1-(2-methyl-4-vinyl-[1,3]dioxan-5-yloxy)-3-(triphenyl-λ5-phosphanylidene)-propan-2-one | 934279-13-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 英文名称: 1-(2-methyl-4-vinyl-[1,3]dioxan-5-yloxy)-3-(triphenyl-λ5-phosphanylidene)-propan-2-one
• CAS: 934279-13-7
• 化学式: C₂₈H₂₉O₄P
• 分子量: 460.51
• InChiKey: KJBIXLBXLJTWSR-KKVCJECGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.68
• 重原子数：
  33.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  44.76
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1-(2-methyl-4-vinyl-[1,3]dioxan-5-yloxy)-3-(triphenyl-λ5-phosphanylidene)-propan-2-one 、 聚合甲醛 以 乙醚 为溶剂， 以97%的产率得到1-[[(2R,4S,5R)-4-ethenyl-2-methyl-1,3-dioxan-5-yl]oxy]but-3-en-2-one
  参考文献：
  名称：

  Synthesis of the Fused Polyether Core of Hemibrevetoxin B by Two-Directional Ring-Closing Metathesis

  摘要：

  The tetracyclic fused polyether core of the marine natural product hemibrevetoxin B has been prepared in an efficient manner by using a strategy in which ring-closing metathesis (RCM) reactions were employed for ring synthesis. Simultaneous construction of the A and D rings was accomplished by double two-directional RCM of a tetraene.

  DOI：

  10.1021/ol0630651
• 作为产物：
  描述：

  (1’R)-(-)-4,6-O-ethylidene-D-glucose 在 sodium periodate 、 四丁基碘化铵 、 sodium hydride 、 碳酸氢钠 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 生成 1-(2-methyl-4-vinyl-[1,3]dioxan-5-yloxy)-3-(triphenyl-λ5-phosphanylidene)-propan-2-one
  参考文献：
  名称：

  Synthesis of the Fused Polyether Core of Hemibrevetoxin B by Two-Directional Ring-Closing Metathesis

  摘要：

  The tetracyclic fused polyether core of the marine natural product hemibrevetoxin B has been prepared in an efficient manner by using a strategy in which ring-closing metathesis (RCM) reactions were employed for ring synthesis. Simultaneous construction of the A and D rings was accomplished by double two-directional RCM of a tetraene.

  DOI：

  10.1021/ol0630651