1-(3-hydroxy-3,3-diphenylpropyl)cyclohexanol | 58607-49-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-hydroxy-3,3-diphenylpropyl)cyclohexanol
• 英文别名: 1-(3-Hydroxy-3,3-diphenylpropyl)cyclohexan-1-ol
• CAS: 58607-49-1
• 化学式: C₂₁H₂₆O₂
• 分子量: 310.436
• InChiKey: LWIZFKNQTJIUDQ-UHFFFAOYSA-N

物化性质

• 熔点：
  93-94 °C
• 沸点：
  477.0±25.0 °C(predicted)
• 密度：
  1.116±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-(1-hydroxy-cyclohexyl)-1,1-diphenyl-prop-2-yn-1-ol 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 1-(3-hydroxy-3,3-diphenylpropyl)cyclohexanol
  参考文献：
  名称：

  取代的2,2'-氧双（丙酸）衍生物和相关化合物的合成和生物学评估。

  摘要：

  DOI：

  10.1021/jm00227a024

文献信息

• Copper-catalyzed aerobic aliphatic C–H oxygenation with hydroperoxides
  作者：Pei Chui Too、Ya Lin Tnay、Shunsuke Chiba

  DOI：10.3762/bjoc.9.138

  日期：——

  We report herein Cu-catalyzed aerobic oxygenation of aliphatic C-H bonds with hydroperoxides, which proceeds by 1,5-H radical shift of putative oxygen-centered radicals (O-radicals) derived from hydroperoxides followed by trapping of the resulting carbon-centered radicals with molecular oxygen.

  我们在此报告了铜催化的脂肪族 CH 键与氢过氧化物的有氧氧化，其通过源自氢过氧化物的假定氧中心自由基（O 自由基）的 1,5-H 自由基位移进行，然后捕获所得的碳中心自由基与分子氧。
• Synthesis and Applications of Tetrahydrofuran-Stable Substituted (3-Lithioxyalkyl)- and (4-Lithioxyalkyl)lithiums, Modified with Magnesium 2-Ethoxyethoxide
  作者：Ioannis D. Kostas、Constantinos G. Screttas

  DOI：10.1021/jo9703010

  日期：1997.8.1

  Substituted hydroxyalkyl phenyl sulfides 3 have been synthesized from the corresponding allylic or homoallylic alcohols 2. Regiospecific cleavage of the C-SPh bond of the sulfides 3 by lithium dispersion in tetrahydrofuran (THF) led to the synthesis of substituted (3-lithioxyalkyl)- and (4-lithioxyalkyl)lithiums 4, most of which share the omega carbon with a carbocyclic ring. The organolithiums were modified with magnesium 2-ethoxyethoxide in order to suppress their reactivity toward THF cleavage, thus offering the advantage of preparing storable ethereal solutions of certain types of (lithioxyalkyl)lithiums. This strategy appears to be of rather broad scope. The functionalized organolithiums prepared in this way react normally with electrophilic reagents with yields in the range 35-55%. Thus, carboxylations of 4 yielded lactones 5, some of which are natural products, while reactions of 4 with benzophenone and cyclic ketones yielded 1,4- and 1,5-diols 6 and 7, respectively.
• Synthesis and biological evaluation of substituted 2,2'-oxybis(propionic acid) derivatives and related compounds
  作者：Gregory B. Bennett、William J. Houlihan、Robert B. Mason、Robert G. Engstrom

  DOI：10.1021/jm00227a024

  日期：1976.5