2,3-bis-acetylamino-anthraquinone | 56250-74-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 2,3-bis-acetylamino-anthraquinone
• 英文别名: 2,3-Bis-acetylamino-anthrachinon；2.3-Bis-acetamino-anthrachinon；N.N'-Diacetyl-2.3-diamino-anthrachinon；N,N'-diacetyl-2,3-diaminoanthraquinone；N-(3-acetamido-9,10-dioxoanthracen-2-yl)acetamide
• CAS: 56250-74-9
• 化学式: C₁₈H₁₄N₂O₄
• 分子量: 322.32
• InChiKey: WZVQIFXIIDLLMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  92.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-amino-3-nitroanthraquinone 在 sodium sulfide 、 水 作用下， 生成 2,3-bis-acetylamino-anthraquinone
  参考文献：
  名称：

  Permeability of the Blood-Brain Barrier to Albumin and Insulin in the Young and Aged SAMP8 Mouse

  摘要：

  The decrease in the insulin cerebrospinal fluid/serum ratio seen in Alzheimer's disease has been suggested as a mechanism by which brain glucose utilization could be perturbed. Insulin is transported across the blood-brain barrier (BBB) by a system that is altered by pathophysiological events. We used SAMP8 mice, a strain that by 8-12 months of age develops severe deficits in learning and memory, to determine whether the insulin transporter or BBB integrity was altered with aging. BBB integrity was measured by injecting radioactive albumin intravenously, washing out the vascular space up to 17 hours later, and measuring brain/serum ratios. This very sensitive method found no increase in the permeability of the BBB to albumin in young and aged SAMP8 mice. This compares with previous studies in humans with Alzheimer's disease and in other colonies of SAMP8 mice that have found evidence for BBB disruption. For radioactively labeled insulin, we used multiple-time regression analysis to measure both the unidirectional influx rate (Ki) and the reversible binding to brain endothelium (Vi). A nonsignificant decrease in the transport rate for whole brain occurred in aged SAMP8 mice. Ki and Vi values significantly varied among brain regions and the Ki for the thalamus and the Vi for the cerebellum and thalamus were higher in aged mice. We conclude that alterations in BBB integrity or the activity of the BBB insulin transporter do not underlie the deficits in learning and memory seen in the aged SAMP8 mouse.

  DOI：

  10.1093/gerona/55.12.b601

文献信息

• LOSKUTOV V. A.; KRUGLYAK T. I.; KONSTANTINOVA A. V.; FOKIN E. P., IZV. SIB. OTD. AN CCCP <IZSK-AV>, 1975, HO 4, CEP. XIM. N. VYP. 2, 128-13+
  作者：LOSKUTOV V. A.、 KRUGLYAK T. I.、 KONSTANTINOVA A. V.、 FOKIN E. P.

  DOI：——

  日期：——