(6-methylpyridin-2-yl)magnesium chloride | 1164199-73-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (6-methylpyridin-2-yl)magnesium chloride
• CAS: 1164199-73-8
• 化学式: C₆H₆ClMgN
• 分子量: 151.878
• InChiKey: SCKCEBKMFGUARK-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.87
• 重原子数：
  9.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  12.89
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (6-methylpyridin-2-yl)magnesium chloride 、 N,N-二甲基-4-甲基苯甲酰胺 以 四氢呋喃 为溶剂， 反应 1.0h， 以5.5 g的产率得到(6-methylpyridin-2-yl)(p-tolyl)methanone
  参考文献：
  名称：

  Preferential Reactivity of Pyridylmagnesiumchloride with N,N-Dialkyl Arylamides over Carbonitriles: Synthesis of 2-(Aroyl) Pyridines

  摘要：

  Reaction of 2-pyridylmagnesium chlorides with N,N-dialkyl arylamides afford exclusively 2-(aroyl) pyridines in high yields and purity without the formation of any tertiary alcohol. This method employs easily available raw materials and avoids the use of hazardous lithium reagents and cryogenic conditions. Further, preferential reactivity of this Grignard reagent with N,N-dialkyl arylamides over its carbonitrile counterparts offers a variety of 2-(aroyl) pyridines including the ones containing carbonitrile groups on the aryl ring.

  DOI：

  10.1080/00397910802594284
• 作为产物：
  描述：

  2-溴-6-甲基吡啶 、 异丙基氯化镁 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 (6-methylpyridin-2-yl)magnesium chloride
  参考文献：
  名称：

  Preferential Reactivity of Pyridylmagnesiumchloride with N,N-Dialkyl Arylamides over Carbonitriles: Synthesis of 2-(Aroyl) Pyridines

  摘要：

  Reaction of 2-pyridylmagnesium chlorides with N,N-dialkyl arylamides afford exclusively 2-(aroyl) pyridines in high yields and purity without the formation of any tertiary alcohol. This method employs easily available raw materials and avoids the use of hazardous lithium reagents and cryogenic conditions. Further, preferential reactivity of this Grignard reagent with N,N-dialkyl arylamides over its carbonitrile counterparts offers a variety of 2-(aroyl) pyridines including the ones containing carbonitrile groups on the aryl ring.

  DOI：

  10.1080/00397910802594284