Corydine hydrochloride | 5964-79-4

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 阿朴菲
• 英文名称: Corydine hydrochloride
• 英文别名: (6aS)-2,10,11-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol;hydron;chloride
• CAS: 5964-79-4
• 化学式: C₂₀H₂₃NO₄*ClH
• 分子量: 377.868
• InChiKey: GSOYCJSOFNBVDD-ZOWNYOTGSA-N

物化性质

• 熔点：
  228 °C (decomp)

计算性质

• 辛醇/水分配系数(LogP)：
  3.59
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  51.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  乙醇 、 水 、 碘 、 Corydine hydrochloride 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Gadamer, Archiv der Pharmazie, 1911, vol. 249, p. 664

  摘要：

  DOI：
• 作为产物：
  描述：

  (+)-延胡索碱 在 盐酸 作用下， 以 氘代氯仿 、 水 为溶剂， 生成 Corydine hydrochloride
  参考文献：
  名称：

  Aporphine and bisaporphine alkaloids from Aristolochia lagesiana var. intermedia

  摘要：

  Corydines, isocorydines, and analogous aporphine alkaloids were isolated from the leaves of Aristolochia lagesiana var intermedia, together with three bisaporphine salts (lagesianines B-D) Their structures were determined by chemical derivatizations and spectroscopic analyses Lagesianines B and C are the first examples of N-CH(2)-N' and C-2-O-C-1' linked dimeric aporphine alkaloids, respectively, while the monomeric units of lagesianine D. which has a carbon skeleton, are linked through C-7-C-5' via ail ethane-1,2-diol group (C-7-CHOHCHOH-C-5') (C) 2009 Elsevier Ltd. All rights reserved

  DOI：

  10.1016/j.phytochem.2009.11.010

文献信息

• Gadamer, Archiv der Pharmazie, 1911, vol. 249, p. 664
  作者：Gadamer

  DOI：——

  日期：——
• Aporphine and bisaporphine alkaloids from Aristolochia lagesiana var. intermedia
  作者：Marcia L.R. Ferreira、Inara C. de Pascoli、Isabele R. Nascimento、Julio Zukerman-Schpector、Lucia M.X. Lopes

  DOI：10.1016/j.phytochem.2009.11.010

  日期：2010.3

  Corydines, isocorydines, and analogous aporphine alkaloids were isolated from the leaves of Aristolochia lagesiana var intermedia, together with three bisaporphine salts (lagesianines B-D) Their structures were determined by chemical derivatizations and spectroscopic analyses Lagesianines B and C are the first examples of N-CH(2)-N' and C-2-O-C-1' linked dimeric aporphine alkaloids, respectively, while the monomeric units of lagesianine D. which has a carbon skeleton, are linked through C-7-C-5' via ail ethane-1,2-diol group (C-7-CHOHCHOH-C-5') (C) 2009 Elsevier Ltd. All rights reserved