[2.2]paracyclophan-4-yl-acetic acid | 17227-61-1

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: [2.2]paracyclophan-4-yl-acetic acid
• 英文别名: [2.2]Paracyclophan-4-yl-essigsaeure；4-Carboxymethyl-<2,2>-paracyclophan；4-Carboxymethyl-<2.2>paracyclophan；Tricyclo(8.2.2.2(4,7))hexadeca-hexaen-5-YL-acetic acid；2-(5-tricyclo[8.2.2.24,7]hexadeca-1(13),4,6,10(14),11,15-hexaenyl)acetic acid
• CAS: 17227-61-1
• 化学式: C₁₈H₁₈O₂
• 分子量: 266.34
• InChiKey: HPVWTTADFYYPAZ-UHFFFAOYSA-N

物化性质

• 沸点：
  430.674±14.00 °C(Press: 760.00 Torr)(predicted)
• 密度：
  1.163±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [2.2]paracyclophan-4-yl-acetic acid 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 4-(2-Hydroxyethyl)-<2.2>paracyclophan
  参考文献：
  名称：

  Macro Rings. XXVI. [2.2]Paracyclophanyl as a Neighboring Group

  摘要：

  DOI：

  10.1021/ja00891a010
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 吗啉 、 sulfur 作用下， 生成 [2.2]paracyclophan-4-yl-acetic acid
  参考文献：
  名称：

  Macro Rings. XXI. Mono- and Polysubstituted [2.2]Paracyclophanes¹

  摘要：

  DOI：

  10.1021/ja01531a032

文献信息

• [EN] NEW AMINOTETRALINE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS D'AMINOTÉTRALINE
  申请人：GMEINER PETER

  公开号：WO2011076708A1

  公开（公告）日：2011-06-30

  The present application relates to compounds of formula (I): and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds in producing medicaments for the treatment of various diseases and conditions, such as of the central nervous system.

  本申请涉及以下式（I）的化合物：及其药学上可接受的盐和溶剂，其中取代基如本文所定义，含有这种化合物的组合物以及利用这种化合物生产用于治疗各种疾病和症状的药物，如中枢神经系统疾病。
• New aminotetraline derivatives
  申请人：Gmeiner, Peter

  公开号：EP2338873A1

  公开（公告）日：2011-06-29

  The present application relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds in producing medicaments for the treatment of various diseases and conditions, such as of the central nervous system.

  本申请涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中取代基如本文所定义，含有这种化合物的组合物以及利用这种化合物制备治疗各种疾病和病情的药物，例如中枢神经系统疾病和病情。
• NEW AMINOTETRALINE DERIVATIVES
  申请人：Gmeiner Peter

  公开号：US20120277262A1

  公开（公告）日：2012-11-01

  The present application relates to compounds of formula (I): and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds in producing medicaments for the treatment of various diseases and conditions, such as of the central nervous system.

  本申请涉及式(I)的化合物及其药学上可接受的盐和溶剂化合物，其中取代基如此定义，含有这种化合物的组合物以及在制备治疗各种疾病和病症的药物中使用这种化合物的用途，例如中枢神经系统的疾病和病症。
• AMINOTETRALINE DERIVATIVES
  申请人：Gmeiner Peter

  公开号：US20130331429A1

  公开（公告）日：2013-12-12

  The present application relates generally to amino tetraline derivative compounds and methods of use, specifically, embodiments including compounds of formula (I) described herein, pharmaceutically acceptable salts and solvates. More specifically, this application relates to amino tetraline derivative compounds and uses of such compounds producing medicaments for the treatment of various disease and conditions including movement disorders and disorders of the central nervous system.

  本申请涉及氨基四氢萘衍生物化合物及其使用方法，具体包括本文所述的式（I）化合物、药学上可接受的盐和溶剂的实施方式。更具体地说，本申请涉及氨基四氢萘衍生物化合物及其使用，用于制备治疗各种疾病和病症的药物，包括运动障碍和中枢神经系统疾病和病症。
• Macro rings. XXXV. Stereochemistry of [2.2]paracyclophanyl nucleus as a neighboring group in solvolyses reactions
  作者：Donald James. Cram、Francis Laurie. Harris

  DOI：10.1021/ja00994a014

  日期：1967.8