6-Hydroxy-7-methoxy-1,2,3,4-tetrahydroisochinolin-1-carbonsaeure | 73154-72-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 6-Hydroxy-7-methoxy-1,2,3,4-tetrahydroisochinolin-1-carbonsaeure
• 英文别名: 6-hydroxy-7-methoxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid；6-Hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
• CAS: 73154-72-0
• 化学式: C₁₁H₁₃NO₄
• 分子量: 223.229
• InChiKey: LBHGKZDCDLDWRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-Hydroxy-7-methoxy-1,2,3,4-tetrahydroisochinolin-1-carbonsaeure 在 吡啶 、 盐酸 作用下， 生成 6-Hydroxy-7-methoxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid methyl ester
  参考文献：
  名称：

  Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors

  摘要：

  The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.10.026
• 作为产物：
  描述：

  异香兰素 在 palladium on activated charcoal lithium aluminium tetrahydride 、 ammonium acetate 、 氢气 、 potassium carbonate 、 溶剂黄146 作用下， 以 四氢呋喃 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 6-Hydroxy-7-methoxy-1,2,3,4-tetrahydroisochinolin-1-carbonsaeure
  参考文献：
  名称：

  Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors

  摘要：

  The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.10.026

文献信息

• FSH RECEPTOR ANTAGONISTS
  申请人：Merck Sharp & Dohme B.V.

  公开号：EP2763986B1

  公开（公告）日：2017-06-07
• Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors
  作者：Dawei Ma、Wengen Wu、Guoxin Yang、Jingya Li、Jia Li、Qizhuang Ye

  DOI：10.1016/j.bmcl.2003.10.026

  日期：2004.1

  The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups. (C) 2003 Elsevier Ltd. All rights reserved.