4-[4-[Bis(2-chloroethyl)amino]phenyl]sulfinylaniline | 189639-00-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[4-[Bis(2-chloroethyl)amino]phenyl]sulfinylaniline
• CAS: 189639-00-7
• 化学式: C₁₆H₁₈Cl₂N₂OS
• 分子量: 357.304
• InChiKey: OYLHJJBKMNGFMY-UHFFFAOYSA-N

物化性质

• 熔点：
  136.5-138 °C
• 沸点：
  562.3±50.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  9-氯吖啶 、 4-[4-[Bis(2-chloroethyl)amino]phenyl]sulfinylaniline 在 盐酸 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 1.5h， 以88.4%的产率得到N-[4-[4-[bis(2-chloroethyl)amino]phenyl]sulfinylphenyl]acridin-9-amine;hydrochloride
  参考文献：
  名称：

  Sulfoxide-Containing Aromatic Nitrogen Mustards as Hypoxia-Directed Bioreductive Cytotoxins

  摘要：

  A series of diaryl and alkylaryl sulfoxide-containing nitrogen mustards were synthesized and evaluated for their hypoxia-selective cytotoxicity against V-79 cells in vitro as well as for their metabolism profiles with the rat S-9 fractions. In general, the diaryl sulfoxides (4, 5, and 7-9) showed much greater hypoxia selectivity (11-27-fold) than the alkylaryl sulfoxides (similar to3-fold) (1 and 3). The fused diphenyl sulfoxides (10 and 11), on the other hand, showed very low hypoxia selectivity (1.3-3-fold). Compound 10 was highly cytotoxic under both aerobic and anaerobic conditions, while 11 showed low cytotoxicity under both conditions. The bioreduction of 8 by the rat S-9 fraction under anaerobic conditions was inhibited by menadione and enhanced by benzaldehyde, acetaldehyde, or 2-hydroxypyrimidine suggesting the involvement of aldehyde oxidase in the reduction of the sulfoxides. Bioreductive metabolism studies of selected model sulfoxides suggested that diaryl sulfoxides are better substrates for aldehyde oxidase than alkylaryl sulfoxides.

  DOI：

  10.1021/jm9904957
• 作为产物：
  描述：

  4-nitrophenyl 4'-phenyl sulfide 在 盐酸 、 铁粉 、 三氟乙酸 、 三氯氧磷 作用下， 以 乙醇 为溶剂， 反应 3.42h， 生成 4-[4-[Bis(2-chloroethyl)amino]phenyl]sulfinylaniline
  参考文献：
  名称：

  Sulfoxide-Containing Aromatic Nitrogen Mustards as Hypoxia-Directed Bioreductive Cytotoxins

  摘要：

  A series of diaryl and alkylaryl sulfoxide-containing nitrogen mustards were synthesized and evaluated for their hypoxia-selective cytotoxicity against V-79 cells in vitro as well as for their metabolism profiles with the rat S-9 fractions. In general, the diaryl sulfoxides (4, 5, and 7-9) showed much greater hypoxia selectivity (11-27-fold) than the alkylaryl sulfoxides (similar to3-fold) (1 and 3). The fused diphenyl sulfoxides (10 and 11), on the other hand, showed very low hypoxia selectivity (1.3-3-fold). Compound 10 was highly cytotoxic under both aerobic and anaerobic conditions, while 11 showed low cytotoxicity under both conditions. The bioreduction of 8 by the rat S-9 fraction under anaerobic conditions was inhibited by menadione and enhanced by benzaldehyde, acetaldehyde, or 2-hydroxypyrimidine suggesting the involvement of aldehyde oxidase in the reduction of the sulfoxides. Bioreductive metabolism studies of selected model sulfoxides suggested that diaryl sulfoxides are better substrates for aldehyde oxidase than alkylaryl sulfoxides.

  DOI：

  10.1021/jm9904957

文献信息

• [EN] SULFOXIDE DERIVATIVES OF NITROGEN-MUSTARD AND ANTICANCER AGENT CONTAINING THE SAME<br/>[FR] DERIVES SULFOXYDES DE L'YPERITE AZOTEE ET AGENT ANTICANCEREUX LES CONTENANT
  申请人：CHONG KUN DANG CORP.

  公开号：WO1997013748A1

  公开（公告）日：1997-04-17

  (EN) According to the present invention, are provided sulfoxide derivatives of nitrogen-mustard represented by general formula (I), wherein R1 represents a hydrogen, or haloethyl; R2 represents a lower alkyl or phenyl group substituted or non-substituted; and X represents a halogen atom. Provided that R1 is a chloroethyl and X is a chlorine, R2 does not represent methyl group; and an anticancer agent comprising the same as a prodrug. The sulfoxide derivatives according to the present invention convert to a sulfide in a hypoxic condition to show cytotoxicity, so that it is very useful as an anticancer agent selectively functions on a solid cancer which is in a hypoxic condition.(FR) La présente invention concerne des dérivés sulfoxydes de l'ypérite azotée, représentés par la formule générale (I) dans laquelle R1 représente un hydrogène ou un haloéthyle; R2 représente un groupe alkyle ou phényle inférieur, substitué ou non, et X représente un atome d'halogène. A condition que R1 soit un chloroéthyle et X un chlore, R2 ne représente pas un groupe méthyle. L'invention concerne aussi un agent anticancéreux contenant un de ces constituants en tant que promédicament. Les dérivés sulfoxydes selon l'invention se transforment en sulfure dans des conditions hypoxiques, faisant alors preuve de cytotoxicité, de telle sorte qu'ils sont très utiles comme agents anticancéreux qui agissent de manière sélective sur les cancers dans des conditions hypoxiques.
• Sulfoxide-Containing Aromatic Nitrogen Mustards as Hypoxia-Directed Bioreductive Cytotoxins
  作者：Zhong-Yue Sun、Emad Botros、Ai-Duen Su、Yu Kim、Enju Wang、Nesrine Z. Baturay、Chul-Hoon Kwon

  DOI：10.1021/jm9904957

  日期：2000.11.1

  A series of diaryl and alkylaryl sulfoxide-containing nitrogen mustards were synthesized and evaluated for their hypoxia-selective cytotoxicity against V-79 cells in vitro as well as for their metabolism profiles with the rat S-9 fractions. In general, the diaryl sulfoxides (4, 5, and 7-9) showed much greater hypoxia selectivity (11-27-fold) than the alkylaryl sulfoxides (similar to3-fold) (1 and 3). The fused diphenyl sulfoxides (10 and 11), on the other hand, showed very low hypoxia selectivity (1.3-3-fold). Compound 10 was highly cytotoxic under both aerobic and anaerobic conditions, while 11 showed low cytotoxicity under both conditions. The bioreduction of 8 by the rat S-9 fraction under anaerobic conditions was inhibited by menadione and enhanced by benzaldehyde, acetaldehyde, or 2-hydroxypyrimidine suggesting the involvement of aldehyde oxidase in the reduction of the sulfoxides. Bioreductive metabolism studies of selected model sulfoxides suggested that diaryl sulfoxides are better substrates for aldehyde oxidase than alkylaryl sulfoxides.