3,5-Diphenylhydantoin | 85369-75-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3,5-Diphenylhydantoin
• 英文别名: 3,5-diphenyl-imidazolidine-2,4-dione；3,5-Diphenyl-imidazolidin-2,4-dion；3,5-diphenyl-hydantoine；3,5-Diphenyl-2,4-imidazolidinedione；3,5-diphenylimidazolidine-2,4-dione
• CAS: 85369-75-1
• 化学式: C₁₅H₁₂N₂O₂
• 分子量: 252.272
• InChiKey: FLVDOHISKDLMSG-UHFFFAOYSA-N

物化性质

• 熔点：
  224-225 °C
• 密度：
  1.279±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,5-Diphenylhydantoin 在 溴 、 溶剂黄146 作用下， 生成 1,4,1',4'-tetraphenyl-tetrahydro-[4,4']biimidazolyltetraone
  参考文献：
  名称：

  Holmberg, Acta Chemica Scandinavica (1947), 1950, vol. 4, p. 821,823, 824, 825

  摘要：

  DOI：
• 作为产物：
  描述：

  phenyl-(N'-phenyl-ureido)-acetic acid 在 盐酸 作用下， 反应 2.0h， 生成 3,5-Diphenylhydantoin
  参考文献：
  名称：

  Synthesis and nitrosation of 3- and 3,5-substituted hydantoins

  摘要：

  DOI：

  10.1007/bf00503612

文献信息

• Prodrugs of NH-Acidic Compounds: Ester, Carbonate, Carbamate and Phosphonate Derivatives
  申请人：Alkermes Pharma Ireland Limited

  公开号：US20150320875A1

  公开（公告）日：2015-11-12

  The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.

  本发明提供了一种持续释放内酰胺、亚胺、酰胺、磺酰胺、氨基甲酸酯或尿素含量的母药的方法，通过向患者施用本发明的前药化合物的有效量，在患者体内释放母药的速率是持续释放的。适用于本发明方法的前药化合物是通过羰基偶联的前药基团衍生的母药的不稳定结合物。本发明的前药化合物可用于治疗任何需要内酰胺、亚胺、酰胺、磺酰胺、氨基甲酸酯或尿素含量的母药治疗的疾病。
• Prodrugs of NH-acidic compounds
  申请人：Alkermes Pharma Ireland Limited

  公开号：US10040787B2

  公开（公告）日：2018-08-07

  The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.

  本发明提供了一种持续给药含有内酰胺、酰亚胺、酰胺、磺酰胺、氨基甲酸酯或脲的母体药物的方法，其方法是向患者给药有效量的本发明原药化合物，给药后，母体药物从原药中持续释放。适用于本发明方法的原药化合物是通过羰基连接的原药分子进行衍生的母药的易变共轭物。本发明的原药化合物可用于治疗任何含有内酰胺、亚胺、酰胺、磺酰胺、氨基甲酸酯或脲的母药可用于治疗的病症。
• Prodrugs of Nh-acidic compounds
  申请人：ALKERMES PHARMA IRELAND LIMITED

  公开号：US10723728B2

  公开（公告）日：2020-07-28

  The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.

  本发明提供了一种持续给药含有内酰胺、酰亚胺、酰胺、磺酰胺、氨基甲酸酯或脲的母体药物的方法，其方法是向患者给药有效量的本发明原药化合物，给药后，母体药物从原药中持续释放。适用于本发明方法的原药化合物是通过羰基连接的原药分子进行衍生的母药的易变共轭物。本发明的原药化合物可用于治疗任何含有内酰胺、亚胺、酰胺、磺酰胺、氨基甲酸酯或脲的母药可用于治疗的病症。
• Machacek, Vladimir; Svobodova, Gabriela; Sterba, Vojeslav, Collection of Czechoslovak Chemical Communications, 1987, vol. 52, # 1, p. 140 - 155
  作者：Machacek, Vladimir、Svobodova, Gabriela、Sterba, Vojeslav

  DOI：——

  日期：——
• Kjaer, Acta Chemica Scandinavica (1947), 1950, vol. 4, p. 892,893, 897
  作者：Kjaer

  DOI：——

  日期：——