Methyl 3-(bromomethyl)-2-methylbenzoate | 1379358-75-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 3-(bromomethyl)-2-methylbenzoate
• 英文别名: methyl 3-(bromomethyl)-2-methylbenzoate
• CAS: 1379358-75-4
• 化学式: C₁₀H₁₁BrO₂
• 分子量: 243.1
• InChiKey: DSQFMTAUGZXHOG-UHFFFAOYSA-N

物化性质

• 沸点：
  299.6±28.0 °C(Predicted)
• 密度：
  1.404±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Methyl 3-(bromomethyl)-2-methylbenzoate 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 methyl 3-(azidomethyl)-2-methylbenzoate
  参考文献：
  名称：

  ANTIVIRAL COMPOUNDS AND USE THEREOF

  摘要：

  这项发明涉及化合物、药物组合物和用于治疗病毒感染的方法。

  公开号：

  US20090275583A1
• 作为产物：
  描述：

  2,3-二甲基苯甲酸甲酯 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 以 四氯化碳 为溶剂， 反应 4.0h， 生成 Methyl 3-(bromomethyl)-2-methylbenzoate
  参考文献：
  名称：

  ANTIVIRAL COMPOUNDS AND USE THEREOF

  摘要：

  这项发明涉及化合物、药物组合物和用于治疗病毒感染的方法。

  公开号：

  US20090275583A1

文献信息

• [EN] CHEMICAL COMPOUNDS FOR COATING OF NANOSTRUCTURES<br/>[FR] COMPOSÉS CHIMIQUES POUR LE REVÊTEMENT DE NANOSTRUCTURES
  申请人：SPAGO NANOMEDICAL AB

  公开号：WO2018130713A1

  公开（公告）日：2018-07-19

  The present application relates to a chemical compound comprising an aromatic core, or a carbocyclic, non-aromatic, core, wherein the aromatic core is a benzene ring or a biphenyl; the carbocyclic, non-aromatic core is a 5 to 7 membered ring. The core has covalently attached thereto: at least two anchoring groups, each anchoring group comprising an activated silane group, wherein the anchoring groups have the following general formula –A-(CH2)nSiY3 wherein A is a covalent bond or O, "n" is an integer from 1 to 3, and Y is independently a methoxy group or an ethoxy group; and at least one hydrophilic group extending from the core, the hydrophilic group comprising one or more hydrophilic polymer residues with a molecular composition of (aO+bN)/(cC+dS+eSi+fP) > 0.3 where a, b, c, d, e and f are the mol percentage of oxygen (O), nitrogen (N), carbon (C), sulfur (S), silicon (Si) and phosphorus (P), respectively; wherein the hydrophilic polymer residue(s) is(are) selected, independently of each other if more than one hydrophilic group is present, from –(O-CH2-CH2)m-OX, wherein X is CH3 or H, and "m" is an integer from 6 to 25; and the number of hydrophilic groups extending from the core is from one to the number of ring structures in the core. The present invention also relates to compositions comprising the chemical compound and nanostructures comprising residues of the chemical compound as well as the use of such nanostructures. Furthermore, the invention relates to methods for obtaining the chemical compounds and the nanostructures.

  本申请涉及一种化合物，包括一个芳香核或一个碳环非芳香核，其中所述芳香核是苯环或联苯；所述碳环非芳香核是一个含有5至7个成员的环。核上共价连接有：至少两个锚定基团，每个锚定基团包括一个活化硅烷基团，其中锚定基团具有以下一般式-A-(CH2)nSiY3，其中A是一个共价键或O，"n"是1至3之间的整数，Y独立地是一个甲氧基或一个乙氧基；以及至少一个从核心延伸的亲水基团，所述亲水基团包括一个或多个亲水聚合物残基，其分子组成为(aO+bN)/(cC+dS+eSi+fP) > 0.3，其中a、b、c、d、e和f分别是氧（O）、氮（N）、碳（C）、硫（S）、硅（Si）和磷（P）的摩尔百分比；其中亲水聚合物残基独立地选择，如果存在多个亲水基团，则从-(O-CH2-CH2)m-OX中选择，其中X是CH3或H，"m"是从6到25的整数；从核心延伸的亲水基团的数量为一个到核心中的环结构数量。本发明还涉及包含所述化合物的组合物和包含所述化合物残基的纳米结构，以及使用这种纳米结构。此外，该发明涉及获得所述化合物和纳米结构的方法。
• CHEMICAL COMPOUNDS FOR COATING OF NANOSTRUCTURES
  申请人：Spago Nanomedical AB

  公开号：EP3348560A1

  公开（公告）日：2018-07-18

  The present application relates to a chemical compound comprising an aromatic core, or a carbocyclic, non-aromatic, core. The core has covalently attached thereto: at least two anchoring groups, each anchoring group comprising an activated silane group; and at least one hydrophilic group extending from the core, the hydrophilic group comprising one or more hydrophilic polymer residues with a molecular composition of (aO+bN)/(cC+dS+eSi+fP) > 0.3 where a, b, c, d, e and f are the mol percentage of oxygen (O), nitrogen (N), carbon (C), sulfur (S), silicon (Si) and phosphorus (P), respectively; and the number of hydrophilic groups extending from the core is from one to the number of ring structures in the core. The present invention also relates to compositions comprising the chemical compound and nanostructures comprising residues of the chemical compound as well as the use of such nanostructures. Furthermore, the invention relates to methods for obtaining the chemical compounds and the nanostructures.

  本申请涉及一种由芳香族核心或碳环、非芳香族核心组成的化合物。核心上共价连接有：至少两个锚定基团，每个锚定基团包括一个活化硅烷基团；以及至少一个从核心延伸出来的亲水基团，亲水基团包括一个或多个亲水聚合物残基，其分子组成为 (aO+bN)/(cC+dS+eSi+fP) > 0.3 其中，a、b、c、d、e 和 f 分别为氧 (O)、氮 (N)、碳 (C)、硫 (S)、硅 (Si) 和磷 (P) 的摩尔百分比；从核心延伸出的亲水基团的数目从 1 到核心中环结构的数目。本发明还涉及包含该化合物的组合物和包含该化合物残留物的纳米结构以及此类纳米结构的使用。此外，本发明还涉及获得化合物和纳米结构的方法。
• Chemical Compounds For Coating Of Nanostructures
  申请人：Spago Nanomedical AB

  公开号：US20190352459A1

  公开（公告）日：2019-11-21

  The present application relates to a chemical compound comprising an aromatic core, or a carbocyclic, non-aromatic, core, wherein the aromatic core is a benzene ring or a biphenyl; the carbocyclic, non-aromatic core is a 5 to 7 membered ring. The core has covalently attached thereto: at least two anchoring groups, each anchoring group comprising an activated silane group, wherein the anchoring groups have the following general formula -A-(CH 2 )nSiY3 wherein A is a covalent bond or O, “n” is an integer from 1 to 3, and Y is independently a methoxy group or an ethoxy group; and at least one hydrophilic group extending from the core, the hydrophilic group comprising one or more hydrophilic polymer residues with a molecular composition of (aO+bN)/(cC+dS+eSi+fP)>0.3 where a, b, c, d, e and f are the mol percentage of oxygen (O), nitrogen (N), carbon (C), sulfur (S), silicon (Si) and phosphorus (P), respectively; wherein the hydrophilic polymer residue(s) is(are) selected, independently of each other if more than one hydrophilic group is present, from —(O—CH 2 —CH 2 ) m —OX, wherein Xis CH 3 or H, and “m” is an integer from 6 to 25; and the number of hydrophilic groups extending from the core is from one to the number of ring structures in the core. The present invention also relates to compositions comprising the chemical compound and nanostructures comprising residues of the chemical compound as well as the use of such nanostructures. Furthermore, the invention relates to methods for obtaining the chemical compounds and the nanostructures.
• ANTIVIRAL COMPOUNDS AND USE THEREOF
  申请人：Yager Kraig

  公开号：US20090275583A1

  公开（公告）日：2009-11-05

  The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.

  这项发明涉及化合物、药物组合物和用于治疗病毒感染的方法。