(S)-N-(1-hydroxy-3-methylbutan-2-yl)isobutyramide | 1178003-94-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-N-(1-hydroxy-3-methylbutan-2-yl)isobutyramide
• 英文别名: N-(1-hydroxy-3-methylbutan-2-yl)isobutyramide；N-[(2S)-1-hydroxy-3-methylbutan-2-yl]-2-methylpropanamide
• CAS: 1178003-94-5
• 化学式: C₉H₁₉NO₂
• 分子量: 173.255
• InChiKey: DOUWTIQRKVVOAH-MRVPVSSYSA-N

物化性质

• 熔点：
  34-35 °C
• 沸点：
  325.0±25.0 °C(Predicted)
• 密度：
  0.953±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S)-N-(1-hydroxy-3-methylbutan-2-yl)isobutyramide 在 4-二甲氨基吡啶 、 甲基磺酰氯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以60%的产率得到(4S)-2,4-diisopropyl-4,5-dihydrooxazole
  参考文献：
  名称：

  Chiral dinuclear phthalazine bridged bisoxazoline ligands: synthesis and application in enantioselective Cu-catalyzed conjugate addition of ZnEt2 to enones

  摘要：

  A new class of chiral dinuclear ligands with phthalazine bridged bisoxazoline scaffold was designed and prepared in convenient synthetic routes. H-1 NMR analysis showed that this class of ligands could coordinate with two metal ions, either same or different. These ligands afforded good to excellent yields and enantioselectivities in Cu-catalyzed conjugate addition of ZnEt2 to enones. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.098
• 作为产物：
  描述：

  L-缬氨醇 、 异丁酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以86%的产率得到(S)-N-(1-hydroxy-3-methylbutan-2-yl)isobutyramide
  参考文献：
  名称：

  Chiral dinuclear phthalazine bridged bisoxazoline ligands: synthesis and application in enantioselective Cu-catalyzed conjugate addition of ZnEt2 to enones

  摘要：

  A new class of chiral dinuclear ligands with phthalazine bridged bisoxazoline scaffold was designed and prepared in convenient synthetic routes. H-1 NMR analysis showed that this class of ligands could coordinate with two metal ions, either same or different. These ligands afforded good to excellent yields and enantioselectivities in Cu-catalyzed conjugate addition of ZnEt2 to enones. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.098

文献信息

• US7304071B2
  申请人：——

  公开号：US7304071B2

  公开（公告）日：2007-12-04
• US7326706B2
  申请人：——

  公开号：US7326706B2

  公开（公告）日：2008-02-05
• US7507820B2
  申请人：——

  公开号：US7507820B2

  公开（公告）日：2009-03-24
• Chiral dinuclear phthalazine bridged bisoxazoline ligands: synthesis and application in enantioselective Cu-catalyzed conjugate addition of ZnEt2 to enones
  作者：Liang Zhang、Guoqiang Yang、Chaoren Shen、Sabah Arghib、Wanbin Zhang

  DOI：10.1016/j.tetlet.2011.02.098

  日期：2011.5

  A new class of chiral dinuclear ligands with phthalazine bridged bisoxazoline scaffold was designed and prepared in convenient synthetic routes. H-1 NMR analysis showed that this class of ligands could coordinate with two metal ions, either same or different. These ligands afforded good to excellent yields and enantioselectivities in Cu-catalyzed conjugate addition of ZnEt2 to enones. (C) 2011 Elsevier Ltd. All rights reserved.
• Thermo-, and pH dual-responsive poly(N-vinylimidazole): Preparation, characterization and its switchable catalytic activity
  作者：Bin Wang、Hua-Ji Liu、Ting-Ting Jiang、Qi-Heng Li、Yu Chen

  DOI：10.1016/j.polymer.2014.09.051

  日期：2014.11

  A monomer, 2-(isobutyramido)-3-methylbutyl methacrylate (IMMA) was synthesized through a two-step reaction. When a few of IMMA (less than 4 mol%) was copolymerized with N-vinylimidazole (Vim) under free radical polymerization condition, water-soluble P(VIm-co-IMMA) copolymers were obtained. Their structural information was verified and interpreted from H-1 NMR, FTIR and GPC. Kinetic analyses from H-1 NMR demonstrated that one-batch addition of IMMA into the polymerization system led to an inhomogeneous distribution of IMMA units in the copolymers, whereas homogeneous distribution of IMMA units in the copolymers could be obtained through the portion-wise addition of IMMA monomer. The thermal properties of such copolymers were measured by DSC. Compared with PVIm homopolymer, the few IMMA units in the P(VIm-co-IMMA) copolymer had little influence on the T-g values. The obtained P(VIm-co-IMMA) copolymers were thermoresponsive in water, and their phase transition temperatures could be efficiently raised through reducing the IMMA content in the copolymers, raising the addition times of IMMA monomers or lowering the pH of media. Dynamic light scattering analysis showed that unlike the traditional thermoresponsive linear polymers, obvious size shrinkage around the phase transition temperature could not be observed in such P(VIm-co-IMMA) copolymers. Such copolymers could be used as smart organocatalysts in the hydrolysis of p-nitrophenyl acetate. Below the phase transition temperature the reaction rate followed the Arrhenius law, but above the phase transition temperature the reaction rate increased much slower than the prediction from the Arrhenius law. Moreover, the catalytic transition temperature could be tuned through utilizing the P(VIm-co-IMMA) copolymers with different phase transition temperature. The mechanism was discussed accordingly. (C) 2014 Elsevier Ltd. All rights reserved.