tri-isobutylphosphane hydrobromide | 1241896-39-8

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 英文名称: tri-isobutylphosphane hydrobromide
• 英文别名: triisobutylphosphane hydrobromide；triisobutylphosphonium bromide；i-Bu3P*HBr；iBu3PHBr；Tris(2-methylpropyl)phosphane;hydrobromide
• CAS: 1241896-39-8
• 化学式: BrH*C₁₂H₂₇P
• 分子量: 283.232
• InChiKey: LHFQRFNBPJJZGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.01
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  tri-isobutylphosphane hydrobromide 、 反式二苯乙烯-4-甲醇 反应 0.5h， 以99%的产率得到(E)-triisobutyl(4-styrylbenzyl)phosphonium bromide
  参考文献：
  名称：

  An iterative approach toward the synthesis of discrete oligomeric p-phenylene vinylene organic dyes employing aqueous Wittig chemistry

  摘要：

  Photovoltaic research has become increasingly prominent as the search for alternatives to fossil fuels are actively sought. A novel process for the iterative synthesis of discrete donor/acceptor-flanked oligostilbenes, key constituents in dye-sensitized solar cells, is described. The aqueous Wittig process is high yielding, proceeds with high (E)-stereoselectivity and allows facile product purification. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.040
• 作为产物：
  描述：

  三异丁基磷烷 在 氢溴酸 作用下， 以 水 为溶剂， 以99%的产率得到tri-isobutylphosphane hydrobromide
  参考文献：
  名称：

  三乙基和三苯基膦盐与二甲基缩醛反应中的二分反应性：α-烷氧基官能化叶立德的新入口和乙烯基醚和烷氧基二烯的一般合成

  摘要：

  三烷基与三苯基膦 HBr 盐与缩醛反应中二分反应性的发现允许进入官能化的 α-甲氧基鏻盐和叔膦甲基化的新方法。新协议打开了合成乙烯基醚和差异取代的 1,3-二烯的通用入口，通过来自 α-甲氧基鏻盐的官能化叶立德的 Wittig 反应。

  DOI：

  10.1002/ejoc.201000601

文献信息

• A convergent synthesis of the immunosuppressant FTY720 employing aqueous Wittig chemistry
  作者：Janice Calzavara、James McNulty

  DOI：10.1016/j.tetlet.2011.08.100

  日期：2011.10

  A short, convergent synthesis of the immunosuppressant FTY720 is described involving the use of 4-hydroxymethylbenzaldehyde as a pivotal intermediate. A double Wittig strategy was developed to connect this dual-functional aldehyde with an alkyl-tether and to a readily available TRIS-derivative leading to an efficient synthesis of the target molecule. (C) 2011 Elsevier Ltd. All rights reserved,
• An iterative approach toward the synthesis of discrete oligomeric p-phenylene vinylene organic dyes employing aqueous Wittig chemistry
  作者：James McNulty、David McLeod

  DOI：10.1016/j.tetlet.2011.08.040

  日期：2011.10

  Photovoltaic research has become increasingly prominent as the search for alternatives to fossil fuels are actively sought. A novel process for the iterative synthesis of discrete donor/acceptor-flanked oligostilbenes, key constituents in dye-sensitized solar cells, is described. The aqueous Wittig process is high yielding, proceeds with high (E)-stereoselectivity and allows facile product purification. (C) 2011 Elsevier Ltd. All rights reserved.
• Dichotomous Reactivity in the Reaction of Triethyl- and Triphenylphosphane HBr Salts with Dimethyl Acetals: A Novel Entry to α-Alkoxy-Functionalized Ylides and General Synthesis of Vinyl Ethers and Alkoxy Dienes
  作者：Priyabrata Das、James McNulty

  DOI：10.1002/ejoc.201000601

  日期：2010.7

  discovery of dichotomous reactivity in the reaction of trialkyl- vs. triphenylphosphane HBr salts with acetals allows entry to functionalized α-methoxy phosphonium salts and a novel process for tertiary phosphane methylation. The new protocol opens a general entry to the synthesis of vinyl ethers and differentially substituted 1,3-dienes via Wittig reactions of the functionalized ylides derived from

  三烷基与三苯基膦 HBr 盐与缩醛反应中二分反应性的发现允许进入官能化的 α-甲氧基鏻盐和叔膦甲基化的新方法。新协议打开了合成乙烯基醚和差异取代的 1,3-二烯的通用入口，通过来自 α-甲氧基鏻盐的官能化叶立德的 Wittig 反应。