2-(5-氨基戊基)胍 | 18431-52-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-(5-氨基戊基)胍
• 英文名称: 1-amino-5-guanidinopentane
• 英文别名: homoagmatine；(5-amino-pentyl)-guanidine；(5-Amino-pentyl)-guanidin；Homoagmatin；1-(5-Aminopentyl)guanidine；2-(5-aminopentyl)guanidine
• CAS: 18431-52-2
• 化学式: C₆H₁₆N₄
• mdl: MFCD19203982
• 分子量: 144.22
• InChiKey: XJHFHPPZQVRVHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  90.4
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 海关编码：
  2925290090

反应信息

• 作为反应物：
  描述：

  2-(5-氨基戊基)胍 在 palladium on activated charcoal 氢气 、 碳酸氢钠 作用下， 以 甲醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  六氢聚雄果核苷的合成（修订结构）

  摘要：

  先前指定的六氢聚雄果核苷I和II的结构已被修改，六氢聚雄果核苷I [1-（5-胍基戊基）-5-辛基-2-吡咯烷酮]已经合成。

  DOI：

  10.1016/s0040-4039(00)81718-9
• 作为产物：
  描述：

  1,5-二氨基戊烷 、 S-乙基异硫脲氢溴酸盐 在 乙醇 作用下， 生成 2-(5-氨基戊基)胍
  参考文献：
  名称：

  Strack, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1929, vol. 180, p. 201,209

  摘要：

  DOI：

文献信息

• Acyl and carbamimidoyl alkanediamines
  申请人：University of Illinois Foundation

  公开号：US04762949A1

  公开（公告）日：1988-08-09

  Synthetically produced substantially pure biologically active compounds having the general formula ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.20 alkyl, alkenyl, aryl, aralkyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkenyl, alkylcycloalkenyl, or cycloalkenylalkyl; R.sub.2 is hydrogen, C.sub.1 -C.sub.10 alkyl or an amide-substituted alkyl having up to 10 carbon atoms; R.sub.3 is a cyclic, straight or branched chain hydrocarbon group having 2-12 carbon atoms, particularly --(CH.sub.2).sub.n --, wherein n is 2-12; or R.sub.2 and R.sub.3 are linked together to form an alkylene chain; and R.sub.4 is selected from ##STR2## (substituted or unsubstituted carbamimidoyl), ##STR3## (dimethylpyrimidyl), or ##STR4## (carbamyl) wherein each of R.sub.5, R.sub.6, and R.sub.7 is hydrogen or the same or different C.sub.1 -C.sub.8 alkyl group. The compounds are useful as bactericides for a wide variety of bacteria, including S.pyogenes, B.subtilis, K.pneumoniae, M.avium, B.fragilis, C.perfringens and C.albicans.

  合成生产的基本纯度的生物活性化合物，其一般公式为##STR1##其中R.sub.1是C.sub.1-C.sub.20烷基，烯基，芳基，芳基烷基，环烷基，烷基环烷基，环烷基烷基，环烷烯基，烷基环烷烯基或环烷烯基；R.sub.2是氢，C.sub.1-C.sub.10烷基或具有最多10个碳原子的酰胺取代的烷基；R.sub.3是一个具有2-12个碳原子的环状，直链或支链碳氢化合物基团，特别是--(CH.sub.2).sub.n--，其中n为2-12；或者R.sub.2和R.sub.3连接在一起形成一个烷基链；和R.sub.4从##STR2##（取代或未取代的氨基甲酰基），##STR3##（二甲基嘧啶基），或##STR4##（氨基甲酰基）中选择，其中R.sub.5，R.sub.6和R.sub.7中的每一个是氢或相同或不同的C.sub.1-C.sub.8烷基。这些化合物可用作广泛种类细菌的杀菌剂，包括S.pyogenes，B.subtilis，K.pneumoniae，M.avium，B.fragilis，C.perfringens和C.albicans。
• Homoagmatine from Lathyrus sativus seedlings
  作者：Seethala Ramakrishna、P.Radhakantha Adiga

  DOI：10.1016/0031-9422(73)85082-4

  日期：1973.11

  A new guanidino amine has been isolated from Lathyrus sativus seedlings and chararterized as homoagmatine on the basis of various physico-chemical criteria including IR spectrum and comparison with that chemically synthesized. Homoagmatine is accumulated in the embryos axis while its precursor, homoarginine, is lost from the cotyledons. However, there was a progressive increase in homoarginine content

  根据包括红外光谱在内的各种理化标准以及与化学合成物的比较，已从 Lathyrus sativus 幼苗中分离出一种新的胍基胺，并将其表征为同胍胺。高精氨酸在胚胎轴中积累，而其前体高精氨酸从子叶中丢失。然而，在发育过程中胚胎轴的高精氨酸含量逐渐增加。由于整个幼苗的胺含量对应于高精氨酸水平净减少的近 20-25%，因此可以得出结论，高精氨酸通过高精氨酸的分解代谢代表了氨基酸代谢的主要途径。
• Production process for a guanidine derivative containing an amido group and for a salt thereof
  申请人：Ajinomoto Co., Inc.

  公开号：EP1270552A2

  公开（公告）日：2003-01-02

  A guanidine derivative containing an amido group, represented by is produced by reacting a guanidine derivative containing an amino group represented by with a fatty acid halide or a fatty acid ester.

  一种含有酰胺基的胍衍生物，由含有氨基的胍衍生物与脂肪酸卤化物或脂肪酸酯反应制得。
• Inhibitors of RNase P proteins as antibacterial compounds
  申请人：——

  公开号：US20030134904A1

  公开（公告）日：2003-07-17

  The present invention features compounds useful for inhibiting RNase P activity. These compounds can be used as therapeutics for treating or preventing a variety of bacterial infections. The compounds belong to several classes including mono- and bis-guanylhydrazones, guanylhydrazone mimetics, and benzothiazolium compounds. Exemplary compounds are compounds of formula I: Y—(NR′) k —U 1 —(NR″) I - A -(NR 1 ) m -U 2 —(NR 2 ) n - Z I with substituents as described herein.

  本发明涉及一种用于抑制RNase P活性的化合物。这些化合物可用作治疗或预防各种细菌感染的治疗剂。这些化合物属于几个类别，包括单和双鸟氨酸肼，鸟氨酸肼类似物和苯并噻唑化合物。其中一些化合物的示例为公式I的化合物：Y-（NR'）k-U1-（NR"）I-A-（NR1）m-U2-（NR2）n-ZI，其中具有如下所述取代基。
• BIMODAL STAR POLYMER ARCHITECTURES AS FLUORESCENT AND MRI IMAGING REAGENTS
  申请人：Harth Eva M.

  公开号：US20130029369A1

  公开（公告）日：2013-01-31

  Disclosed are star polymers comprising a polymeric body having a core with a site-isolated chromophore and a plurality of polymer chains emanating from the core; and at least one chelating moiety bonded to at least one polymer chain. Also disclosed are bimodal contrast agents derived from star polymers and further comprising at least one metal chelated by the at least one chelating moiety. Also disclosed are methods of making and using same. Also disclosed are imaging methods employing the disclosed star polymers and/or bimodal contrast agents. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本发明公开了星形聚合物，其包括具有核心的聚合物本体，该核心具有位点隔离的色团，并且从核心发出多个聚合物链；以及至少一个螯合基团与至少一个聚合物链键合。本发明还公开了由星形聚合物衍生的双峰对比剂，其进一步包括由至少一个螯合基团螯合的至少一种金属。本发明还公开了制备和使用上述聚合物和/或双峰对比剂的方法。本发明还公开了采用所公开的星形聚合物和/或双峰对比剂的成像方法。本摘要旨在作为特定领域搜索的扫描工具，不限制本发明。