苯甲酸,2-羟基-,2-(2-羟基乙氧基)乙基酯 | 13461-41-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯甲酸,2-羟基-,2-(2-羟基乙氧基)乙基酯
• 英文名称: diethylene glycol monosalicylate
• 英文别名: 1-(2-hydroxy-ethoxy)-2-salicyloyloxy-ethane；1-(2-Hydroxy-aethoxy)-2-salicyloyloxy-aethan；2-(2-Hydroxyethoxy)ethyl 2-hydroxybenzoate
• CAS: 13461-41-1
• 化学式: C₁₁H₁₄O₅
• 分子量: 226.229
• InChiKey: SBVHPLZQHISNJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N,N-二乙基-1,1,2,3,3,3-六氟丙胺 、 苯甲酸,2-羟基-,2-(2-羟基乙氧基)乙基酯 以20%的产率得到
  参考文献：
  名称：

  VATANABE S.; FUJITA T.; SAKAMOTO M.; KURAMOCHI T., J. FLUOR. CHEM., 36,(1987) N 3, 361-372

  摘要：

  DOI：
• 作为产物：
  描述：

  二乙基酮醇 、 水杨酰氯 生成 苯甲酸,2-羟基-,2-(2-羟基乙氧基)乙基酯
  参考文献：
  名称：

  The two-step monsoon changes of the last deglaciation recorded in tropical Maar Lake Huguangyan, southern China

  摘要：

  The concentrations of biogenic silica, total organic carbon, total nitrogen and total hydrogen inferred from the sediments of tropical Maar Lake Huguangyan, southern China, provide a climate record of the last deglaciation with century resolution. The records fully demonstrate the existence of the two-step shape of the last deglaciation in tropic East Asia, and they point out noticeable differences between the low and high latitudes in the Northern Hemisphere. Thus, the Belling first warming at the last deglaciation in the low latitude may have preceded that of the high latitude, whereas the cooling of the Younger Dryas occurred synchronously in the two regions. These results likely suggest that the links between the low and high latitude climates in the Northern Hemisphere during this period are complexity.

  DOI：

  10.1007/bf02898903

文献信息

• Antibacterial, antifungal activities and toxicity of new synthetic fatty acid salicylate esters
  作者：Monique B. Ewonkem、Pascaline M. Deussom、Michel A. Mbock、Eunice N. Tiakouang、Alfred F. A. Toze、Duplex J. Wansi

  DOI：10.1007/s00044-023-03034-w

  日期：2023.4

  myristic) and unsaturated long-chain (oleic, linoleic, eleostearic) fatty acid units quenched the antimicrobial activity. Also, esterifying the phenolic OH and increasing the number of benzene ring reduced, on one hand the antibacterial activity of the compounds bearing the palmitic acid and, on the other, increased their antifungal activity. Acute toxicity experiments revealed that mono salicyl-palmitate is

  微生物威胁及其对现有药物的耐药性是全球科学家正在努力解决的公共卫生问题。在发现传统药物之前，脂肪酸和水杨酸衍生物等天然产物已显示出对抗病原体的功效，如今，它们被认为是下一代抗菌剂。本研究旨在制备新型抗菌抗真菌药物，以脂肪酸和水杨酸盐衍生物为原料，设计合成了24种新型水杨酸盐-脂肪酸，并在多种细菌和真菌菌株上进行了体外试验。结果发现，与棕榈酸共价连接的水杨酸盐具有良好（MIC = 31.25 μg/ml）和中等（MIC = 62.5 和 125 μg/ml）抗菌和抗真菌活性肺炎链球菌、金黄色葡萄球菌、伤寒杆菌、肺炎克雷伯菌、大肠杆菌、须癣毛癣菌、奥杜氏小孢子菌、絮状表皮癣菌和石膏小孢子菌. 据观察，饱和中链（月桂酸、肉豆蔻酸）和不饱和长链（油酸、亚油酸、桐酸）脂肪酸单元会抑制抗菌活性。此外，酯化酚羟基和增加苯环数量一方面降低了带有棕榈酸的化合物的抗菌活性，另一方面增加了它们的抗真菌活性。急性
• Reactions of monoesters of ethylene glycol with N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine
  作者：S. Watanabe、T. Fujita、M. Sakamoto、T. Kuramochi、T. Kitazume

  DOI：10.1016/s0022-1139(00)82078-3

  日期：1987.8
• VATANABE S.; FUJITA T.; SAKAMOTO M.; KURAMOCHI T., J. FLUOR. CHEM., 36,(1987) N 3, 361-372
  作者：VATANABE S.、 FUJITA T.、 SAKAMOTO M.、 KURAMOCHI T.

  DOI：——

  日期：——
• The two-step monsoon changes of the last deglaciation recorded in tropical Maar Lake Huguangyan, southern China
  作者：Wenyuan Wang、Jiaqi Liu、Dongsheng Liu、Tungsheng Liu、Ping’an Peng、Houyuan Lu、Zhaoyan Gu、Guoqiang Chu、J. Negendank、Xiangjun Luo、J. Mingram

  DOI：10.1007/bf02898903

  日期：2000.8

  The concentrations of biogenic silica, total organic carbon, total nitrogen and total hydrogen inferred from the sediments of tropical Maar Lake Huguangyan, southern China, provide a climate record of the last deglaciation with century resolution. The records fully demonstrate the existence of the two-step shape of the last deglaciation in tropic East Asia, and they point out noticeable differences between the low and high latitudes in the Northern Hemisphere. Thus, the Belling first warming at the last deglaciation in the low latitude may have preceded that of the high latitude, whereas the cooling of the Younger Dryas occurred synchronously in the two regions. These results likely suggest that the links between the low and high latitude climates in the Northern Hemisphere during this period are complexity.