ethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate | 1428526-25-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate
• 英文别名: ethoxy-[4-[[(6-oxo-2-pyridin-2-yl-1H-pyrimidine-5-carbonyl)amino]-phenylmethyl]phenyl]phosphinic acid
• CAS: 1428526-25-3
• 化学式: C₂₅H₂₃N₄O₅P
• 分子量: 490.455
• InChiKey: RJZZQQWOMNYTTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  130
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-(4-bromo-benzhydryl)-formamide 在 盐酸 、 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 三乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 potassium hydroxide 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 甲醇 、 二氯甲烷 、 甲苯 、 乙腈 为溶剂， 反应 10.0h， 生成 ethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate
  参考文献：
  名称：

  [EN] SUBSTITUTED PYRIMIDINES
  [FR] PYRIMIDINES SUBSTITUÉES

  摘要：

  公开了作为HIF脯氨酰羟化酶抑制剂的有用取代嘧啶，用于治疗贫血及类似病症。

  公开号：

  WO2013040790A1

文献信息

• SUBSTITUTED PYRIMIDINES
  申请人：MERCK SHARP & DOHME CORP

  公开号：US20140349972A1

  公开（公告）日：2014-11-27

  The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

  本发明涉及替代嘧啶类化合物，用于治疗贫血和类似疾病的HIF脯氨酸羟化酶抑制剂。
• MULTI-FUNCTIONAL NUCLEIC ACID-BASED ANTI-CANCER DRUG CAPABLE OF TARGETING AND THERAPY, METHOD FOR PREPARING SAME AND ANTI-CANCER COMPOSITION COMPRISING SAME
  申请人：RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY

  公开号：US20140350230A1

  公开（公告）日：2014-11-27

  The present invention relates to a multi-functional nucleic acid-based anti-cancer drug in which the anti-cancer drug is physically bound to a linear nucleic acid having a thiol group at 5′ terminal thereof and then gold nanoparticles and aptamers are chemically bound. The present invention also relates to a method for preparing the anti-cancer drug and to an anti-cancer composition comprising the anti-cancer drug. The multi-functional nucleic acid-based anti-cancer drug according to the present invention uses A10 aptamer to achieve high targeting properties, and uses high-concentration anti-cancer drugs and gold nanoparticles to enable dual therapy of thermal therapy/chemical therapy, and may have less side effects and be more effective in anti-cancer therapy compared to existing anti-cancer drugs.
• US9079930B2
  申请人：——

  公开号：US9079930B2

  公开（公告）日：2015-07-14
• US9163048B2
  申请人：——

  公开号：US9163048B2

  公开（公告）日：2015-10-20