5-phenyl-1,3-oxazolidine | 60980-84-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-phenyl-1,3-oxazolidine
• 英文别名: 5-phenyloxazolidine
• CAS: 60980-84-9
• 化学式: C₉H₁₁NO
• 分子量: 149.192
• InChiKey: HGRPZJNLVMLELR-UHFFFAOYSA-N

物化性质

• 沸点：
  261.3±28.0 °C(Predicted)
• 密度：
  1.065±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-phenyl-1,3-oxazolidine 以 氯仿 为溶剂， 反应 45.0h， 以80%的产率得到1,3,5-tri(2-phenyl-2-hydroxyethyl)-1,3,5-triazine
  参考文献：
  名称：

  2-(1,3,5-Dithiazinan-5-yl)ethanol Heterocycles, Structure and Reactivity

  摘要：

  DOI：

  10.3987/com-04-10151
• 作为产物：
  描述：

  (+/-)-2-(1,3,5-dithiazinan-5-yl)-1-phenylethanol 190.0 ℃ 、66.66 Pa 条件下， 以90%的产率得到5-phenyl-1,3-oxazolidine
  参考文献：
  名称：

  2-(1,3,5-Dithiazinan-5-yl)ethanol Heterocycles, Structure and Reactivity

  摘要：

  DOI：

  10.3987/com-04-10151

文献信息

• Synthesis of new oxazolidine, oxazolidin-2-one and perhydro-1,4-oxazine derivatives of arylethanolamine as potential<i>beta</i>₃-adrenoceptor agonists
  作者：Antonio Monge、Ignacio Aldana、Hugo Cerecetto、Argimiro Rivero

  DOI：10.1002/jhet.5570320504

  日期：1995.9

  The synthesis of new cyclic compounds, arylethanolamine derivatives, with potential beta3-adrenoceptor agonist selectivity, which are associated with thermogenesis and regulation of insulin release, are described. Oxazolidine, oxazolidin-2-one, and perhydro-1,4-oxazine derivatives were obtained. The preliminary evaluation of the pharmacological effects of some of the synthesized compounds showed an

  的新的环状化合物，芳基乙醇胺衍生物，与潜在合成的β 3肾上腺素能受体激动剂的选择性，这是与热作用和胰岛素释放的调节相关，进行了描述。获得恶唑烷，恶唑烷-2-酮和全氢-1,4-恶嗪衍生物。的一些合成的化合物的药理作用的初步评估显示lypolysis的在大鼠脂肪细胞与效力和效率类似于用于其它认可观察到活化的β 3肾上腺素能激动剂。
• Haloacyl and thiohaloacyl aryl-substituted oxazolidines and
  申请人：Stauffer Chemical Company

  公开号：US04400200A1

  公开（公告）日：1983-08-23

  Haloacyl and thiohaloacyl aryl-substituted oxazolidines and thiazolidines useful as active antidotes against crop injury when used with various herbicides; herbicidal compositions and utility of various herbicides and aryl substituted oxazolidines and thiazolidines having the formula ##STR1## wherein X and Y are independently oxygen or sulfur; R is haloalkyl or chloroalkenyl; R.sub.1 is hydrogen, lower alkyl, phenyl, naphthyl, substituted phenyl wherein said substituents are monofluoro, mono- or di- chloro, nitro, methyl, methoxy, or hydroxyl; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen, lower alkyl, hydroxymethyl, N-methyl carbamoyloxymethyl or dichloroacetoxymethyl; R.sub.4 is hydrogen or lower alkyl; R.sub.5 is hydrogen, lower alkyl or phenyl; and R.sub.6 is hydrogen; provided that at least one of R.sub.1 or R.sub.5 is phenyl, substituted phenyl or naphthyl.

  Haloacyl和thiohaloacyl芳基取代的噁唑烷和噻唑烷，与各种除草剂一起使用时，可用作活性解毒剂，防止作物受损伤。此外，还包括除草剂组合物以及具有以下式子的芳基取代的噁唑烷和噻唑烷的用途：##STR1## 其中，X和Y分别是氧或硫；R是卤代烷基或氯代烯基；R.sub.1是氢、低碳基、苯基、萘基、取代苯基，其中所述取代基是单氟、单氯或双氯、硝基、甲基、甲氧基或羟基；R.sub.2是氢或低碳基；R.sub.3是氢、低碳基、羟甲基、N-甲基氨基甲氧甲基或二氯乙酰氧甲基；R.sub.4是氢或低碳基；R.sub.5是氢、低碳基或苯基；R.sub.6是氢；但是，至少R.sub.1或R.sub.5中的一个是苯基、取代苯基或萘基。
• Heterocyclic Derivatives and Their Use as Stearoyl-Coa Desaturase Inhibitors
  申请人：Kamboj Rajender

  公开号：US20080096895A1

  公开（公告）日：2008-04-24

  Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, V R 2 , R 3 , R 4 , R 5 , R 5a , R 6 , R 6a , R 7 , R 7a , R 8 and R 8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

  本文披露了一种治疗哺乳动物（最好是人类）SCD介导的疾病或病症的方法，其中方法包括向需要该方法的哺乳动物施用式（I）的化合物：其中x、y、G、J、K、L、M、V、R2、R3、R4、R5、R5a、R6、R6a、R7、R7a、R8和R8a在本文中有定义。本文还披露了包含式（I）化合物的药物组合物。
• Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
  申请人：Xenon Pharmaceuticals Inc.

  公开号：US07767677B2

  公开（公告）日：2010-08-03

  Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, V R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

  本发明揭示了治疗哺乳动物，尤其是人类SCD介导的疾病或病况的方法，其中该方法包括向需要该药物的哺乳动物内给予化合物(I)的方法，其中化合物(I)的公式如下：其中x、y、G、J、K、L、M、V、R2、R3、R4、R5、R5a、R6、R6a、R7、R7a、R8和R8a在此定义。本发明还揭示了包含化合物(I)的制药组合物。
• [EN] HETEROCYCLIC DERIVATIVES AND THEIR USE AS STEAROYL-COA DESATURASE INHIBITORS<br/>[FR] DERIVES HETEROCYCLIQUES ET LEUR UTILISATION EN TANT QU'AGENTS THERAPEUTIQUES
  申请人：XENON PHARMACEUTICALS INC

  公开号：WO2006034440A3

  公开（公告）日：2006-08-10