biphenyl-4-yl-(dichloro-[1,3,5]triazin-2-yl)-amine | 30369-86-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: biphenyl-4-yl-(dichloro-[1,3,5]triazin-2-yl)-amine
• 英文别名: Biphenyl-4-yl-(dichlor-[1,3,5]triazin-2-yl)-amin；N-(4-Biphenylyl)-4,6-dichloro-s-triazine-2-amine；4,6-dichloro-N-(4-phenylphenyl)-1,3,5-triazin-2-amine
• CAS: 30369-86-9
• 化学式: C₁₅H₁₀Cl₂N₄
• 分子量: 317.177
• InChiKey: XWBYFHVYOKMYCO-UHFFFAOYSA-N

物化性质

• 沸点：
  533.7±43.0 °C(Predicted)
• 密度：
  1.413±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  biphenyl-4-yl-(dichloro-[1,3,5]triazin-2-yl)-amine 在 盐酸 、 碳酸氢钠 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 为溶剂， 生成 (3S,5R)-1-[4-[(3R,5S)-3,5-diaminopiperidin-1-yl]-6-(4-phenylanilino)-1,3,5-triazin-2-yl]piperidine-3,5-diamine
  参考文献：
  名称：

  Structure–activity relationships of novel antibacterial translation inhibitors: 3,5-Diamino-piperidinyl triazines

  摘要：

  Structure-activity relationships of the 3,5-diamino-piperidinyl triazine series, a novel class of bacterial translation inhibitors, are described. Optimization was focused on the triazine C-4 position in which aromatic substituents that contained electron-withdrawing groups led to potent inhibitors. The initial lack of antibacterial activity was correlated with poor cellular penetration. Whole cell antibacterial activity was achieved by linking additional aromatic moieties at the triazine C-4 position. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.07.052
• 作为产物：
  描述：

  三聚氯氰 、 4-氨基联苯 在 碳酸氢钠 作用下， 以 四氢呋喃 为溶剂， 反应 0.67h， 生成 biphenyl-4-yl-(dichloro-[1,3,5]triazin-2-yl)-amine
  参考文献：
  名称：

  Structure–activity relationships of novel antibacterial translation inhibitors: 3,5-Diamino-piperidinyl triazines

  摘要：

  Structure-activity relationships of the 3,5-diamino-piperidinyl triazine series, a novel class of bacterial translation inhibitors, are described. Optimization was focused on the triazine C-4 position in which aromatic substituents that contained electron-withdrawing groups led to potent inhibitors. The initial lack of antibacterial activity was correlated with poor cellular penetration. Whole cell antibacterial activity was achieved by linking additional aromatic moieties at the triazine C-4 position. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.07.052

文献信息

• [EN] mTORC1 INHIBITORS FOR ACTIVATING AUTOPHAGY<br/>[FR] INHIBITEURS DE MTORC1 POUR ACTIVER L'AUTOPHAGIE
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  公开号：WO2020146779A1

  公开（公告）日：2020-07-16

  Described herein, inter alia, are compounds and methods useful for increasing autophagy.

  本文描述了一些化合物和方法，用于增加自噬作用。
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  作者：Facundo N. Gallo、Agostina B. Marquez、Daniela M. Fidalgo、Alejandro Dana、Mariano Dellarole、Cybele C. García、Mariela Bollini

  DOI：10.1016/j.ejmech.2024.116465

  日期：2024.4

  Vector-borne diseases, constituting over 17 % of infectious diseases, are caused by parasites, viruses, and bacteria, and their prevalence is shaped by environmental and social factors. Dengue virus (DENV) and Zika virus (ZIKV), some of the most prevalent infectious agents of this type of diseases, are transmitted by mosquitoes belonging to the genus . The highest prevalence is observed in tropical

  媒介传播疾病由寄生虫、病毒和细菌引起，占传染病的 17% 以上，其流行程度受环境和社会因素影响。登革热病毒 (DENV) 和寨卡病毒 (ZIKV) 是此类疾病中最流行的一些传染源，通过属于该属的蚊子传播。热带地区的患病率最高，居住着约 30 亿人。 DENV 每年感染数百万人，并且由于四种血清型的传播而构成额外的卫生挑战，这使疫苗的开发变得复杂。 ZIKV 在全球范围内引起大规模爆发，已知其感染会导致严重的神经系统疾病，包括新生儿小头畸形。此外，事实证明，不仅蚊子控制计划并不完全有效，而且迄今为止还没有开发出抗病毒药物。包膜蛋白 (E) 是 DENV 和 ZIKV 病毒颗粒表面的主要成分。这种蛋白质在病毒进入细胞过程中发挥着关键作用，是抗病毒药物开发的一个有吸引力的靶点。我们之前的研究已经确定了两种嘧啶类似物（3e 和 3h）作为抑制剂；然而，人们发现它们的活性因其低水溶性而受到阻碍。在这
• US3931165A
  申请人：——

  公开号：US3931165A

  公开（公告）日：1976-01-06
• [EN] THIOREDOXIN MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE THIORÉDOXINE ET LEURS UTILISATIONS
  申请人：UNIV CALIFORNIA

  公开号：WO2018175958A1

  公开（公告）日：2018-09-27

  Described herein, inter alia, are compounds and methods for modulating thioredoxin.
• Structure–activity relationships of novel antibacterial translation inhibitors: 3,5-Diamino-piperidinyl triazines
  作者：Yuefen Zhou、Zhongxiang Sun、Jamie M. Froelich、Thomas Hermann、Daniel Wall

  DOI：10.1016/j.bmcl.2006.07.052

  日期：2006.10

  Structure-activity relationships of the 3,5-diamino-piperidinyl triazine series, a novel class of bacterial translation inhibitors, are described. Optimization was focused on the triazine C-4 position in which aromatic substituents that contained electron-withdrawing groups led to potent inhibitors. The initial lack of antibacterial activity was correlated with poor cellular penetration. Whole cell antibacterial activity was achieved by linking additional aromatic moieties at the triazine C-4 position. (c) 2006 Elsevier Ltd. All rights reserved.