. Magoulas、Thomas Garnelis、Constantinos M. Athanassopoulos、Dionissios Papaioannou、George Mattheolabakis、Konstantinos Avgoustakis、Dimitra Hadjipavlou-Litina

  DOI：10.1016/j.tet.2012.06.066

  日期：2012.9

  (E)-4-(Fullerenopyrrolidin-1-yl)-3-methylbut-2-enoic acid and its corresponding succinimidyl ester, readily obtained through Prato-type modification of C-60, were used for the selective N-acylation of polyamines. The thus obtained conjugates were evaluated for their antioxidative and anti-inflammatory activity and their cytotoxicity was determined. Members of this family of compounds showed interesting anti-lipid peroxidation, anti-lipoxygenase and anti-inflammatory activity and comparable cytocompatibility to spermidine. (C) 2012 Elsevier Ltd. All rights reserved.

  （E）-4-（富勒烯吡咯基）-3-甲基丁二烯酸和对应的丙二酸 succeedinimidyl 酯通过普拉托型修饰C-60易得，被广泛应用于富选择性N-酰化反应。由此获得的共轭体被评估为抗氧化及抗炎活性，同时测定它们的细胞毒性。本系列化合物显示出令人感兴趣的抗脂过氧化、抗氧酶活性及抗炎活性，且与苏丹类物质相比具有相近的细胞相容性。（C）2012 Elsevier Ltd. All rights reserved.
• Tetrazole Analogs of Amino Acids¹
  作者：J. M. McMANUS、ROBERT M. HERBST

  DOI：10.1021/jo01093a006

  日期：1959.11
• Efficient Syntheses of 5-Aminoalkyl-1<i>H</i>-tetrazoles and of Polyamines Incorporating Tetrazole Rings
  作者：Constantinos M. Athanassopoulos、Thomas Garnelis、Dimitrios Vahliotis、Dionissios Papaioannou

  DOI：10.1021/ol0477069

  日期：2005.2.1

  Linear N-omega-tritylated omega-amino th iobenzylam ides and N-alpha,N-omega-ditritylated polyamino mono- or bisthioamides were efficiently converted to the corresponding tetrazole derivatives upon treatment with azidotrimethylsilane under Mitsunobu reaction conditions.