6-氨基-3,9-二氢-9-甲基-2H-嘌呤-2-酮 hbr | 54746-36-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 6-氨基-3,9-二氢-9-甲基-2H-嘌呤-2-酮 hbr
• 中文别名: 6-氨基-3,9-二氢-9-甲基-2H-嘌呤-2-酮hbr
• 英文名称: 9-Methylisoguanin
• 英文别名: 6-amino-9-methyl-1,9-dihydro-purin-2-one；6-amino-9-methyl-1H-purin-2-one
• CAS: 54746-36-0
• 化学式: C₆H₇N₅O
• 分子量: 165.154
• InChiKey: AXXWYBMTTIBGJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  83.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-amino-9-methyl-2-methylthio-9H-purine 在 sodium dithionite 、 乙醇 、 水 、 氯甲酸乙酯 、 氯 作用下， 生成 6-氨基-3,9-二氢-9-甲基-2H-嘌呤-2-酮 hbr
  参考文献：
  名称：

  Andrews et al., Journal of the Chemical Society, 1949, p. 2490,2494

  摘要：

  DOI：

文献信息

• NOVEL KINASE MODULATORS
  申请人：MUTHUPPALANIAPPAN Meyyappan

  公开号：US20110118257A1

  公开（公告）日：2011-05-19

  The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

  本发明提供了PI3K蛋白激酶调节剂，其制备方法，含有它们的药物组合物，以及使用它们进行激酶介导的疾病或紊乱的治疗、预防和/或改善的方法。
• NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES
  申请人：NAGARATHNAM Dhanapalan

  公开号：US20120289496A1

  公开（公告）日：2012-11-15

  The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

  本发明提供了PI3K蛋白激酶调节剂，其制备方法，含有它们的药物组合物，以及使用它们进行治疗、预防和/或改善激酶介导的疾病或紊乱的方法。
• 3'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN
  申请人：INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

  公开号：US20190183917A1

  公开（公告）日：2019-06-20

  Provided herein are the 3′3′ cyclic phosphonate dinucleotides of general formula J, their pharmaceutically acceptable salts, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.

  本文提供了一般式J的3′3′环磷酸二核苷酸及其药学上可接受的盐、包含它们的制药组合物以及与其他药物或制药品的混合物。本文还涉及使用这些化合物治疗或预防可通过STING蛋白调节改变的疾病或病症，例如癌症或病毒性、过敏性和炎症性疾病。此外，这些物质可以用作疫苗佐剂。
• 2-FLUORINATED RIBOSES AND ARABINOSES AND METHODS OF USE AND SYNTHESIS
  申请人：Sauve Anthony A.

  公开号：US20120108535A1

  公开（公告）日：2012-05-03

  Disclosed are halogenated 2-deoxy-lactone, 2′-deoxy-nucleosides, and derivatives thereof, for example, a compound of formula (I). Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one compound or salt of the invention, and a method of treating a disorder is selected from the group consisting of an abnormal cellular proliferation, a viral infection, and an autoimmune disorder.

  本发明涉及卤代的2-去氧内酯，2'-去氧核苷以及它们的衍生物，例如，化合物式（I）的化合物。本发明还涉及一种包含药学上可接受的载体和至少一种本发明化合物或盐的组合物，以及一种治疗异常细胞增殖、病毒感染和自身免疫性疾病等疾病的方法。
• Nucleic Acid Binding Compounds Containing Pyrazolo[3,4-D]Pyrimidine Analogues of Purin-2,6-Diamine and Their Uses
  申请人：Seela Frank

  公开号：US20110021365A1

  公开（公告）日：2011-01-27

  The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds, various uses thereof and methods for the determination of nucleic acids using said compounds in the field of diagnostics.

  本发明涉及核酸结合化合物领域，包括7-取代7-脱氧-8-氮杂-2,6-二氨基嘌呤碱基的化合物，用于制备此类化合物的化合物，其各种用途以及在诊断领域中使用该化合物确定核酸的方法。