4-chloro-6-(methylsulfanyl)[1,3]thiazolo[4,5-d][1,2,3]triazine | 1069114-88-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-chloro-6-(methylsulfanyl)[1,3]thiazolo[4,5-d][1,2,3]triazine
• 英文别名: 4-Chloro-6-methylsulfanyl-[1,3]thiazolo[4,5-d]triazine；4-chloro-6-methylsulfanyl-[1,3]thiazolo[4,5-d]triazine
• CAS: 1069114-88-0
• 化学式: C₅H₃ClN₄S₂
• 分子量: 218.691
• InChiKey: UWBNZUDGKXMEDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  四氢吡咯 、 4-chloro-6-(methylsulfanyl)[1,3]thiazolo[4,5-d][1,2,3]triazine 反应 6.0h， 以55%的产率得到4,6-di(1-pyrrolidinyl)[1,3]thiazolo[4,5-d][1,2,3]triazine
  参考文献：
  名称：

  Synthesis of substituted [1,3]thiazolo[4,5-b]pyridines and [1,3]thiazolo[4,5-d][1,2,3]triazines

  摘要：

  In this work, we described an easy preparation Of substituted 4-amino-5-cyano-1,3-thiazoles. These compounds have been used as starting materials to obtain two classes of compounds. New substituted [1,3]thiazolo[4,5-e]pyridines were synthesized in one step via Friedlander reaction. Diazotation of 4-amino-5-cyano-1,3-thiazoles afforded 4-chloro[1,3]thiazolo[4,5-d][1,2,3]triazines in one step. The later Was substituted by a secondary amine to obtain substituted 4-amino[1,3]thiazolo[4,5-d][1,2,3]triazines. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.07.017
• 作为产物：
  描述：

  4-氨基-2-甲基硫代噻唑-5-甲腈 在 盐酸 、 sodium nitrite 作用下， 以83%的产率得到4-chloro-6-(methylsulfanyl)[1,3]thiazolo[4,5-d][1,2,3]triazine
  参考文献：
  名称：

  Synthesis of substituted [1,3]thiazolo[4,5-b]pyridines and [1,3]thiazolo[4,5-d][1,2,3]triazines

  摘要：

  In this work, we described an easy preparation Of substituted 4-amino-5-cyano-1,3-thiazoles. These compounds have been used as starting materials to obtain two classes of compounds. New substituted [1,3]thiazolo[4,5-e]pyridines were synthesized in one step via Friedlander reaction. Diazotation of 4-amino-5-cyano-1,3-thiazoles afforded 4-chloro[1,3]thiazolo[4,5-d][1,2,3]triazines in one step. The later Was substituted by a secondary amine to obtain substituted 4-amino[1,3]thiazolo[4,5-d][1,2,3]triazines. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.07.017

文献信息

• Synthesis of substituted [1,3]thiazolo[4,5-b]pyridines and [1,3]thiazolo[4,5-d][1,2,3]triazines
  作者：David Thomae、Enrico Perspicace、Stéphanie Hesse、Gilbert Kirsch、Pierre Seck

  DOI：10.1016/j.tet.2008.07.017

  日期：2008.9

  In this work, we described an easy preparation Of substituted 4-amino-5-cyano-1,3-thiazoles. These compounds have been used as starting materials to obtain two classes of compounds. New substituted [1,3]thiazolo[4,5-e]pyridines were synthesized in one step via Friedlander reaction. Diazotation of 4-amino-5-cyano-1,3-thiazoles afforded 4-chloro[1,3]thiazolo[4,5-d][1,2,3]triazines in one step. The later Was substituted by a secondary amine to obtain substituted 4-amino[1,3]thiazolo[4,5-d][1,2,3]triazines. (C) 2008 Elsevier Ltd. All rights reserved.